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配方类型: DRUGS
配方说明: Tablets (Phenobarbitone, 50 mg)
配方组成: Dicalcium Phosphate Dihydrate/-
Magnesium Stearate/0.5
Tablet Wt./200 mg
Phenobarbitone/25.0
Relative Wt. Standard Deviation/0.60%
Ejection Force/250 N
Lactose (extra fine crystalline)/49.3
Crushing Strength (Schleuniger)/7.9 kg
Friability (Roche, 100 rotations)/0.4%
Disintegrating Time (USP XIX)/20 s
Disintegrating Time (without using discs)/21 s
"Primojel"/2.5
Microcrystalline Cellulose/22.5
Prednisone (micronized)/-
Colloidal Silica/0.
配制方法: Prepare by direct compression using an instrumented single punch tableting machine at a compression force of 20 kN. Tablet diameter: 7 mm for the prednisone tablets and 9 mm for the phenobarbitone tablets.
After storage of the tablets at extreme humid conditions, 8 weeks 20 C and 85% relative humidity, the disintegration time was 20 s for the prednisone tablets and 29 s for the phenobarbitone tablets.

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