维司力农,81840-15-5，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

毒理性

结构与计算化学

上游产品

下游产品

维司力农

中文名称：: 维司力农

中文别名：: 维司力农;
3,4-二氢-6-[4-(3,4-二甲氧苯甲酰)-1-哌嗪基]-2(1H)-喹啉酮;
威那利酮

英文名称：: Vesnarinone

英文别名：: 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one;
vesnarinone;
Vesnarinonum [Latin];
Piteranometozine;
6-[4-(3,4-dimethoxy-benzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril;
Arkin-Z;
Vesnarinona [Spanish];
3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline;
DRG-0210

CAS No.：: 81840-15-5

分子式：: C22H25N3O4

分子量：: 395.45

精确分子量：: 395.18500

PSA：: 71.11000

InChI：: The Key: ZVNYJIZDIRKMBF-UHFFFAOYSA-N3

分子结构式：

SDS：: 查看

维司力农制备方法及用途

制备方法

以6-氨基-3，4-二氢-2(1H)-喹啉酮为原料。将6-氨基-3，4-二氢-2(1H)-喹啉酮(21.1g，0.13mo1)和双(伊溴乙基)胺氢溴酸盐(40.5g，0.13mo1)溶于150ml乙醇，回流搅拌8h。冷却，加入碳酸钠(13.8g，0.13mo1)，再回流搅拌8h。冷至室温，过滤收集析出的沉淀，用乙醇洗，乙醇-水重结晶，得26.4g无色针状结晶的3，4-二氢-6-(1-哌嗪基)-2(1H)-喹啉酮氢溴酸盐，收率64%，熔点289--293℃(分解)。将上述得到的喹啉酮衍生物(3.1g，0.010mo1)和三乙胺(2.2g，0.022mo1)溶于40ml无水二甲基甲酰胺，在冰浴冷却和搅拌下，滴加3，4-二甲氧苯甲酰氯(2.2g，0.0l 1mo1)在10ml无水二甲基甲酰胺中的溶液。加毕，在室温下搅拌1h。将反应液倾入冰水，用氯仿提取。提取液水洗，无水硫酸钠干燥，减压浓缩。剩余物用硅胶层析，氯仿-甲醇(100：1)洗脱。然后再用乙醇-氯仿重结晶，得2.7g无色颗粒状结晶的维司力农，收率70%，熔点238～239.5℃。

合成制备方法

以6-氨基-3，4-二氢-2(1H)-喹啉酮为原料。将6-氨基-3，4-二氢-2(1H)-喹啉酮(21.1g，0.13mo1)和双(伊溴乙基)胺氢溴酸盐(40.5g，0.13mo1)溶于150ml乙醇，回流搅拌8h。冷却，加入碳酸钠(13.8g，0.13mo1)，再回流搅拌8h。冷至室温，过滤收集析出的沉淀，用乙醇洗，乙醇-水重结晶，得26.4g无色针状结晶的3，4-二氢-6-(1-哌嗪基)-2(1H)-喹啉酮氢溴酸盐，收率64%，熔点289--293℃(分解)。
将上述得到的喹啉酮衍生物(3.1g，0.010mo1)和三乙胺(2.2g，0.022mo1)溶于40ml无水二甲基甲酰胺，在冰浴冷却和搅拌下，滴加3，4-二甲氧苯甲酰氯(2.2g，0.0l 1mo1)在10ml无水二甲基甲酰胺中的溶液。加毕，在室温下搅拌1h。将反应液倾入冰水，用氯仿提取。提取液水洗，无水硫酸钠干燥，减压浓缩。剩余物用硅胶层析，氯仿-甲醇(100：1)洗脱。然后再用乙醇-氯仿重结晶，得2.7g无色颗粒状结晶的维司力农，收率70%，熔点238～239.5℃。

用途简介

能增强收缩力而不提高心律,因而较少引起心肌耗氧的增加.用于轻至中度慢性心力衰竭.本品与典型的磷酸二酯酶抑制剂不同,其特点能增强收缩力而不提高心率,较少引起心肌耗氧的增加.可明显降低死亡率和心力衰竭恶化,并改善生活质量.适用于轻度、中度慢性心力衰竭的治疗.

