利福布丁
- 中文名称：
- 利福布丁
- 中文别名：
- 利福布丁;
利福布汀;
利福布汀(安莎霉素);
4-N-异丁基螺哌啶利福霉素 S;
螺哌啶利福霉素S;
4-脱氧-3,4-[2-螺(N-异丁基-4-哌啶基)]-(1H)-咪唑并-(2,5-双氢)利福霉素S
- 英文名称：
- Rifabutin
- 英文别名：
- rifabutin;
Rifabutin;
4-deoxo-3,4-[2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-rifamicin S;
Ansamycin;
RIFABUTINE;
Mycobutin;
lm427;
Rifabatin;
antibioticlm427;
1',4-didehydro-1-desoxi-1,4-di-hydro-5'-(2-methyl-propyl)-1-oxo-rifamycin;
Ansatipine;
6,9-dihydro-5,17,19,21-tetrahydroxy-8,9-[2-spiro-(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-23-methoxy-2,4,12,16,18,20,22-heptamethyl-6-oxo-2,7-epoxypentadeca-[1,11,13]-trienimine-2H-furo[2',3',7,8]nafto[1,2-d]imidazolo-2,4'-piperidine-5,10,26. (3H,9H)-trione-16-acetate
- CAS No.：
- 72559-06-9
- 分 子 式：
-
C46H62N4O11
- 分 子 量：
- 847.00
- 精确分子量：
- 846.44200
- PSA：
- 205.55000
- InChI：
- InChI=1/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)55)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-543
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
利福布丁 物化性质
- 外观与性状：
- 红色-紫罗兰色结晶粉末
- 密度：
- 1.339g/cm3
- 熔点：
- 169-171ºC
- 沸点：
- 969.589ºC at 760 mmHg
- 闪点：
- 540.188ºC
- 折射率：
- 1.623
利福布丁 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VJ6700000
- CHEMICAL NAME :
- Rifamycin XIV,
1,4-dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl
)-1-oxo-
- CAS REGISTRY NUMBER :
- 72559-06-9
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C46-H62-N4-O11
- MOLECULAR WEIGHT :
- 847.12
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 60 mg/kg/14D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 348,685,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 84 mg/kg/14D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 348,685,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3322 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 266 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9100 mg/kg/13W-C
- TOXIC EFFECTS :
- Liver - other changes
Kidney, Ureter, Bladder - other changes
Blood - changes in spleen
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29120 mg/kg/1Y-I
- TOXIC EFFECTS :
- Blood - normocytic anemia
Endocrine - changes in spleen weight
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47 mg/kg/1Y-C
- TOXIC EFFECTS :
- Blood - normocytic anemia
Blood - changes in spleen
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 47,1,1995
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