乙二醇单甲醚,109-86-4，生产厂家，价格-洛克化工网移动版

返回



基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

上游产品

下游产品

表征图谱

乙二醇单甲醚

中文名称：: 乙二醇单甲醚

中文别名：: 乙二醇甲醚;
2-甲氧基乙醇;
乙二醇一甲醚;
乙二醇单甲醚;
乙二醇独甲醚;
羟乙基·甲基醚;
甲氧基乙醇

英文名称：: Ethanol, 2-methoxy-

英文别名：: 2-methoxyethanol;
Ethylene glycol monomethyl ether,Methyl glycol;
ethylene glycol monomethyl ether;
H2O;
dowanol7;
glycol monomethyl ether;
Egme;
Ethylene Glycol Monomethyl Ether;
2-Methoxy-aethanol;
SOLVENT S;
WATER G;
MECS;
Ethylene glycol monomethyl ether;
Methyl Cellosolve;
O-Methyl Glycol;
2-Methoxyethanol;
1-hydroxy-2-methoxy-ethane;
EGM;
TAP-WATER;
2-methoxy-ethanol;
Prist;
monoethylene glycol methyl ether;
2-hydroxyethyl methyl ether

CAS No.：: 109-86-4

分子式：: C₃H₈O₂

分子量：: 76.09

精确分子量：: 76.05240

PSA：: 29.46000

MDL：: MFCD00002867

EINECS：: 203-713-7

BRN：: 1731074

InChI：: InChI=1/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H33

危险品标志：: T:Toxic

风险术语：: R10; R20/21/22; R60;

安全术语：: S45; S53;

分子结构式：

SDS：: 查看

乙二醇单甲醚制备方法及用途

制备方法

1.由环氧乙烷与甲醇反应而得。将甲醇加入三氟化硼乙醚络合物中，在搅拌下于25-30℃通入环氧乙烷，通完后温度自动升至38-45℃，将所得反应液用氢氰化钾-甲醇溶液中和至pH=8-9。回收甲醇，蒸馏，收集130℃以前的馏分即得粗品。再进行分馏，收集123-125℃馏分即为成品。工业生产中，将环氧乙烷与无水甲醇在高温高压下反应，不需催化剂，可得高收率的产品。 2.其制备方法是将甲醇加入三氟化硼乙醚配合物中，在搅拌下于25～300℃通入环氧乙烷，通完后温度自动升到38～45℃，所得反应液用氢氧化钾甲醇溶液中和到pH=8～9，回收甲醇，蒸馏，再经分馏得产品。精制方法：易含杂质有水、二甘醇一甲醚(甲基卡必醇)和微量的酸、醛等。实验室的精制方法是用无水碳酸钠干燥后分馏。若有过氧化物存在，可加氯化亚锡回流或将其通过活性氧化铝柱除去。脂肪族酮可加2,4-二硝基苯肼除去。也可用碳酸钾、硫酸钙、硫酸镁或硅胶作干燥剂。3.将含量95%的三级纯乙二醇单甲醚与无水碳酸钠一起振荡，除去无机酸或有机酸杂质，再用无水硫酸钙干燥后蒸馏。

合成制备方法

1.由环氧乙烷与甲醇反应而得。将甲醇加入三氟化硼乙醚络合物中，在搅拌下于25-30℃通入环氧乙烷，通完后温度自动升至38-45℃，将所得反应液用氢氰化钾-甲醇溶液中和至pH=8-9。回收甲醇，蒸馏，收集130℃以前的馏分即得粗品。再进行分馏，收集123-125℃馏分即为成品。

工业生产中，将环氧乙烷与无水甲醇在高温高压下反应，不需催化剂，可得高收率的产品。

2.其制备方法是将甲醇加入三氟化硼乙醚配合物中，在搅拌下于25～300℃通入环氧乙烷，通完后温度自动升到38～45℃，所得反应液用氢氧化钾甲醇溶液中和到pH=8～9，回收甲醇，蒸馏，再经分馏得产品。

精制方法：易含杂质有水、二甘醇一甲醚(甲基卡必醇)和微量的酸、醛等。实验室的精制方法是用无水碳酸钠干燥后分馏。若有过氧化物存在，可加氯化亚锡回流或将其通过活性氧化铝柱除去。脂肪族酮可加2,4-二硝基苯肼除去。也可用碳酸钾、硫酸钙、硫酸镁或硅胶作干燥剂。

3.将含量95%的三级纯乙二醇单甲醚与无水碳酸钠一起振荡，除去无机酸或有机酸杂质，再用无水硫酸钙干燥后蒸馏。

用途简介

用作涂料溶剂、渗透剂、匀染剂及有机合成中间体，也用作喷气燃料的添加剂。

用途

1.本品主要用作油脂、硝化纤维素、合成树脂、醇溶性染料和乙基纤维素的溶剂；涂料工业用作清漆快干剂和涂层稀释剂；印染工业用作渗透剂和匀染剂；燃料工业用作添加剂；纺织工业用于染色助剂以及可作为有机合成中间体。二乙二醇单甲醚主要用作油墨、染料、树脂、纤维素及涂料的高沸点溶剂，加入涂料中能使之易于流动、涂刷和流平，可用作烃的萃取剂，有机合成工业中用于制备酯类衍生物的中间体，以及分析化学中用作化学试剂等。多乙二醇单甲醚可用作刹车液等。

