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Section 1. Chemical Product and Company Identification
    Niacinamide ascorbate
    Common Name/
    Trade Name
    Niacinamide ascorbate

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Section 3. Hazards Identification
    Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.
    Potential Acute Health
    Effects
    CARCINOGENIC EFFECTS: Not available.
    Potential Chronic Health
    MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. [Ascorbic acid]. Mutagenic for bacteria and/or yeast.
    Effects
    [Niacinamide].
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated or prolonged exposure is not known to aggravate medical condition.

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Section 4. First Aid Measures
    Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
    Eye Contact
    15 minutes. Cold water may be used. Get medical attention if irritation occurs.
    Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
    Skin Contact
    Cold water may be used.
    Not available.
    Serious Skin Contact
    If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
    Inhalation
    medical attention.
    Not available.
    Serious Inhalation
    Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
    Ingestion
    unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms
    appear.
    Not available.
    Serious Ingestion

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Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature The lowest known value is 660°C (1220°F) (Ascorbic acid).
    Not available.
    Flash Points
    Not available.
    Flammable Limits
    These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
    Products of Combustion
    Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
    Non-flammable in presence of shocks.
    Various Substances
    Risks of explosion of the product in presence of mechanical impact: Not available.
    Explosion Hazards in
    Slightly explosive in presence of open flames and sparks.
    Presence of Various
    Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    and Instructions
    Material in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated
    Special Remarks on
    temperatures
    Fire Hazards
    Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
    Special Remarks on
    explosion hazard.
    Explosion Hazards
    Niacinamide ascorbate

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Section 6. Accidental Release Measures
    Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
    Small Spill
    water on the contaminated surface and dispose of according to local and regional authority requirements.
    Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
    Large Spill
    the contaminated surface and allow to evacuate through the sanitary system.

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Section 7. Handling and Storage
    Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
    Precautions
    ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
    show the container or the label. Keep away from incompatibles such as oxidizing agents, metals, acids, alkalis.
    Keep container tightly closed. Keep container in a cool, well-ventilated area. Oxygen Sensitive Sensitive to light.
    Storage
    Store in light-resistant containers.

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Section 8. Exposure Controls/Personal Protection
    Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    Engineering Controls
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
    Personal Protection
    Personal Protection in Case Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to
    avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE
    of a Large Spill
    handling this product.
    Not available.
    Exposure Limits

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Section 9. Physical and Chemical Properties
    Solid. (Crystalline powde)        Odorless.    
    Physical state and        O dor    
    appearance
    Not available.
    Taste
    Not applicable.
    Molecular Weight
    Lemon Yellow.
    Color
    Not available.
    pH (1% soln/water)
    Not available.
    Boiling Point
    141°C (285.8°F) - 145 C.
    Melting Point
    The lowest known value is 509.85°C (949.7°F) (Ascor bic acid).
    Critical Temperature
    Weighted average: 1.58 (Water = 1)
    Specific Gravity
    Not applicable.
    Vapor Pressure
    Not available.
    Vapor Density
    Not available.
    Volatility
    Not available.
    Odor Threshold
    The product is equally soluble in oil and water.
    Water/Oil Dist. Coeff.
    Not available.
    Ionicity (in Water)
    See solubility in water, diethyl ether, n-octanol.
    Dispersion Properties
    Niacinamide ascorbate
    Soluble in cold water, hot water, n-octanol.
    Solubility
    Slightly soluble in diethyl ether.
    Solubility in Water: 285000 mg/l water or 1 g/3.5 ml water.
    Solubility in Alcohol: 1 g/20 ml alcohol.
    Very slightly soluble in chloroform.
    Sparingly soluble in Glycerine.
    Virtually insoluble in Benzene.

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Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Not available.
    Instability Temperature
    Conditions of Instability Excess heat, incompatible materials, air, oxygen, dust generation.
    Incompatibility with various Reactive with oxidizing agents, metals, acids, alkalis.
    substances
    Non-corrosive in presence of glass.
    Corrosivity
    Sensitive to light. Sensitive to Oxygen. Air sensitive. It may gradually darken upon exposure to air.
    Special Remarks on
    Reactivity
    Not available.
    Special Remarks on
    Corrosivity
    Will not occur.
    Polymerization

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Section 11. Toxicological Information
    Inhalation. Ingestion.
    Routes of Entry
    Acute oral toxicity (LD50): 2500 mg/kg [Rat].
    Toxicity to Animals
    Chronic Effects on Humans MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. [Ascorbic acid]. Mutagenic for bacteria and/or yeast.
    [Niacinamide].
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.    
    Humans
    Special Remarks on        Not available.    
    Toxicity to Animals
    May affect genetic material (mutagenic).
    Special Remarks on
    Chronic Effects on Humans May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.
    Human: passes through the placenta, excreted in maternal milk. (Ascorbic acid)
    Special Remarks on other        Acute Potential Health Effects:    
    Skin: May cause skin irritation.
    Toxic Effects on Humans
    Eyes: May cause eye irritation.
    Inhalation: May cause respiratory tract irritation.
    Ingestion: Ingestion of small amounts during normal industrial handling is a low hazard. Ingestion of large amounts
    may cause gastrointestinal tract irritation, hypermotility, diarrhea, acidification of the urine which may cause stones in
    the urinary tract and may cause renal failure . May also affect behavior (psychomotor coordination, somnolence),
    eyes(lacrimation), blood (anemia).
    Chronic Potential Health Effects:
    Ingestion: Prolonged or repeated ingestion may affect the blood/bone marrow and cause weight loss
    Niacinamide ascorbate

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Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    arise.
    The product itself and its products of degradation are not toxic.
    Toxicity of the Products
    of Biodegradation
    Not available.
    Special Remarks on the
    Products of Biodegradation

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Section 13. Disposal Considerations
    Waste must be disposed of in accordance with federal, state and local environmental control
    Waste Disposal
    regulations.

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Section 14. Transport Information
    Not a DOT controlled material (United States).
    DO T Cl assi fi cati on
    Not applicable.
    Identification
    Not applicable.
    Special Provisions for
    Transport
    DO T (Pi ctograms)

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Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    California
    cause cancer which would require a warning under the statute: No products were found.
    Proposition 65
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: No products were found.
    Other Regulations        For CAS no. 1987-71-9:    
    EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.
    Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL).
    China: Not listed on National Inventory.
    Japan: Not listed on National Inventory (ENCS).
    Korea: Not listed on National Inventory (KECI).
    Philippines: Not listed on National Inventory (PICCS).
    Australia: Not listed on AICS.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    This product is not classified according Not applicable.
    DSCL (EEC)
    to the EU regulations.
    HMIS (U.S.A.)        Health Hazard        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity        0    
    Specific hazard
    Personal Protection
    E
    Niacinamide ascorbate
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG(Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or equivalent.
    Niacinamide ascorbate
    All chemicals may pose unknown hazards and should be used withcaution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials,
    deteriorates, or becomes contaminated, it may pose hazards not mentioned inthis MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based onthe actual

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SECTION 16 - ADDITIONAL INFORMATION
N/A