安非拉酮
- 中文名称：
- 安非拉酮
- 中文别名：
- 安非拉酮;
安非泼拉酮
- 英文名称：
- DIETHYLPROPION
- 英文别名：
- diethylpropion;
Amfepramon;
2-diethylamino-1-phenyl-1-propanone;
Diethylpropione;
Dobesin;
2-(diethylamino)-1-phenylpropan-1-one;
Tepanil;
2-(Diethylamino)-1-phenyl-1-propanon;
Anorex;
Neobes;
Frekentine;
Amfepramone;
Tylinal;
2-(Dietylamino)-1-phenyl-1-propanon;
DIETHYLPROPION;
amphepramone
- CAS No.：
- 90-84-6
- 分 子 式：
-
C13H19NO
- 分 子 量：
- 205.3
- 精确分子量：
- 205.14700
- PSA：
- 20.31000
- InChI：
- The Key: XXEPPPIWZFICOJ-UHFFFAOYSA-N3
- SDS：
- 查看
安非拉酮 物化性质
- 密度：
- 0.972
- 沸点：
- 292ºC
- 闪点：
- 95ºC
安非拉酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG9450000
- CHEMICAL NAME :
- Propiophenone, 2-diethylamino-
- CAS REGISTRY NUMBER :
- 90-84-6
- BEILSTEIN REFERENCE NO. :
- 2804400
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C13-H19-N-O
- MOLECULAR WEIGHT :
- 205.33
- WISWESSER LINE NOTATION :
- 2N2&Y1&VR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 11 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - sympathomimetic
Behavioral - somnolence (general depressed activity)
Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 34,205,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 18,177,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 20,297,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France)
V.1- 1970- Volume(issue)/page/year: 17,37,1986