1,2,4-三氯苯,120-82-1，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

上游产品

下游产品

表征图谱

1,2,4-三氯苯

中文名称：: 1,2,4-三氯苯

中文别名：: 三氯苯;
1,2,4-三氯苯

英文名称：: 1,2,4-Trichlorobenzene

英文别名：: 1,2,4-trichlorobenzene;
1,2,4-Trichlorobenzol;
Hipochem GM;
Hostetex l-pec;
Trojchlorobenzen;
as-trichlorobenzene;
1,2,5-Trichlorobenzene;
1,2,4-Trichlorobenzene;
1,2,4-trichloro-benzene;
1,4,5-trichlorobenzene;
1,2,4-Trichlorobenze;
1,3,4-trichlorobenzene;
1,2,4-Trichlorbenzene;
1,2,4-Trichlorbenzol

CAS No.：: 120-82-1

分子式：: C₆H₃Cl₃

分子量：: 181.45

精确分子量：: 179.93000

PSA：: 0.00000

MDL：: MFCD00000547

EINECS：: 204-428-0

BRN：: 956819

InChI：: The Key: PBKONEOXTCPAFI-UHFFFAOYSA-N3

危险品标志：: Xn;N

风险术语：: R22;R38;R50/53

安全术语：: S23;S37/39;S60

分子结构式：

SDS：: 查看

1,2,4-三氯苯制备方法及用途

制备方法

1.热解法干燥的六六六无毒体在热解釜中加热热即得三氯苯,同时副产大量氯化氢。 2.碱解法六六六无毒体与石灰乳共热即得三氯苯,同时副产大量氯化钙液。上述二法所得三氯苯均为1,2,4-三氯苯;1,3,5-三氯苯;1,2,3-三氯苯三种异构体的混合物,以1,2,4-三氯苯为主要组分。石灰乳法生产的三氯苯中,1,2,4-三氯苯含量在75%以上,1,2,3-三氯苯约占20%。

合成制备方法

1.热解法干燥的六六六无毒体在热解釜中加热热即得三氯苯，同时副产大量氯化氢。

2.碱解法六六六无毒体与石灰乳共热即得三氯苯，同时副产大量氯化钙液。

上述二法所得三氯苯均为1,2,4-三氯苯；1,3,5-三氯苯；1,2,3-三氯苯三种异构体的混合物，以1,2,4-三氯苯为主要组分。石灰乳法生产的三氯苯中，1,2,4-三氯苯含量在75%以上，1,2,3-三氯苯约占20%。

用途简介

1.医药;染料;农药的原料,也是用途很广的高沸点溶剂,变压器内电阻液的原料。用作高熔点物质重结晶用溶剂、电器设备冷却剂、润滑油添加剂、脱脂剂、油溶性染料溶剂、白蚁驱除剂等,也用作制造2,5-二氯苯酚的原料。工业品为各种异构体(1,2,3-,1,2,4-,1,2,5-三氯苯)的混合物。 2.用作溶剂及染料、绝缘液、杀虫剂的合成,也作热载体,及用于有机合成。

用途

1.医药；染料；农药的原料，也是用途很广的高沸点溶剂，变压器内电阻液的原料。用作高熔点物质重结晶用溶剂、电器设备冷却剂、润滑油添加剂、脱脂剂、油溶性染料溶剂、白蚁驱除剂等，也用作制造2,5-二氯苯酚的原料。工业品为各种异构体（1,2,3-，1,2,4-，1,2,5-三氯苯）的混合物。

2.用作溶剂及染料、绝缘液、杀虫剂的合成，也作热载体，及用于有机合成。^[28]

1,2,4-三氯苯毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC2100000

CHEMICAL NAME :: Benzene, 1,2,4-trichloro-

CAS REGISTRY NUMBER :: 120-82-1

BEILSTEIN REFERENCE NO. :: 0956819

LAST UPDATED :: 199712

DATA ITEMS CITED :: 31

MOLECULAR FORMULA :: C6-H3-Cl3

MOLECULAR WEIGHT :: 181.44

WISWESSER LINE NOTATION :: GR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 756 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6139 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg/14D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7380 mg/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1800 mg/kg

