匹卡米隆
- 中文名称：
- 匹卡米隆
- 中文别名：
- 甲硫二苯马尼;
N,N-二甲基-4-哌啶亚基-1,1-二苯甲烷甲基硫酸盐;
吡拉西坦
- 英文名称：
- Pikamilone
- 英文别名：
- diphemanil methylsulfate;
Talpran;
Diphenmethanil;
Nivelona;
Demotil;
DIPHEMANIL METHYLSULFATE;
Diphemanil Methylsulfate;
Variton;
Diphemanil metilsulfate;
Diphenmanil (methylsulfate);
Diphemanil;
4-benzhydrylidene-1,1-dimethyl-piperidinium,methyl sulfate;
4-Benzhydryliden-1,1-dimethyl-piperidinium,Methylsulfat;
4-benzhydrylidene-1,1-dimethylpiperidin-1-ium,methyl sulfate;
Prantal;
Nivelon
- CAS No.：
- 62-97-5
- 分 子 式：
-
C10H12N2O3
- 分 子 量：
- 389.50800
- 精确分子量：
- 389.16600
- PSA：
- 74.81000
- EINECS：
- 200-552-4
- InChI：
- InChI=1/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;1-5-6(2,3)4/h3-12H,13-16H2,1-2H3;1H3,(H,2,3,4)/q+1;3
- SDS：
- 查看
匹卡米隆 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN5075000
- CHEMICAL NAME :
- Piperidinium, 4-(diphenylmethylene)-1,1-dimethyl-,
methyl sulfate
- CAS REGISTRY NUMBER :
- 62-97-5
- LAST UPDATED :
- 199203
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C20-H24-N.C-H3-O4-S
- MOLECULAR WEIGHT :
- 389.55
- WISWESSER LINE NOTATION :
- T6K DYTJ A1 A1 DUYR&R &WSO&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1107 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,576,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
spasmolytic)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 23,461,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 317 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,576,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,576,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4012 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 103,100,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,576,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 404 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 78,576,1951
匹卡米隆 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:4
4.可旋转化学键数量:2
5.互变异构体数量:无
6.拓扑分子极性表面积:74.8
7.重原子数量:27
8.表面电荷:0
9.复杂度:426
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:2
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甲硫二苯马尼
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- Cas号：62-97-5
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