盐酸氯普鲁卡因,3858-89-7，生产厂家，价格-洛克化工网移动版

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基本信息

物化性质

毒理性

结构与计算化学

上游产品

盐酸氯普鲁卡因

中文名称：: 盐酸氯普鲁卡因

中文别名：: 盐酸氯普鲁卡因;
4-氨基-2-氯苯甲酸 2-(二乙氨基)乙酯盐酸盐;
纳塞卡因

英文名称：: Benzoic acid,4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)

英文别名：: chloroprocaine hydrochloride;
Chloroprocaine Hcl;
UNII-LT7Z1YW11H;
2-diethylaminoethyl 4-amino-2-chlorobenzoate hydrochloride;
Chloroprocaine HCl;
Chlorprocainchlorid;
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate,hydrochloride;
Chloroprocaine hydrochloride

CAS No.：: 3858-89-7

分子式：: C₁₃H₁₉ClN₂O₂.ClH

分子量：: 307.22

精确分子量：: 306.09000

PSA：: 41.57000

EINECS：: 223-371-2

InChI：: InChI=1/C13H19ClN2O2.ClH/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14;/h5-6,9H,3-4,7-8,15H2,1-2H3;1H3

危险品标志：

风险术语：

安全术语：

分子结构式：

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盐酸氯普鲁卡因毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575200

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 3858-89-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H19-Cl-N2-O2.Cl-H

MOLECULAR WEIGHT :: 307.25

WISWESSER LINE NOTATION :: ZR CG DVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraspinal

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 9677 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,677,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 266 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,501,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 75,215,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5336 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)