尼可待因
- 中文名称：
- 尼可待因
- 中文别名：
- 尼可待因
- 英文名称：
- nicocodine
- 英文别名：
- [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] pyridine-3-carboxylate;
Nicocodeine;
EINECS 222-990-5;
O-nicotinoyl-codeine;
NICOCODINE;
Nicocodinum [INN-Latin];
Lyopect;
DEA No. 9309;
Nicocodina [INN-Spanish];
Codeine,nicotinate (ester);
Nicotinic acid,ester with codeine;
RC 146
- CAS No.：
- 3688-66-2
- 分 子 式：
-
C24H24N2O4
- 分 子 量：
- 404.464
- 精确分子量：
- 404.17400
- PSA：
- 60.89000
- EINECS：
- 222-990-5
- InChI：
- The Key: RYBGRHAWFUVMST-MJFIPZRTSA-N3
- SDS：
- 查看
尼可待因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD1225000
- CHEMICAL NAME :
- Morphinan-6-alpha-ol,
7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-,
nicotinate (ester)
- CAS REGISTRY NUMBER :
- 3688-66-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C24-H24-N2-O4
- MOLECULAR WEIGHT :
- 404.50
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ JO1 P1 FOV-
CT6NJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 143,466,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 840 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 143,466,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 143,466,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 48 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 143,466,1963