硫酸可待因
- 中文名称：
- 硫酸可待因
- 中文别名：
- 硫酸可待因
- 英文名称：
- 3-METHYLMORPHINESULFATESALT
- 英文别名：
- (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol,sulfuric acid;
UNII-AVW5HY4N2E;
Codeine sulfate anhydrous;
EINECS 215-818-5;
codeine sulfate;
Codeine sulphate
- CAS No.：
- 1420-53-7
- 分 子 式：
-
C18H23NO7S
- 分 子 量：
- 397.44
- 精确分子量：
- 397.12000
- PSA：
- 124.91000
- InChI：
- The Key: REJWPZYIFAQSIK-FFHNEAJVSA-N3
- 风险术语：
- 22
- 分子结构式：
-
- SDS：
- 查看
硫酸可待因 物化性质
- 沸点：
- 462ºC at 760mmHg
- 闪点：
- 233.2ºC
- 蒸汽压：
- 2.47E-09mmHg at 25°C
硫酸可待因 安全信息
- 危险类别码：
- 22
- 危险标志：
- Xn: Harmful;
硫酸可待因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD1400000
- CAS REGISTRY NUMBER :
- 1420-53-7
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C36-H42-N2-O6.O4-S
- MOLECULAR WEIGHT :
- 694.86
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JO1 P &
2WSQQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 332 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 395 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 143 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 183 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 68 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - sex ratio
MUTATION DATA
- TEST SYSTEM :
- Fish - not otherwise specified
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16,
1971/72-80. Suspended. Volume(issue)/page/year: 16,425,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 81365
No. of Facilities: 33 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 429 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 81365
No. of Facilities: 86 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 5578 (estimated)
No. of Female Employees: 4863 (estimated)
