对氯苯丁胺
- 中文名称：
- 对氯苯丁胺
- 中文别名：
- 对氯苯丁胺;
1-(4-氯苯基)-2-甲基-2-丙胺
- 英文名称：
- chlorophentermine
- 英文别名：
- 1-(4-chlorophenyl)-2-methylpropan-2-amine;
Lucofen SA;
Chlorphenterminum [INN-Latin];
Effox;
Chlorphenterminum;
Clorfentermina [INN-Spanish];
3-(4-chlorophenyl)-2-methyl-2-propylamin;
Clorfentermina;
Teramine;
chlorophentermine;
chlorphentermine;
Desopimon;
1,1-dimethyl-2-(4-chlorophenyl)ethylamine
- CAS No.：
- 461-78-9
- 分 子 式：
-
C10H14ClN
- 分 子 量：
- 0
- 精确分子量：
- 183.08100
- PSA：
- 26.02000
- EINECS：
- 207-314-9
- InChI：
- The Key: ZCKAMNXUHHNZLN-UHFFFAOYSA-N3
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
对氯苯丁胺 物化性质
- 密度：
- 1.074g/cm3
- 沸点：
- 255.8ºC at 760mmHg
- 闪点：
- 127ºC
- 折射率：
- 1.537
- 蒸汽压：
- 0.016mmHg at 25°C
对氯苯丁胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SH1050000
- CHEMICAL NAME :
- Phenethylamine, p-chloro-alpha,alpha-dimethyl-
- CAS REGISTRY NUMBER :
- 461-78-9
- BEILSTEIN REFERENCE NO. :
- 1099928
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C10-H14-Cl-N
- MOLECULAR WEIGHT :
- 183.70
- WISWESSER LINE NOTATION :
- ZX1&1&1R DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 5357 ug/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - sympathomimetic
Vascular - BP elevation not characterized in autonomic section
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 720 mg/kg/6W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg/15W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg/6W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3900 mg/kg/13W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 480 mg/kg
- SEX/DURATION :
- female 10-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
- TYPE OF TEST :
- Unscheduled DNA synthesis
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg/5D (Continuous)
- REFERENCE :
- 40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology
as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan,
eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year:
-,459,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,89,1976
推荐供应商
江苏海翔化工有限公司
对氯苯丁胺
- 联系人：周逸
- 电 话：+86-519-82331677;82311677;80191677
- 手 机：13915811283
- Cas号：461-78-9
- 包装：2kg
- 纯度：98%-99%
- 价格：洽谈
郑州杰克斯化工有限公司
对氯苯丁胺
- 联系人：许伟伟
- 电 话：0371-86259281 15981966935
- 手 机：15981966935
- Cas号：461-78-9
- 包装：洽谈
- 纯度：
- 价格：洽谈
