一缩二乙二醇
- 中文名称：
- 一缩二乙二醇
- 中文别名：
- 二乙二醇;
二甘醇;
二(羟乙基)醚;
2,2'-氧代二乙醇
- 英文名称：
- diethylene glycol
- 英文别名：
- Diethylene glycol;
DEG;
2,2'-Oxydiethanol;
Bis(2-hydroxyethyl)ether
- CAS No.：
- 111-46-6
- 分 子 式：
- C4H10O3
- 分 子 量：
- 106.12
- 精确分子量：
- 106.06300
- PSA：
- 49.69000
- MDL：
- MFCD00002882
- EINECS：
- 203-872-2
- BRN：
- 969209
- InChI：
- InChI:1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H23
- 危险品标志：
Xn
Xn- 风险术语：
- R22;
- 安全术语：
- S46;
- 分子结构式：
-
- SDS：
- 查看
一缩二乙二醇 制备方法及用途
制备方法
-
1.一缩二乙二醇是环氧乙烷制乙醇时的副产品。工艺流程：用直接水合法将环氧乙烷与水按1：8混合送入混合反应器，在150℃MPa下，反应40-60min,生成脱水塔进一步脱水；塔底的乙二醇混合液送入乙二醇塔，塔顶可得99.8%以上的乙二醇。塔底液送入一缩精馏塔，在塔顶温度135-140℃,压力4.0KPa下，从塔顶得到一缩二乙二醇。继续分离，可得二缩三乙二醇、三缩四乙二醇。精制方法：所含杂质有水、乙二醇、三甘醇等。可用减压蒸馏后分步结晶的方法精制。取二甘醇1650mL进行减压分馏，弃去480mL初馏分，收集1000mL中间馏分进行分步结晶，可得700mL二甘醇。2. 与酸酐作用时生成酯，与烷基硫酸酯或卤代烃作用生成醚。3. 合成：由环氧乙烷与乙二醇作用而制得。也是环氧乙烷水合制乙二醇时的副产品。
合成制备方法
1.一缩二乙二醇是环氧乙烷制乙醇时的副产品。
用途简介
-
用作气体脱水剂和芳烃抽提溶剂，也用作纺织品的润滑剂、软化剂和整理剂，以及增塑剂、增湿剂、上浆剂、硝基纤维素、树脂和油脂等溶剂。
用途
1.主要用作气体脱水剂和芳烃萃取溶剂。也用作硝酸纤维素、树脂、油脂、印刷油墨等的溶剂，纺织品的软化剂、整理剂，以及从煤焦油中萃取香豆酮和茚等。此外，二甘醇还用作刹车油配合剂、赛璐珞柔软剂、防冻剂和乳液聚合时的稀释剂等。还用于橡胶及树脂增塑剂；聚酯树脂；纤维玻璃；氨基甲酸酯泡沫；润滑油粘度改进剂等产品的生产。用作合成不饱和聚酯树脂等。
2.用作合成不饱和聚酯树脂、增塑剂等。还用于防冻剂、气体脱水剂、增塑剂、溶剂、芳烃抽提剂、卷烟吸湿剂、纺织品润滑剂及整理剂、糨糊及各种胶的防干剂、还原染料吸湿助溶剂等。是油脂、树脂、硝化纤维素等的常用溶剂。
一缩二乙二醇 物化性质
- 外观与性状：
- 透明液体
- 密度：
- 1.118 g/mL at 25 °C(lit.)
- 熔点：
- −10 °C(lit.)
- 沸点：
- 245 °C(lit.)
- 闪点：
- 143 °C
- 水溶解性：
- SOLUBLE
- 折射率：
- n20/D 1.447(lit.)