2.用作醇中可溶的染料、油墨、可的松等的溶剂和农药分散剂、皮革处理剂、增塑剂等。

3.广泛用作硝基纤维漆、清漆、瓷漆等涂料的溶剂和稀释剂；胶黏剂的非活性稀释剂；各种油脂类、木质素、硝基纤维素、乙酸纤维素、醇溶性染料、油墨和合成树脂的溶剂以及农药的分散剂、皮革处理剂、增塑剂、光亮剂和有机合成中间体等。

4.用作溶剂。^[30]

乙二醇单甲醚物化性质

外观与性状：: 无色透明液体
密度：: 998.203±0.01 kg/m3 at 20 °C
熔点：: -85 °C
沸点：: 124-125 °C(lit.)
闪点：: 115 °F
水溶解性：: SOLUBLE
折射率：: n20/D 1.402(lit.)
蒸汽压：: 0.204mmHg at 25°C
蒸汽密度：: 2.62 (vs air)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂分开存放
稳定性相关：: 1.具有醇和醚的化学性质，可与邻苯二甲酸、蓖麻酸、油酸等生成酯。
2.稳定性^[25] 稳定
3.禁配物^[26] 酰基氯、酸酐、强氧化剂
4.避免接触的条件^[27] 空气、光照
5.聚合危害^[28] 不聚合
其它信息：: 1.性状：无色液体，略有醚的气味。^[1]
2.熔点（℃）：-85.1^[2]
3.沸点（℃）：124.5^[3]
4.相对密度（水=1）：0.97（20℃）^[4]
5.相对蒸气密度（空气=1）：2.62^[5]
6.饱和蒸气压（kPa）：1.29（25℃）^[6]
7.燃烧热（kJ/mol）：-399.5^[7]
8.临界温度（℃）：324.45^[8]
9.临界压力（MPa）：5.285^[9]
10.辛醇/水分配系数：-0.77^[10]
11.闪点（℃）：39^[11]
12.引燃温度（℃）：285^[12]
13.爆炸上限（%）：14^[13]
14.爆炸下限（%）：1.8^[14]
15.溶解性：与水混溶，可混溶于醇类、酮类、烃类。^[15]
16.折射率（n20ºC）：1.4028
17.折射率（n25ºC）：1.4013
18.黏度（mPa·s,20ºC）：1.72
19.黏度（mPa·s,25ºC）：1.60
20.闪点（ºC,闭口）：43
21.闪点（ºC,开口）：461
22.比热容（KJ/(kg·K),25ºC,定压）：2.20
23.电导率（S/m,20ºC）：1.09×10^-6
24.蒸气压（kPa,25ºC）：1.3
25.蒸气压（kPa,27ºC）：1.3
26.蒸气压（kPa,56ºC）：6.7
27.体膨胀系数（K^-1,20ºC）：0.00095
28.临界密度（g·cm^-3）：0.281
29.临界体积（cm³·mol^-1）：263
30.临界压缩因子：0.280
31.偏心因子：0.731
32.溶度参数(J·cm^-3)^0.5：23.204
33.van der Waals面积（cm²·mol^-1）：6.880×10⁹
34.van der Waals体积（cm³·mol^-1）：45.870

乙二醇单甲醚毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL5775000

CHEMICAL NAME :: Ethanol, 2-methoxy-

CAS REGISTRY NUMBER :: 109-86-4

BEILSTEIN REFERENCE NO. :: 1731074

LAST UPDATED :: 199801

DATA ITEMS CITED :: 117

MOLECULAR FORMULA :: C3-H8-O2

MOLECULAR WEIGHT :: 76.11

WISWESSER LINE NOTATION :: Q2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 3380 mg/kg

TOXIC EFFECTS :: Gastrointestinal - gastritis Liver - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 25 ppm

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2370 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2068 mg/kg

TOXIC EFFECTS :: Blood - other hemolysis with or without anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Cardiac - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 ppm/7H

TOXIC EFFECTS :: Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2147 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 890 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Blood - other hemolysis with or without anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 ppm/6H/2W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10206 mg/kg/21D-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg/10D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Immunological Including Allergic - decreased immune response

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 ppm/6H/13W-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 970 mg/m3/7H/5W-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Blood - changes in spleen

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/6H/11D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 gm/kg/4W-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg/16D-I

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29484 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg/4D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Immunological Including Allergic - decrease in humoral immune response

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12110 mg/kg/2W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/13W-C

TOXIC EFFECTS :: Endocrine - effect on menstrual cycle Endocrine - other changes Blood - changes in spleen

