苯甲孕酮
- 中文名称：
- 苯甲孕酮
- 中文别名：
- 苯甲孕酮;
阿尔孕酮乙酰苯环缩酮;
16alpha,17alpha-二羟基孕甾-4-烯-3,20-二酮-16,17-苯乙酮缩酮;
16α,17α-二羟基-孕甾-4-烯-3,20-二酮-16,17-苯乙酮缩酮
- 英文名称：
- Algestone acetophenide
- 英文别名：
- algestone acetophenide;
Algestone acetophonide;
Algestone acetophenide;
Neolutin Depositum;
alphasoneacetophenide;
deladroxone;
p-dhp;
DIHYDROXYPROGESTERONE ACETOPHENIDE;
droxone;
bovitrol
- CAS No.：
- 24356-94-3
- 分 子 式：
-
C29H36O4
- 分 子 量：
- 448.60
- 精确分子量：
- 448.26100
- PSA：
- 52.60000
- EINECS：
- 246-195-8
- InChI：
- InChI=1/C29H36O4/c1-18(30)29-25(32-28(4,33-29)19-8-6-5-7-9-19)17-24-22-11-10-20-16-21(31)12-14-26(20,2)23(22)13-15-27(24,29)3/h5-9,16,22-25H,10-15,17H2,1-4H3/t22-,23+,24+,25-,26+,27+,28-,29-/m1/s13
- 危险品标志：
-
Xi
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
苯甲孕酮 物化性质
- 密度：
- 1.19g/cm3
- 熔点：
- 150 - 151ºC
- 沸点：
- 579ºC at 760mmHg
- 闪点：
- 246.7ºC
- 折射率：
- 1.59
- 蒸汽压：
- 2.11E-13mmHg at 25°C
苯甲孕酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU5011700
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-,
cyclic acetal with acetophenone, (R)-
- CAS REGISTRY NUMBER :
- 24356-94-3
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C29-H36-O4
- MOLECULAR WEIGHT :
- 448.65
- WISWESSER LINE NOTATION :
- T F5 E5 B666 GO IO RV PUTJ A1 E1 FV1 H1 HR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 750 mg/kg
- SEX/DURATION :
- female 10 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- DOSE :
- 240 mg/kg
- SEX/DURATION :
- male 30 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
V.1- 1963- Volume(issue)/page/year: 10,687,1967
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 mg/kg
- SEX/DURATION :
- female 14-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
71,448,1962
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2250 ug/kg
- SEX/DURATION :
- female 15 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 20 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 79200 ug/kg
- SEX/DURATION :
- male 48 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
V.1- 1963- Volume(issue)/page/year: 8,33,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 396 mg/kg
- SEX/DURATION :
- male 48 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- REFERENCE :
- STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609)
V.1- 1963- Volume(issue)/page/year: 8,33,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 700 mg/kg
- SEX/DURATION :
- female 35 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
- REFERENCE :
- IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 57,1475,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 84 mg/kg
- SEX/DURATION :
- female 35 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
- REFERENCE :
- IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical
Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
Volume(issue)/page/year: 57,1475,1969
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