南京莱昂生物科技有限公司以提供线性多肽和各种修饰性多肽的定制合成服务为主。如2-140aa线性多肽，磷酸化多肽（Phospho-peptide）、磺酸化多肽，生物素标记肽、各种荧光（FITC、FAM 、罗丹明等）标记肽、环肽(Cyclic-peptide)、甲基化多肽(Methyl-peptide)，糖肽，巯基上修饰多肽等。公司还致力于小分子定制合成、基因合成、生物可降解聚合物等生物类产品。公司建立起高效、稳定、高通量的生物化学产品合成平台，为客户提供稳定、高效、诚信的服务。我们相信莱昂生物科技优质的服务、的技术、高质量的产品、具竞争力的价格是您可靠选择。1、 普通线性多肽:链长至150个氨基酸，毫克至公斤级，纯度可达99%。1-10aa多肽，一般1周即可完成。11-40aa多肽一般2周即可完成。40-70aa多肽3周即可完成。（如客户特需加急产品还可以周期更短）。源于公司严格的管理和高效的合成团队，我们粗品一次正确率可达到 98%以上。2、 修饰类：1）N端修饰 ：N端氨基封闭修饰：{Ac},Acetylation，{Br-Ac},Bromoacetyl, {CBZ},Benzyloxycarbonyl {Boc},tertbutoxycarbonyl, {Suc},succiny {Acryl}, acryl, {For}, Formylation {pGlu},{Pyr}, Pyroglutamyl {Mpa},3-Mercaptopropy{Mal},Maleimide,Maleoyl-b-Ala，{Glucose-}葡萄糖。聚乙二醇类修饰：minPEG~PEG5000螯合物类修饰：NOTA DOTA DTPA HYNIC 脂肪酸类修饰：{But}, Butyric acid C4 {Iba}, isobutyric acid C4 {Hex}, Hexanoic acid C6 6-heptenoic acid C6 {Oct}, Octanoic acid C8, {F-Oct}, Perfluoro Octanoic acid F15C8, {Dec}, Decanoic acid C10 , {F-Dec}, Perfluoro Decanoic acid F19C10, {Lau}, Lauric acid C12 , {F-Lau}, Perfluoro Lauric acid F23C12, {Myr}, Myristic acid C14 , {F-Myr}, Perfluoro Myristic acid F27C14 , {Pal}, Palmitic acid C16, {Ste}, Stearic acid C18等其他修饰。2）C端类修饰：{NH2}, Amidation, {-CHO}, {-ol}, {Cya}, Cysteamide {pNA},p-nitroaniline {AMC}, 7-Amino-4-methylcoumarin {AFC} -OMe (C-terminal) -OEt (C-terminal) -OBzl (C-terminal)- OtBu (C-terminal) -NHMe (C-terminal) -NHEt (C-terminal) -TBzl (C-terminal) -NHNH2 (C-terminal) -ED (C-terminal), -NH-CH2CH2-NH2 Azagly Abz 等其他修饰。3）荧光修饰类：FITC (N-Terminal)EDFITC (C temrinus)Lys(FITC) (middle)Lys(FITC) (C temrinus)Lys(FITC) (N terminus)FITC-LC (N-Terminal)5-FAM (N-Terminal)6-FAM (N-Terminal)ED5-FAM (C temrinus)Lys(5-FAM) (middle)Lys(5,6-FAM)Lys(5-FAM) (C temrinus)Lys(5-FAM) (N-Terminus)5-FAM-LC (N-Terminal)Dansyl (N-Terminal)EDDansyl (C temrinus)Lys(Dansyl) (middle)Lys(Dansyl) (C temrinus)Lys(Dansyl) (N-Terminus)Dansyl-LC (N-Terminal)TAMRA (N-Terminal)5(6)-TAMTA-EDTAMRA (C temrinus)Lys(TAMRA) (middle)Lys(TAMRA) (C temrinus)Lys(TAMRA) (N-terminus)TAMRA-LC (N-Terminal)Lys(Dnp) (middle)D-Lys(Dnp) (middle)Dab(Dnp) (middle)Dap(Dnp) (middle)EDDnp (C terminus)MCA (N-Terminal)Lys(MCA) (middle)Lys(MCA) (C temrinus)Lys(MCA) (N-terminus)Rhodamine B- (N-Terminal)Lys(Rhodamine B)Cy3- (N-Terminal)等其他荧光修饰4）非常规氨基酸修饰：{D-Allo-Ile} {Gamma-Glu} {D-Gamma-Glu} {Cys(Cam)} {Cys(Acm)} {Lys(Ac)} {Lys(Dde)} {Tle} {Ser(octanoic acid)}{Ser(Lipoic acid)} {Hyp} {Phg} {D-Phg} {Nva} {D-Nva} {Nle} {D-Nle} {Cit} {D-Cit} {Orn} {D-Orn} {Pen} {D-Pen} {Cha}{D-Cha} {Chg} {D-Chg} {Oic} {Tic} DMTLys(Biotin) (middle) Lys(Biotin) (C temrinus) Lys(LC-Biotin) (middle) Lys(LC-Biotin) (C terminus) Lys(Biotin) (N terminus) Abz Tyr (3-NO2) Glu(EDANS)-NH2 DABCYL Lys(DABCYL) Lys(Abz) {pSer} {pTyr} {pThr}等其他非常规氨基酸。5)偶联修饰：BSA-Peptide N terminusBSA-Peptide C terminusBSA-Peptide CysKLH-Peptide N terminusKLH-Peptide C terminusKLH-Peptide CysOVA-Peptide N terminusOVA-Peptide C terminusOVA-Peptide Cys6）二硫键以及酰胺环类修饰：Mono Disulfide bridgeDouble Disulfide bridgeTriple Disulfide bridgeRandom Triple Disulfide bridgeSame Seq. Inter-Disulfide bridgeDifferent Inter-Disulfide bridgeAmide cyclic (end)Amide cyclic (Side chain)Orn side chain Amide cyclic以上仅为部分修饰