二溴甘露醇
- 中文名称：
- 二溴甘露醇
- 中文别名：
- 二溴甘露醇;
二溴脱氧己六醇
- 英文名称：
- Galactitol,1,6-dibromo-1,6-dideoxy-
- 英文别名：
- (2R,3S,4R,5S)-1,6-dibromohexane-2,3,4,5-tetrol;
1,6-Dibromodulcitol;
1,6-Dibrom-1,6-didesoxy-galactit;
Mitolactol;
Dibromdulcitol;
Dibromdulcit;
1,6-Dibrom-galacto-hexan-2,3,4,5-tetraol;
1,6-Dibromodideoxydulcitol;
1,6-dibromo-1,6-dideoxygalactitol;
dibromodulcitol;
Elobromol
- CAS No.：
- 10318-26-0
- 分 子 式：
-
C6H12Br2O4
- 分 子 量：
- 307.96
- 精确分子量：
- 305.91000
- PSA：
- 80.92000
- InChI：
- The Key: VFKZTMPDYBFSTM-GUCUJZIJSA-N3
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
二溴甘露醇 制备方法及用途
制备方法
由D-甘露醇与氢溴酸反应得到二溴甘露醇。将甘露溶解于氢溴酸,加热回流3h。加水稀释并降温至52℃,加入活性炭脱色。过滤,将滤液降温至20℃,搅拌下用碳酸氢钠调节pH至1-2,冷冻后甩滤、水洗、氯仿洗,真空干燥后用甲醇重结晶、活性炭脱色精制而得成品。收率约36%。
用途简介
本品为抗肿瘤药物。大鼠口服LD50为1400mg/kg。
二溴甘露醇 物化性质
- 密度：
- 2.117g/cm3
- 熔点：
- 183-185ºC
- 沸点：
- 511.2ºC at 760mmHg
- 闪点：
- 263ºC
- 折射率：
- 1.622
- 蒸汽压：
- 1.37E-12mmHg at 25°C
二溴甘露醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LW5425000
- CHEMICAL NAME :
- Galactitol, 1,6-dibromo-1,6-dideoxy-
- CAS REGISTRY NUMBER :
- 10318-26-0
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C6-H12-Br2-O4
- MOLECULAR WEIGHT :
- 308.00
- WISWESSER LINE NOTATION :
- E1YQYQYQYQ1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 72 mg/kg/D
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5850 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- DNA adduct
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rabbit Bone marrow
- DOSE/DURATION :
- 390 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
25,1705,1976
二溴甘露醇 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:4
3.氢键受体数量:4
4.可旋转化学键数量:5
5.互变异构体数量:无
6.拓扑分子极性表面积:80.9
7.重原子数量:12
8.表面电荷:0
9.复杂度:110
10.同位素原子数量:0
11.确定原子立构中心数量:4
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
推荐供应商
湖北恩星生物科技有限公司
二溴甘露醇
- 联系人：邵经理
- 电 话：16621771607
- 手 机：16621771607
- Cas号：10318-26-0
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：
- 价格：64.0元 - 100.0元
