阔叶千里光碱
- 中文名称：
- 阔叶千里光碱
- 中文别名：
- 阔叶千里光碱;
闊葉千里光鹼
- 英文名称：
- platyphylline
- 英文别名：
- 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;
480-78-4
- CAS No.：
- 480-78-4
- 分 子 式：
-
C18H27NO5
- 分 子 量：
- 337.41
- 精确分子量：
- 337.18900
- PSA：
- 76.07000
- EINECS：
- 207-558-6
- InChI：
- The Key: BTHCJHQOYFUIMG-REYNEDSXSA-N3
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
阔叶千里光碱 物化性质
- 密度：
- 1.22 g/cm3
- 沸点：
- 539.6ºC at 760 mmHg
- 闪点：
- 280.1ºC
- 折射率：
- 1.553
阔叶千里光碱 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP2518000
- CHEMICAL NAME :
- Platyphylline
- CAS REGISTRY NUMBER :
- 480-78-4
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H27-N-O5
- MOLECULAR WEIGHT :
- 337.46
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3100 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),34,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 252 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AJEBAK Australian Journal of Experimental Biology and Medical Science.
(Adelaide, S.A., Australia) V.1-64, 1924-86. Volume(issue)/page/year:
46,493,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - hepatitis (hepatocellular necrosis), diffuse
Blood - lymphoma, including Hodgkin's disease
- REFERENCE :
- RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued.
Volume(issue)/page/year: 5,53,1949
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2573 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),34,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 577 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),34,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - hepatitis (hepatocellular necrosis), diffuse
Blood - lymphoma, including Hodgkin's disease
- REFERENCE :
- RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued.
Volume(issue)/page/year: 5,53,1949
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5700 mg/kg/19D-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired
Related to Chronic Data - death
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (1),34,1997
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