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配方类型: DRUGS
配方说明: Aspirin Tablet (Childrens)
配方组成: Sodium saccharin/7 g
Stearic acid/0.3
Flavor/q.s.
Mannitol granulation/99.1
10% Acacia solution/230 ml
Mannitol, USP (powdered)/1000 g
Starch/10.6
Aspirin (20-mesh)/81.0
Talc/8.0
配制方法: Granulation of excipient: Granulate the mannitol and saccharin with the acacia solution, dry at 110f and pass through a 20-mesh screen.
Preparation of aspirin mixture: Mix the aspirin with the dried mannitol granulation. Take extreme care to avoid moisture pick-up. Add the flavor to the starch, mixing thoroughly. Add the talc and stearic acid, screened to 100-mesh, to the flavor-starch mixture. Blend this combination of flavoring, starch, talc stearic acid with the mannitol-aspirin mixture.
Compression: compress using 11/32 inch standard concave punch to a hardness of 4-6 kg (Strong-Cobb-Arner tester).

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