Section I.Chemical Product and Company Identification
Chemical Name Physostigmine free base
Portland OR
Synonym Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-
1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-
(CA INDEX NAME); Eserine
Chemical Formula C15H21N3O2
57-47-6
CAS Number
Section II. Composition and Information on Ingredients
Chemical Name CAS Number Percent (%) TLV/PEL Toxicology Data
Physostigmine free base 57-47-6 Min. 98.0 Not available. Rat LD50 (oral) 4500 µg/kg
(HPLC,T) Mouse LD50 (oral) 3 mg/kg
Rabbit LD50 (oral)11200 µg/kg
Section III. Hazards Identification
Acute Health Effects Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health Effects CARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Reproductive effects.
Rat TDLo Intraperitoneal 333 µg/kg, male 1 day prior to mating
TOXIC EFFECTS:
Effects on Fertility - Mating performance
Mouse TDLo Intraperitoneal 50 µg/kg, female 13 days of pregnancy
TOXIC EFFECTS:
Effects on Newborn - Biochemical and metabolic
Effects on Newborn - Behavioral
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
many human organs.
Section IV. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
Skin Contact
and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately.
Inhalation If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Section V. Fire and Explosion Data
Not available.
May be combustible at high temperature. Auto-Ignition
Flammability
Flammable Limits Not available.
Flash Points 100°C (212°F)
Combustion Products These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
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Physostigmine free base
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Section VI. Accidental Release Measures
Spill Cleanup Highly toxic material. Air and light sensitive material. Heat sensitive material.
Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
Instructions
vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all sources of ignition. Consult
federal, state, and/or local authorities for assistance on disposal.
Section VII. Handling and Storage
HIGHLY TOXIC. AIR AND LIGHT SENSITIVE. HEAT SENSITIVE MATERIAL. STORE UNDER INERT GAS. Keep locked
Handling and Storage
up. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
Information
place. Avoid excessive heat and light. DO NOT ingest. Do not breathe dust. Wear suitable protective clothing. If ingested,
seek medical advice immediately and show the container or the label. Treat symptomatically and supportively.
Always store away from incompatible compounds such as oxidizing agents, metals, acids, alkalis (bases).
Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
Personal Protection
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits Not available.
Section IX. Physical and Chemical Properties
Solid. (Off-white crystal.) Solubility
Physical state @ 20°C Very soluble in dichloromethane.
Soluble in ether, chloroform,
Not available. benzene, alcohol, oils.
Specific Gravity
Slightly soluble in water.
Molecular Weight 275.35 Partition Coefficient LOG Pow: 2.21
Boiling Point Not available. Not applicable.
Vapor Pressure
Melting Point 105°C (221°F) Vapor Density Not available.
Not available. Not available.
Refractive Index Volatility
Critical Temperature Not available. Odor Not available.
Not available. Not available.
Viscosity Taste
Section X. Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Avoid excessive heat and light. Air and light sensitive. Store under inert gas.
Turns red on exposure to heat, light, air, and on contact with traces of metals.
Incompatibilities
Reactive with oxidizing agents, metals, acids, alkalis (bases).
Section XI. Toxicological Information
TJ2100000
RTECS Number
Routes of Exposure Eye Contact. Ingestion. Inhalation.
Rat LD50 (oral) 4500 µg/kg
Toxicity Data
Mouse LD50 (oral) 3 mg/kg
Rabbit LD50 (oral)11200 µg/kg
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Reproductive effects.
Rat TDLo Intraperitoneal 333 µg/kg, male 1 day prior to mating
TOXIC EFFECTS:
Effects on Fertility - Mating performance
Mouse TDLo Intraperitoneal 50 µg/kg, female 13 days of pregnancy
TOXIC EFFECTS:
Effects on Newborn - Biochemical and metabolic
Effects on Newborn - Behavioral
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
human organs.
Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Acute Toxic Effects
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
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Physostigmine free base
Section XII. Ecological Information
Ecotoxicity Not available.
Not available.
Environmental Fate
Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.
Section XIV. Transport Information
DOT Classification DOT CLASS 6.1: Toxic material.
PIN Number
Proper Shipping Name Alkaloids, solid, n.o.s.
I RQ = 100 (45.4)
Packing Group (PG)
DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.
(EPA)
WHMIS Classification CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
On NDSL.
(Canada)
EINECS Number (EEC) 200-332-8
EEC Risk Statements R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.
SECTION 16 - ADDITIONAL INFORMATION
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