海关代码：

2905430000

危险类别码：

R36/37/38

安全说明：

S24/25

危险标志：

Xi

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OP2060000

CHEMICAL NAME :

Mannitol, D-

CAS REGISTRY NUMBER :

69-65-8

BEILSTEIN REFERENCE NO. :

1721898

LAST UPDATED :

199701

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C6-H14-O6

MOLECULAR WEIGHT :

182.20

WISWESSER LINE NOTATION :

Q1YQYQ 2 -BBAA -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

17143 mg/kg/2D-C

TOXIC EFFECTS :

Vascular - BP elevation not characterized in autonomic section Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

13500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9690 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

22 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

14 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7470 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Human Lymphocyte

DOSE/DURATION :

50 mmol/L

REFERENCE :

PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 79,1171,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4308 No. of Facilities: 1555 (estimated) No. of Industries: 14 No. of Occupations: 31 No. of Employees: 41268 (estimated) No. of Female Employees: 28689 (estimated)

毒理学数据：

急性毒性：男性静脉LD50：17143mg/kg/2D-C；大鼠口经LD50：13500mg/kg；大鼠静脉LD50：9690mg/kg；小鼠口经LC50：22mg/kg；小鼠腹腔LC50：14mg/kg；小鼠静脉LC50：7470mg/kg。

致突变：人淋巴细胞DNA抑制测试系统：50mmol/L。

中国海关编码：2905430000

概述：

HS:2905430000 甘露糖醇 增值税率:17.0% 退税率:9.0% 监管条件:AB 最低关税:8.0% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 包装

监管条件：

A.入境货物通关单B.出境货物通关单

检验检疫：

R.进口食品卫生监督检验S.出口食品卫生监督检验

摘要/Summary：

HS:2905430000 (2r,3r,4r,5r)-hexane-1,2,3,4,5,6-hexaol VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:8.0% General tariff:30.0%

分子结构数据

1、 摩尔折射率：38.89

2、 摩尔体积（cm³/mol）：114.1

3、 等张比容（90.2K）：360.7

4、 表面张力（dyne/cm）：99.8

5、 极化率（10-24cm3）：15.41

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:6

3.氢键受体数量:6

4.可旋转化学键数量:5

5.互变异构体数量:无

6.拓扑分子极性表面积121

7.重原子数量:12

8.表面电荷:0

9.复杂度:105

10.同位素原子数量:0

11.确定原子立构中心数量:4

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  D-甘露醇红外图谱(IR1)
• 
  D-甘露醇红外图谱(IR2)
• 
  D-甘露醇质谱(MS)
• 
  D-甘露醇核磁图(¹³CNMR)
• 
  D-甘露醇Raman光谱
• 
  D-甘露醇核磁图(¹HNMR)