2-氯-3-甲基吡啶
- 中文名称：
- 2-氯-3-甲基吡啶
- 中文别名：
- 三亚胺醌
- 英文名称：
- 2,5-Cyclohexadiene-1,4-dione,2,3,5-tri-1-aziridinyl-
- 英文别名：
- triaziquone;
Trenimon;
Triethyleneiminobenzoquinone;
Riker 601;
Oncoredox;
2,3,5-tris(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione;
Triaziquinone;
Prenimon;
Treninon;
2.3.5-Tris-aziridino-benzo-1.4-chinon;
Oncovedex;
Triaziquon
- CAS No.：
- 68-76-8
- 分 子 式：
-
C12H13N3O2
- 分 子 量：
- 231.25052
- 精确分子量：
- 231.10100
- PSA：
- 43.17000
- EINECS：
- 200-692-6
- InChI：
- The Key: PXSOHRWMIRDKMP-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
2-氯-3-甲基吡啶 物化性质
- 密度：
- 1.727g/cm3
- 熔点：
- 162.5-163ºC
- 沸点：
- 376.5ºC at 760 mmHg
- 闪点：
- 175.1ºC
- 折射率：
- 1.846
2-氯-3-甲基吡啶 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK7175000
- CHEMICAL NAME :
- p-Benzoquinone, 2,3,5-tris(1-aziridinyl)-
- CAS REGISTRY NUMBER :
- 68-76-8
- BEILSTEIN REFERENCE NO. :
- 0238057
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 98
- MOLECULAR FORMULA :
- C12-H13-N3-O2
- MOLECULAR WEIGHT :
- 231.28
- WISWESSER LINE NOTATION :
- L6V DVJ B- AT3NTJ& C- AT3NTJ& E- AT3NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Blood - leukopenia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1560 ug/kg/1Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - oogenesis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - germ cell effects (in offspring)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 20 ug/kg
- SEX/DURATION :
- female 15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Heritable translocation test
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- DNA inhibition
- TYPE OF TEST :
- DNA inhibition
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Dominant lethal test
- TYPE OF TEST :
- Sperm Morphology
- TYPE OF TEST :
- Heritable translocation test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 14 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 65,21,1979
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,67,1975
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,67,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,367,1987
TOXICOLOGY REVIEW
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
28,135,1971
2-氯-3-甲基吡啶 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:5
4.可旋转化学键数量:3
5.互变异构体数量:无
6.拓扑分子极性表面积:43.2
7.重原子数量:17
8.表面电荷:0
9.复杂度:494
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
推荐供应商
湖北恩星生物科技有限公司
三亚胺醌
- 联系人：邵经理
- 电 话：16621771607
- 手 机：16621771607
- Cas号：68-76-8
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：
- 价格：64.0元 - 100.0元
湖北实兴化工有限公司
三亚胺醌
- 联系人：张妍
- 电 话：13554155445
- 手 机：13554155445
- Cas号：68-76-8
- 包装：1kg,25kg,50kg,200kg,500kg
- 纯度：99%
- 价格：1.0元 - 10.0元
郑州杰克斯化工有限公司
三亚胺醌
- 联系人：许伟伟
- 电 话：0371-86259281 15981966935
- 手 机：15981966935
- Cas号：68-76-8
- 包装：洽谈
- 纯度：
- 价格：洽谈