用途

能增强收缩力而不提高心律,因而较少引起心肌耗氧的增加.用于轻至中度慢性心力衰竭.
本品与典型的磷酸二酯酶抑制剂不同,其特点能增强收缩力而不提高心率,较少引起心肌耗氧的增加.可明显降低死亡率和心力衰竭恶化,并改善生活质量.适用于轻度、中度慢性心力衰竭的治疗.

维司力农物化性质

密度：
1.246g/cm3

沸点：
678.3ºC at 760 mmHg

闪点：
364ºC

折射率：
1.601

其它信息：

1.性状：从乙醇-氯仿得无色颗粒状结晶。
2.熔点238.1-239.5℃.也有无臭无味的淡黄色结晶性粉末,熔点238.1-239.8℃.
3.UV最大吸收(甲醇，乙醇，氯仿)：271nm(ε25100，25200，23000，C=10μg/m1)。
4.溶解度%(25℃)：冰醋酸18.68,氯仿14.19,苄醇5.913,N-甲基-2-吡咯啉酮3.407,二甲亚砜2.509,环丁砜1.229,二甲基甲酰胺1.179,二氧六环0.1653,甲醇0.1151,丙酮0.06389,乙醇0.04005,水0.002086。
5.pKa2.86。

维司力农毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL4490000

CHEMICAL NAME :
Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo- 6-quinolinyl)-

CAS REGISTRY NUMBER :
81840-15-5

LAST UPDATED :
199612

DATA ITEMS CITED :
16

MOLECULAR FORMULA :
C22-H25-N3-O4

MOLECULAR WEIGHT :
395.50

WISWESSER LINE NOTATION :
T66 BNVT&J H- AT6N DNTJ DVR CO1 DO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
>7594 mg/kg

TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
>1200 mg/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
>3 gm/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
79300 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
>7594 mg/kg

TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
>1200 mg/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
>1200 mg/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
56300 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
>3 gm/kg

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
63300 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
>3 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,922,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
1100 mg/kg

SEX/DURATION :
female 7-17 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,875,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
330 mg/kg

SEX/DURATION :
female 7-17 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,875,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
11 gm/kg

SEX/DURATION :
female 7-17 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,875,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
3900 mg/kg

SEX/DURATION :
female 6-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,898,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
13 gm/kg

SEX/DURATION :
female 6-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,898,1987

维司力农分子结构与计算化学数据

分子结构数据

1、摩尔折射率：108.67
2、摩尔体积（cm³/mol）：317.1
3、等张比容（90.2K）：843.9
4、表面张力（dyne/cm）：50.1
5、极化率（10-24cm3）：43.08

计算化学数据

1.疏水参数计算参考值（XlogP）:2.1
2.氢键供体数量:1
3.氢键受体数量:5
4.可旋转化学键数量:4
5.互变异构体数量:3
6.拓扑分子极性表面积71.1
7.重原子数量:29
8.表面电荷:0
9.复杂度:593
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1

维司力农上游产品

6-氨基-3,4-二氢-2(1H)-喹啉酮 3,4-二甲氧基苯甲酰氯

维司力农下游产品

3,4-二甲氧基苯甲酸乙酯 3,4-二甲氧基苯甲酸

推荐供应商

苏州贝昶生物科技有限公司

Vesnarinone
联系人：Sales
电  话：18013506594
手  机：18013506594
Cas号：81840-15-5
包装：按照要求g,按照要求g,按照要求g,按照要求g,按照要求g
纯度：98%
价格：洽谈
范德(北京)生物科技有限责任公司

81840-15-5
联系人：王
电  话：15911056312
手  机：15911056312
Cas号：81840-15-5
包装：1mg
纯度：96.06%
价格：1,290.0元

维司力农

维司力农 制备方法及用途

制备方法

合成制备方法

用途简介

用途

维司力农 物化性质

维司力农 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

维司力农 分子结构与计算化学数据

分子结构数据

计算化学数据

维司力农 上游产品

维司力农 下游产品

推荐供应商

苏州贝昶生物科技有限公司

Vesnarinone

范德(北京)生物科技有限责任公司

81840-15-5

维司力农制备方法及用途

维司力农物化性质

维司力农毒理性

维司力农分子结构与计算化学数据

维司力农上游产品

维司力农下游产品