(S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮
- 中文名称：
- (S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮
- 中文别名：
-
- 英文名称：
- (7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
- 英文别名：
- (7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one;
N,N-dimethyldeacetylcolchicine;
N-Methyldemecolcine;
N-Deacetyl-N,N-dimethylcolchicine;
Demecolcine,N-methyl;
N,N-Dimethyl-desacetyl-colchicin;
N-Methyl-demecolcin;
Methylademecolcine,N;
N-methyldemocolcine;
COLCHICINE,N-DEACETYL-N,N-DIMETHYL;
N-Methylcolchamine
- CAS No.：
- 7336-44-9
- 分 子 式：
-
C22H27NO5
- 分 子 量：
- 385.45300
- 精确分子量：
- 385.18900
- PSA：
- 57.23000
- InChI：
- The Key: NDKXARFZWSQXGE-INIZCTEOSA-N3
- 分子结构式：
-
- SDS：
- 查看
(S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮 物化性质
- 密度：
- 1.2g/cm3
- 沸点：
- 619.7ºC at 760 mmHg
- 闪点：
- 328.6ºC
- 折射率：
- 1.581
(S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0792000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 7336-44-9
- LAST UPDATED :
- 198706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C22-H27-N-O5
- MOLECULAR WEIGHT :
- 385.50
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981
(S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮 上游产品
