- 产品名称
- 依曲韦林
- CAS NO
- 269055-15-4
- 中文别名
- 4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈
- 英文名称
- Benzonitrile,4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-
- 英文别名
- Etravirine;Intelence; R 165335; TMC 125
- 分子式
- C20H15BrN6O
- 分子量
- 0
- EINECS
- 682-331-6
- 熔点
- 265oC (dec.)
- 沸点
- 637.4oC at 760mmHg
- 毒性
依曲韦林269055-15-4；4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈
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436133-68-5
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1011301-27-1
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1011557-82-6
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312756-74-4
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178946-89-9
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24144-92-1
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168425-64-7
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728865-23-4
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851983-85-2
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1429881-91-3
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该产品相关资料：
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中文名称:
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4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈
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中文同义词:
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4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈;依曲韦林;依曲韦林;依曲韦林-D6;依曲韦林合成工艺
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英文名称:
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4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile
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英文同义词:
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4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile;Etravirine;Etravirine（TMC-125）;R 165335;TMC 125;4-(6-amino-5-bromo-2-(4-cyanobenzyl)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, Etravirine;4-[[6-AMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl]oxy]-3,5-diMethyl -;4-[[6-aMino-5-broMo-2-[(4-cyanophenyl)aMino]-4-pyriMidinyl]oxy]-3, 5 –diMethylbenzonitrile/Etravirine
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CAS号:
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269055-15-4
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分子式:
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C20H15BrN6O
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分子量:
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435.284
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EINECS号:
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1592732-453-0
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相关类别:
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新型抗HIV药;原料药;信号转导通路激酶抑制剂;杂环类;原料药中间体;小分子抑制剂;小分子抑制剂，天然产物;有机原料;微生物Microbiology;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase
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Mol文件:
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269055-15-4.mol
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4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈 性质
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熔点
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.265°C (dec.)
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储存条件
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-20°C Freezer
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4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈 用途与合成方法
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生物活性
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Etravirine (TMC125)是一种非核苷类逆转录酶抑制剂(NNRTI)，用于治疗HIV。
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体外研究
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Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes circulating recombinant forms a group O virus.
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体内研究
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Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group.
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结构式：
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依曲韦林
4-[[2-[(4-氰基苯基)氨基]-5-溴-6-氨基]-4-嘧啶基氧基]-3,5-二甲基苯腈
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(1R,3R)-1-(1,3-苯并二氧戊环-5-基)-2-(氯乙酰基)-2,3,4,9-四氢-1H-吡啶并[3,4-B]吲哚-3-羧酸甲酯
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温馨提示：仅用于科研哦，不能用于人体治疗、药物开发和其他商业用途my2018.11.28
