格列丁唑
- 中文名称：
- 格列丁唑
- 中文别名：
- 格列丁唑;
N-(5-叔丁基-1,3,4-噻二唑-2-基)苯磺酰胺
- 英文名称：
- Glybuzole
- 英文别名：
- N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;
Gludiase;
Glybuzolum [INN-Latin];
glybuzole;
EINECS 216-081-2;
Desaglybuzol;
Glybuzole [INN:JAN];
AN 1324;
sulfamidothiodiazol;
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl) benzenesulfonamide;
RP 7891;
Glibuzol [INN-Spanish];
Desaglybuzole;
2-Benzolsulfonamino-5-tert.-butyl-1,3,4-thiadiazol
- CAS No.：
- 1492-02-0
- 分 子 式：
-
C12H15N3O2S2
- 分 子 量：
- 297.40
- 精确分子量：
- 297.06100
- PSA：
- 108.57000
- EINECS：
- 216-081-2
- InChI：
- The Key: NMWQEPCLNXHPDX-UHFFFAOYSA-N3
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
格列丁唑 物化性质
- 密度：
- 1.344g/cm3
- 沸点：
- 449.4ºC at 760mmHg
- 闪点：
- 225.6ºC
- 折射率：
- 1.605
- 蒸汽压：
- 2.88E-08mmHg at 25°C
格列丁唑 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DB1290000
- CHEMICAL NAME :
- Benzenesulfonamide,
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)-
- CAS REGISTRY NUMBER :
- 1492-02-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C12-H15-N3-O2-S2
- MOLECULAR WEIGHT :
- 297.42
- WISWESSER LINE NOTATION :
- T5NN DSJ CX1&1&1 EMSWR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 219 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
Endocrine - hypoglycemia
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,131,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 235 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 248 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 193 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 967 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 118 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2100 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2100 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1050 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- YIKUAO Yamaguchi Igaku. Yamaguchi Medicine. (Yamaguchi Daigaku Igakkai,
Kogushi Ube, Yamaguchi- Ken, Japan) V.1- 1953- Volume(issue)/page/year:
18,21,1969