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 ppm/6H/11D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 750 ppm/7H/12W-I

TOXIC EFFECTS :: Blood - microcytosis with or without anemia Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 ppm/6H/13W-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 65 gm/kg/13W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 175 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 175 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15015 mg/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 350 mg/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 68 mg/kg/4H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 30 ppm/6H

SEX/DURATION :: male 65 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ppm/6H

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ppm/6H

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 30 ppm/6H

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 11592 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 4375 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 2 gm/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 1 gm/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - gastrointestinal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 330 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 190 mg/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 190 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 190 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 440 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 175 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 500 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6250 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/6H

SEX/DURATION :: male 11 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 50 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 50 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1200 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3200 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 250 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 250 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 930 mg/kg

SEX/DURATION :: female 20-45 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 633 mg/kg

SEX/DURATION :: female 20-45 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 300 ppm/6H

SEX/DURATION :: male 65 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 50 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 50 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6250 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 65 gm/kg

SEX/DURATION :: male 65 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1562 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,390,1984 *** REVIEWS *** ACGIH TLV-TWA 16 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 25 ppm (80 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,158,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (80 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (80 mg/m3);STEL 40 ppm (120 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (15 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (80 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (16 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (15 mg/m3);STEL 10 ppm (30 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 25 ppm (80 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (16 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENEGLYCOL MONOMETHYL ETHER-air:10H TWA 0.1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46240 No. of Facilities: 11165 (estimated) No. of Industries: 128 No. of Occupations: 102 No. of Employees: 103424 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46240 No. of Facilities: 8042 (estimated) No. of Industries: 89 No. of Occupations: 86 No. of Employees: 168180 (estimated) No. of Female Employees: 53403 (estimated)

毒理学数据：

1.急性毒性^[16]

LD50：2370mg/kg（大鼠经口）；2000mg/kg（兔经皮）

LC50：1500ppm（7h）（大鼠吸入）

2.刺激性^[17]

家兔经皮：483mg（24h），轻度刺激。

家兔经眼：500mg（24h），轻度刺激。

3.亚急性与慢性毒性^[18] 家兔经口，0.1ml/（kg·d），7d，见暂时性血尿。加大剂量，可致衰竭、震颤、蛋白尿和血尿。尸检见严重肾损害。大鼠暴露于1.05g/m³，每天7h，每周5d，1月后见血液中幼稚白细胞增加。

4.致突变性^[19] 显性致死试验：大鼠经口500mg/kg。精子形态学：大鼠经口500mg/kg

5.致畸性^[20] 大、小鼠孕后不同时间或多代通过皮下、经口、吸入不同途径给予不同剂量，可致心血管系统、颅面部（包括鼻、舌）、胃肠系统、肌肉骨骼系统、中枢神经系统、泌尿生殖系统、肝胆管系统发育畸形。

6.其他^[21] 大鼠经口最低中毒剂量（TDLo）：175mg/kg（孕7~13d），致心血管（循环）系统发育异常。小鼠经口最低中毒剂量（TDLo）：250mg/kg（1d，雄性），影响精子生成（包括遗传物质、精子形态、活动力、计数）

生态数据：

1.生态毒性^[22]

LC50：＞10000mg/L（96h）（蓝鳃太阳鱼）；15520mg/L（96h）（虹鳟鱼，一年生）

2.生物降解性^[23]

好氧生物降解性（h）：168~672

厌氧生物降解性（h）：672~2688

3.非生物降解性^[24]

水中光氧化半衰期（h）：7400~4.70×10⁵

空气中光氧化半衰期（h）：5.7~57

乙二醇单甲醚

乙二醇单甲醚制备方法及用途

制备方法

合成制备方法

用途简介

用途

乙二醇单甲醚物化性质

乙二醇单甲醚安全信息

乙二醇单甲醚毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

乙二醇单甲醚 MSDS

乙二醇单甲醚分子结构与计算化学数据

分子结构数据

计算化学数据

乙二醇单甲醚上游产品

乙二醇单甲醚下游产品

乙二醇单甲醚表征图谱

推荐供应商

乙二醇单甲醚

乙二醇单甲醚 制备方法及用途

制备方法

合成制备方法

用途简介

用途

乙二醇单甲醚 物化性质

乙二醇单甲醚 安全信息

乙二醇单甲醚 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

乙二醇单甲醚 MSDS

乙二醇单甲醚 分子结构与计算化学数据

分子结构数据

计算化学数据

乙二醇单甲醚 上游产品

乙二醇单甲醚 下游产品

乙二醇单甲醚 表征图谱

推荐供应商

乙二醇单甲醚制备方法及用途

乙二醇单甲醚物化性质

乙二醇单甲醚安全信息

乙二醇单甲醚毒理性

乙二醇单甲醚分子结构与计算化学数据

乙二醇单甲醚上游产品

乙二醇单甲醚下游产品

乙二醇单甲醚表征图谱