产品名称

盐酸氯哌斯丁

CAS NO

14984-68-0

中文别名

4-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether hydrochloride; 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidinium chloride

英文名称

Piperidine,1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-, hydrochloride (1:1)

英文别名

Piperidine,1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-, hydrochloride (9CI); Piperidine,1-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]-,hydrochloride (6CI,8CI); Cloperastine hydrochloride; HT 11; Hustazol; Nitossil;Novotusil; Seki; p-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether hydrochloride

分子式

C₂₀H₂₄ClNO.ClH

分子量

366.33

EINECS

239-067-8

熔点

147.9°

沸点

84°C 35mm

毒性

急性毒性：小鼠口经LD50：533mg/kg；大鼠LD50： 1986 mg/kg          小鼠腹腔LD50：140g/kg；大鼠LD50： 150 mg/kg          大鼠皮下LD50： 1300mg/kg

中文名称盐酸氯哌斯丁中文同义词盐酸氯哌丁;盐酸氯哌斯汀;盐酸氯哌斯丁;盐酸氯哌丁(咳平);盐酸氯哌斯汀1KG;氯哌斯汀盐酸盐;咳平盐酸盐;CLOPERASTINEHYDROCHLORIDE氯哌斯汀盐酸盐英文名称Cloperastinehydrochloride英文同义词1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL2-[1-PIPERIDYL]-ETHYLETHERHYDROCHLORIDE;CHLOPERASTINEHYDROCHLORIDECAS号14984-68-0分子式C20H25Cl2NO分子量366.32EINECS号239-067-8相关类别医药与生物化工;原料药;分析标准品;法医和兽医标准品;小分子抑制剂;医药原料药;原料;化工原料;医药原料;日用化学品;化学试剂Mol文件14984-68-0.mol结构式盐酸氯哌斯丁性质熔点147.9°储存条件Inertatmosphere,RoomTemperature溶解度可溶于DMSO（少许）、甲醇（少许）颜色白色至类白色Merck14,2395CAS数据库14984-68-0(CASDataBaseReference)盐酸氯哌斯丁用途与合成方法生物活性Cloperastinehydrochloride抑制hERGK+电流，IC50为27nM，这种作用具有浓度依赖性。靶点27nM(K+currents)体外研究CloperastineinhibitsthehERGK+currChemicalbookentsinaconcentrationdependentmannerwithanIC50valueof27nM.Amongtheantitussiveagents,Cloperastine,whichpossessesantitussiveandantiedemicactivity,alsorelaxesthebronchialmusculature.Cloperastineisadrugwithacentralantitussiveeffect,andisalsoendowedwithanantihistaminicandpapaverine-likeactivitysimilartocodeinebutwithoutitsnarcoticeffects.体内研究Intheanesthetizedguineapigs,Cloperastineatatherapeuticdoseof1mg/kgprolongedtheQTintervalandmonophasicactionpotential(MAP)durationwithoutaffectingPRintervalorQRSwidth.Cloperastinehydrochlorideshowsrelativelylowacutetoxicitywhenadministeredbytheintraperitonealrouteinratsandmice,andshowsminortoxicitybytheoralroutewhenadministeredasCloperastinefendizoate,theLD50inratsandmiceforthetwoadministrationroutesexceeds1000and2000mg/kg,respectively.安全信息危险品标志Xn危险类别码22安全说明36WGKGermany3RTECS号TM6491500海关编码2933.39.9200