产品名称

丁溴东莨菪碱

CAS NO

149-64-4

中文别名

(-)-N-Butylscopolamine bromide; Hyoscine N-butyl bromide

英文名称

3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide (1:1), (1a,2b,4b,5a,7b)-

英文别名

1aH,5aH-Tropanium, 8-butyl-6b,7b-epoxy-3a-hydroxy-,bromide, (-)-tropate (8CI); 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, [7(S)-(1a,2b,4b,5a,7b)]-; 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-methyl-, bromide, (1a,2b,4b,5a,7b)- (9CI); N-Butylscopolammonium bromide (6CI,7CI);Tropic acid, (-)-, ester with 8-butyl-6b,7b-epoxy-3a-hydroxy-1aH,5aH-tropanium bromide (8CI); (-)-Scopolaminebutylbromide; Amisepan; Buscapine; Buscol; Buscolamin; Buscolysin; Buscolysine;Buscopan; Butylmin; Butylscopolamine bromide; Butylscopolammonium bromide;Donopon; Hyoscine butobromide; Hyoscine butyl bromide; Joscine; Monospan;N-Butylhyoscine bromide; N-Butylhyoscinium bromide; N-Butylscopolamine bromide;N-Butylscopolaminium bromide; Scobro; Scobron; Scobutil; Scobutyl; Scopolaminebromobutylate; Scopolamine butobromide; Scopolamine butyl bromide; Scopolamine-N-butylbromide; Scopolan; Sparicon; Sporamin

分子式

C₂₁H₃₀NO₄.Br

分子量

440.37

EINECS

205-744-1

熔点

142-1440C

沸点

毒性

二、毒理学数据：1、急性毒性：大鼠经口LD50：1040 mg/kg；大鼠皮下LD50：450 mg/kg；大鼠静脉LD50：24 mg/kg；小鼠经口LD50：1170 mg/kg；小鼠腹腔LD50：65 mg/kg；小鼠皮下LD50：243 mg/kg；小鼠静脉LD50：10300 ug/kg。

丁溴东莨菪碱 Scopolamine Butyl bromide

Chinese name : acid butyl bromide scopolamine Source : white mandala Solanaceae plants of Datura metm l dried flower Flos daturae HPLC detection of the content : acid butyl bromide scopolamine 99 Appearance : white almost white crystalline powder Chemical name : 1-alpha-H,5-alpha-H-Tropanium,8-butyl-6-beta,7-beta-epoxy- 3-alpha-hydroxy-,bromide,--tropate English name : Scopolamine Butyl bromide CAS Reg. : 149-64-4 Molecular formula : C21-H30-N-O4. Br Molecular weight : 440.375 Melting point : 169-173 ° c Property description : odor : odorless almost odorless ; solubility : soluble in chloroform and water, slightly soluble in ethanol. Specific rotation : - 18 ° to - 20 ° 0.1gml, Ph : PH:5.5-6.50.1gml Storage conditions : cool and dry place, away from light. Validity : 24 months. [ Product description ] This product is peripheral anticholinergic drugs, not including spasmolysis to smooth muscle, there is blocking the function of neural and neuromuscular, but on the central role of weak. This seismic and arecoline induced central function of the amount, about their week 18 anti - casting. Its confrontation acetyl choline caused of away from body intestinal contraction of role about for atropine of 110-120 , but on intestinal smooth muscle to muscle sexual solutions zhijing role is more atropine for strong , so can selective to mitigation gastrointestinal road , and biliary and the urinary road smooth muscle of spasm and suppression its creeping , and on heart , and pupil and salivary glands of effect smaller , so rarely appears similar atropine caused of central nervous excited , and spread pupil , and suppression saliva secretion , side effects . This oral difficult to absorb. After intramuscular intravenous, usually in the efficacy of 3-5 minutes, maintaining time 2-6 hours. 1. This product is applicable to the stomach, duodenum, colon preoperative preparation of fiber endoscopy, Endoscopic Retrograde Cholangiopancreatography and the stomach, duodenum, Small Bowel Enema colonic gas and barium computer abdominal computed tomography scan CT scan in preoperative preparation, can effectively reduce inhibit gastrointestinal peristalsis, make check satisfaction, image clarity, high success rate. 2. For the treatment of gastrointestinal spasm due to various causes, renal colic, Biliary colic, gastrointestinal peristalsis with hyperthyroidism, good efficacy, stronger than effects of atropine, scopolamine, with fast onset, characteristic of small side - effects