海关代码：

2930400000

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R33

安全说明：

S24/25

RTECS号：

PD0457000

安全标志：

S22:不要吸入粉尘。
S24/25:防止皮肤和眼睛接触。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

PD0457000

CHEMICAL NAME :

Methionine, L-

CAS REGISTRY NUMBER :

63-68-3

LAST UPDATED :

199710

DATA ITEMS CITED :

24

MOLECULAR FORMULA :

C5-H11-N-O2-S

MOLECULAR WEIGHT :

149.23

WISWESSER LINE NOTATION :

QVYZ2S1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

36 gm/kg

TOXIC EFFECTS :

Behavioral - changes in motor activity (specific assay) Immunological Including Allergic - uncharacterized

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4328 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>9500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

21600 mg/kg/60D-I

TOXIC EFFECTS :

Liver - changes in liver weight Blood - leukopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

26100 mg/kg

SEX/DURATION :

female 10-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

14720 mg/kg

SEX/DURATION :

female 10-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

35 gm/kg

SEX/DURATION :

female 2 week(s) pre-mating female 1-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TEST SYSTEM :

Rodent - guinea pig

DOSE/DURATION :

500 mg/kg

REFERENCE :

JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,190a,1970 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81891 No. of Facilities: 273 (estimated) No. of Industries: 5 No. of Occupations: 17 No. of Employees: 12017 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81891 No. of Facilities: 1116 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 28520 (estimated) No. of Female Employees: 17038 (estimated)

毒理学数据：

急性毒性：大鼠口经LD50：36 mg/kg；大鼠腹腔LD50：4328 mg/kg；小鼠腹腔LC50：>9500 mg/kg；

繁殖：大鼠口经TDLo：26100 mg/kgSEX/DURATION : female 10-20 day(s) after conception；

分子结构数据

 1、   摩尔折射率：38.26

2、   摩尔体积（cm³/mol）：123.7

3、   等张比容（90.2K）：329.9

4、   表面张力（dyne/cm）：50.5

5、   极化率（10^-24cm³）：15.17

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:4

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积88.6

7.重原子数量:9

8.表面电荷:0

9.复杂度:97

10.同位素原子数量:0

11.确定原子立构中心数量:1

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  L-甲硫氨酸红外图谱(IR1)
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  L-甲硫氨酸红外图谱(IR2)
• 
  L-甲硫氨酸质谱(MS)
• 
  L-甲硫氨酸核磁图(¹³CNMR)