SEX/DURATION :: female 9-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 2,111,1987 *** REVIEWS *** ACGIH TLV-CL 37 mg/m3 (5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-BELGIUM:STEL 5 ppm (37 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 5 ppm (40 mg/m3);STEL 10 ppm (74 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (40 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (40 mg/m3);STEL 5 ppm (40 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,2,4-TRICHLOROBENZENE-air:CL 5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83334 No. of Facilities: 74 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 1687 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83334 No. of Facilities: 78 (estimated) No. of Industries: 6 No. of Occupations: 14 No. of Employees: 4033 (estimated) No. of Female Employees: 1463 (estimated)

毒理学数据：

1、急性毒性：

大鼠经口LD50：756mg/kg；大鼠经皮下LD50：6139mg/kg；小鼠经口LD50：300mg/kg；小鼠腹膜腔LD50：1223mg/kg；

2、其它多剂量毒性：大鼠经口TDLO：280mg/kg/14D-C；大鼠经口TDLO：7380mg/kg/13W-C；

3、生殖数据：大鼠经口TDLO：1800mg/kg/25W-I；大鼠（雌）腹膜腔TDLO：750mg/kg/3D；

4、致突变毒性：小鼠微核试验：210mg/kg/24H；5、毒性和二氯苯相同，对上呼吸道及黏膜刺激。嗅觉阈浓度0.01mg/L（水质）。

5.急性毒性^[15]

LD50：756mg/kg（大鼠经口）；6139mg/kg（大鼠经皮）；6100mg/kg（兔经皮）

6.刺激性^[16] 家兔经皮：1950mg（13周，间断），中度刺激。

7.致突变性^[17] 微核试验：小鼠腹腔内给予最低中毒剂量（TDLo）210mg/kg（24h）

生态数据：

1.生态毒性^[18] LC50：1.95mg/L（48h）（虹鳟鱼）；109mg/L（24h），13mg/L（48h），3.36mg/L（96h）（蓝鳃太阳鱼）；2.92mg/L（96h）（黑头呆鱼）

2.生物降解性^[19]

好氧生物降解（h）：672~4320

厌氧生物降解（h）：2688~17280

3.非生物降解性^[20]

光解最大光吸收波长范围（nm）：278~286

空气中光氧化半衰期（h）：128.4~1284

一级水解半衰期（h）：29784

4.生物富集性^[21] BCF：420~1140（鲤鱼，接触浓度50μg/L，接触时间6周）；120~1300（鲤鱼，接触浓度5μg/L，接触时间6周）

1,2,4-三氯苯

1,2,4-三氯苯制备方法及用途

制备方法

合成制备方法

用途简介

用途

1,2,4-三氯苯物化性质

1,2,4-三氯苯安全信息

1,2,4-三氯苯毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2,4-三氯苯 MSDS

1,2,4-三氯苯分子结构与计算化学数据

分子结构数据

计算化学数据

1,2,4-三氯苯上游产品

1,2,4-三氯苯下游产品

1,2,4-三氯苯表征图谱

推荐供应商

1,2,4-三氯苯

1,2,4-三氯苯 制备方法及用途

制备方法

合成制备方法

用途简介

用途

1,2,4-三氯苯 物化性质

1,2,4-三氯苯 安全信息

1,2,4-三氯苯 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2,4-三氯苯 MSDS

1,2,4-三氯苯 分子结构与计算化学数据

分子结构数据

计算化学数据

1,2,4-三氯苯 上游产品

1,2,4-三氯苯 下游产品

1,2,4-三氯苯 表征图谱

推荐供应商

1,2,4-三氯苯制备方法及用途

1,2,4-三氯苯物化性质

1,2,4-三氯苯安全信息

1,2,4-三氯苯毒理性

1,2,4-三氯苯分子结构与计算化学数据

1,2,4-三氯苯上游产品

1,2,4-三氯苯下游产品

1,2,4-三氯苯表征图谱