化学配方数据库
配方类型: | DRUGS |
配方说明: | Aspirin Tablet (Childrens) |
配方组成: | Sodium saccharin/7 g Stearic acid/0.3 Flavor/q.s. Mannitol granulation/99.1 10% Acacia solution/230 ml Mannitol, USP (powdered)/1000 g Starch/10.6 Aspirin (20-mesh)/81.0 Talc/8.0 |
配制方法: | Granulation of excipient: Granulate the mannitol and saccharin with the acacia solution, dry at 110f and pass through a 20-mesh screen. Preparation of aspirin mixture: Mix the aspirin with the dried mannitol granulation. Take extreme care to avoid moisture pick-up. Add the flavor to the starch, mixing thoroughly. Add the talc and stearic acid, screened to 100-mesh, to the flavor-starch mixture. Blend this combination of flavoring, starch, talc stearic acid with the mannitol-aspirin mixture. Compression: compress using 11/32 inch standard concave punch to a hardness of 4-6 kg (Strong-Cobb-Arner tester). |
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