产品名称

奎诺二甲基丙烯酸酯

CAS NO

53188-07-1

中文别名

(±)-6-羟基-2,5,7,8-四甲基色烷-2-羧酸

英文名称

2H-1-Benzopyran-2-carboxylicacid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-

英文别名

2H-1-Benzopyran-2-carboxylicacid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, (?à)-;(R,S)-6-Hydroxy-2,5,7,8-tetramethyl-2-chromanecarboxylic acid; (?à)-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicacid; (?à)-Trolox;6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; Trolox; Trolox C

分子式

C₁₄H₁₈O₄

分子量

250.29

EINECS

258-422-8

熔点

187-189 °C(lit.)

沸点

450.3 °C at 760mmHg

毒性

Trolox is an antioxidant derived from water-soluble vitamin E, with oxygen quenching activity. The activity of Trolox ranges between ferulic acid (sc-204753) p-coumaric acid (sc-215648). Studies show that lipid peroxidation, cytotoxicity, apoptosis induced by cytochrome P450 2E1 in Hep G2 cells is blocked in the presence of Trolox. It has been observed that Trolox can quench free radicals inhibit methylmercury (MeHg)-induced reactive oxygen species (ROS) generation in C6 glial cells. In addition, Trolox has demonstrated the ability to reduce cytotoxicity of Microcystis aeruginosa microcystin-LR in Artemia franciscana nauplii. 

Technical Information

Appearance: White 

Physical State: Solid 

Solubility: Soluble in 100% ethanol (25 mg/ml), methanol, water(slightly), DMSO (~20 mg/ml), DMF (~20 mg/ml), PBS( pH7.2) (~3 mg/ml). 

Storage: Store at -20° C 

Melting Point: 187-189 °C (lit.) 

Boiling Point: 450.26 °C at 760 mmHg 


Density: 1.22 g/cm3 

Refractive Index: n20D 1.57 

IC50: Rattus norvegicus: EC5050 = 77.8 μM; COX2: IC50 = 150 nM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 3.6 μM (human); Bos taurus: IC50 = 5 μM; COX1: IC50 = 130 nM (human); Rattus norvegicus: IC50 = 14 μM; Brain: IC50 = 41.57 μM (Rattus norvegicus); MCF7 (Breast carcinoma cells): IC50 = 1461 μM (human); Radical scavenging activity: IC50 = 10.6 μM