羟甲烯龙,434-07-1，生产厂家，价格-洛克化工网移动版

羟甲烯龙

中文名称：: 羟甲烯龙

中文别名：: 羟甲烯龙;
枸橼酸托法替尼;
17β-羟基-2-羟亚甲基-17α-甲基-5α-雄甾(烷)-3-酮;
2-羟亚甲基-17α-甲基-5α-雄甾(烷)-17β-醇-3-酮;
17β-Hydroxy-2-(hydroxymethylene)-17-methyl-5α-androstan-3-one

英文名称：: Androstan-3-one,17-hydroxy-2-(hydroxymethylene)-17-methyl-, (5a,17b)-

英文别名：: oxymetholone;
Stanozolol impurity B;
Becorel;
Anadrol;
Raboral;
Roboral;
Adroidin;
Adroyd;
Oxymetholone;
Anadroyd

CAS No.：: 434-07-1

分子式：: C₂₁H₃₂O₃

分子量：: 332.48

精确分子量：: 332.23500

PSA：: 57.53000

MDL：: MFCD00133083

EINECS：: 207-098-6

InChI：: InChI=1/C21H32O3/c1-19-11-13(12-22)18(23)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,22,24H,4-11H2,1-3H3/b13-12-/t14-,15+,16-,17-,19-,20-,21-/m0/s13

危险品标志：

风险术语：: R63

安全术语：: S22 S26 S53 S36/S37/S39

分子结构式：

SDS：: 查看

羟甲烯龙制备方法及用途

制备方法

可用番麻皂素或剑麻皂素经乙酰化、还原、开环、氧化、水解、消除、肟化、重排、水解、加成、氧化、水解、缩合等多步反应制得该品。

合成制备方法

可用番麻皂素或剑麻皂素经乙酰化、还原、开环、氧化、水解、消除、肟化、重排、水解、加成、氧化、水解、缩合等多步反应制得该品。

用途简介

康力龙的中间体。本身为蛋白同化激素类药物,能促进蛋白质合成和抑制蛋白质异生,并能降低血胆固醇、减少钙磷排泄和减轻骨髓抑制,促进发育,促进组织新生和肉芽形成。对肾上腺皮质激素长期使用引起的肾上腺皮质功能减退有预防及对抗作用。

用途

康力龙的中间体。本身为蛋白同化激素类药物，能促进蛋白质合成和抑制蛋白质异生，并能降低血胆固醇、减少钙磷排泄和减轻骨髓抑制，促进发育，促进组织新生和肉芽形成。对肾上腺皮质激素长期使用引起的肾上腺皮质功能减退有预防及对抗作用。

羟甲烯龙物化性质

外观与性状：: 白色结晶粉末
密度：: 1.169g/cm3
熔点：: 172-180°C
沸点：: 465.9ºC at 760mmHg
闪点：: 249.7ºC
水溶解性：: <0.1 g/100 mL at 23℃
折射率：: 38 ° (C=1, CHCl3)
蒸汽压：: 1.23E-10mmHg at 25°C
其它信息：: 一、物性数据

性状：白色结晶性粉末，无嗅

密度（g/mL,25/4℃）：不可用

相对蒸汽密度（g/mL,空气=1）：不可用

熔点（ºC）：173-176

沸点（ºC,常压）：不可用

沸点（ºC,5.2kPa）：不可用

折射率：不可用

闪点（ºC）：不可用

比旋光度（º）：不可用

自燃点或引燃温度（ºC）：不可用

蒸气压（kPa,25ºC）：不可用

饱和蒸气压（kPa,60ºC）：不可用

燃烧热（KJ/mol）：不可用

临界温度（ºC）：不可用

临界压力（KPa）：不可用

油水（辛醇/水）分配系数的对数值：不可用

爆炸上限（%,V/V）：不可用

爆炸下限（%,V/V）：不可用

溶解性：不溶于水，易溶于氯仿，溶于二氧六环、植物油，略溶于乙醇、乙醚

羟甲烯龙安全信息

海关代码：: 2937290023
WGK_Germany：: 3
德国有关水污染物质的分类清单
危险类别码：: R40
安全说明：: S53-S22-S26-S36/37/39
RTECS号：: BV8060000
安全标志：: S22:不要吸入粉尘。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S53:避免暴露——使用前先阅读专门的说明。
:
危险标志：: T: Toxic;

羟甲烯龙毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8060000

CHEMICAL NAME :: 5-alpha,17-beta-Androstan-3-one, 17-hydroxy-2-(hydroxymethylene)-17-methyl-

CAS REGISTRY NUMBER :: 434-07-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C21-H32-O3

MOLECULAR WEIGHT :: 332.53

WISWESSER LINE NOTATION :: L E5 B666 OVTJ A1 E1 FQ F1 P1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 46 mg/kg/14W-I

TOXIC EFFECTS :: Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 270 mg/kg/9W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2336 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - jaundice (or hyperbilirubinemia) hepatocellular Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 3050 mg/kg/3Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 3735 mg/kg/3Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 128 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 28 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 30 mg/kg

SEX/DURATION :: female 1-3 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997 *** REVIEWS *** IARC Cancer Review:Animal No Adequate Data IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,96,1987 TOXICOLOGY REVIEW BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 8,259,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6172 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 742 (estimated) No. of Female Employees: 359 (estimated)

毒理学数据：

二、毒理学数据：

急性毒性：不可用。

生态数据：

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

羟甲烯龙分子结构与计算化学数据

分子结构数据

1、摩尔折射率：95.89

2、摩尔体积（m³/mol）：284.2

3、等张比容（90.2K）：757.0

4、表面张力（dyne/cm）：50.3

5、极化率（10^-24cm³）：38.01

羟甲烯龙下游产品

雄异恶唑; 雄异噁唑 17-Methyl-5α-androst-2-eno[2,3-d]isoxazol-17β-ol

羟甲烯龙

羟甲烯龙制备方法及用途

制备方法

合成制备方法

用途简介

用途

羟甲烯龙物化性质

羟甲烯龙安全信息

羟甲烯龙毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

羟甲烯龙分子结构与计算化学数据

分子结构数据

羟甲烯龙下游产品

羟甲烯龙表征图谱

推荐供应商

羟甲烯龙

羟甲烯龙 制备方法及用途

制备方法

合成制备方法

用途简介

用途

羟甲烯龙 物化性质

羟甲烯龙 安全信息

羟甲烯龙 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

羟甲烯龙 分子结构与计算化学数据

分子结构数据

羟甲烯龙 下游产品

羟甲烯龙 表征图谱

推荐供应商

羟甲烯龙制备方法及用途

羟甲烯龙物化性质

羟甲烯龙安全信息

羟甲烯龙毒理性

羟甲烯龙分子结构与计算化学数据

羟甲烯龙下游产品

羟甲烯龙表征图谱