- 蒸汽压：
- 0.00469mmHg at 25°C
- 蒸汽密度：
- 2.14 (vs air)
- 存储条件/存储方法：
1.密封于阴凉、干燥处保存。确保工作间有良好的通风设施。
2.远离火源、水源。储存的地方远离氧化剂。
- 稳定性相关：
- 1. 避免与氧化物、潮湿的水分接触。
- 其它信息：
1. 性状：
2. 沸点（ºC,101.3kPa）：245
3. 熔点（ºC）：-10.5
4. 相对密度（g/mL,20/4ºC）：1.118
5. 相对蒸汽密度（g/mL,空气=1）：2.14
6. 折射率（15ºC）：1.4490
7. 折射率（20ºC）：1.4472
8. 常温折射率（n25）：1.446
9. 黏度（mPa·s,20ºC）：35.7
10. 黏度（mPa·s,25ºC）：30
11. 闪点（ºC,闭口）：143
12. 燃点（ºC）：229
13. 蒸发热（KJ/mol,b.p.）：52.297
14. 燃烧热（KJ/mol）：2380.2
15. 比热容（KJ/(kg·K),20ºC,定压）：2.31
16. 电导率（S/m,20ºC）：5.86×10-7
17. 蒸气压（kPa,20ºC）：<0.0013
18. 体膨胀系数（K-1,20ºC）：0.000635
19. 爆炸下限（%,V/V）：0.7
20. 爆炸上限（%,V/V）：22
21. 溶解性：能与水、乙醇、乙二醇、丙酮、氯仿、糠醛等混溶。与乙醚、四氯化碳、二硫化碳、直链脂肪烃、芳香烃等不混溶。
22. 相对密度（25℃，4℃）：1.1122
23. 临界温度（ºC）：476.85
24. 临界压力（MPa）：4.7
25. 溶度参数(J·cm-3)0.5：27.775
26. vanderWaals面积（cm2·mol-1）：8.920×109
27. vanderWaals体积（cm3·mol-1）：60.700
28. 气相标准燃烧热(焓)(kJ·mol-1)：-2432.0
29. 气相标准声称热(焓)(kJ·mol-1)：-571.2
30. 液相标准燃烧热(焓)(kJ·mol-1)：-2374.7
31. 液相标准声称热(焓)(kJ·mol-1)：-628.5
32. 液相标准热熔(J·mol-1·K-1)：258.4
一缩二乙二醇 安全信息
- 海关代码：
- 2909410000
- WGK_Germany：
- 1
德国有关水污染物质的分类清单 - 危险类别码：
- R22
- 安全说明：
- S46
- RTECS号：
- ID5950000
- 安全标志：
- S46:万一发生不慎吞咽，立刻寻求医生的建议（展示产品容器或者标签）。
S36:穿戴合适的防护服装。 - 危险标志：
- Xn:Harmful
一缩二乙二醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ID5950000
- CHEMICAL NAME :
- Diethylene glycol
- CAS REGISTRY NUMBER :
- 111-46-6
- BEILSTEIN REFERENCE NO. :
- 0969209
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 56
- MOLECULAR FORMULA :
- C4-H10-O3
- MOLECULAR WEIGHT :
- 106.14
- WISWESSER LINE NOTATION :
- Q2O2Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Human
- REFERENCE :
- 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,731,1969
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Liver - other changes Nutritional and Gross Metabolic - metabolic acidosis
- REFERENCE :
- JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 109,731,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12565 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,3836,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6565 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7826 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15650 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 23700 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/m3/2H
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - excitement Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9719 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in spleen
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 6,342,1947
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 42,355,1931
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13300 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 9 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 67,101,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 3300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,173,1939
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 11890 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,25,1974
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2236 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 4472 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,93,1937
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2688 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 7800 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - muscle weakness Liver - other changes
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,142,1945
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 14 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Gastrointestinal - nausea or vomiting
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(3),16,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 297 gm/kg/99D-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Related to Chronic Data - death
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/m3/2H/26W-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - emphysema Related to Chronic Data - death
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/m3/11W-I
- TOXIC EFFECTS :
- Cardiac - other changes Liver - fatty liver degeneration Related to Chronic Data - death
- REFERENCE :
- GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(12),30,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 105 gm/kg/18D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,261,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 17300 uL/kg/30D-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 29,325,1947 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 890 gm/kg/53W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - changes in both tubules and glomeruli
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,40,1946
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg/82W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Blood - tumors
- REFERENCE :
- VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 420 mg/kg/22W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Blood - tumors
- REFERENCE :
- VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 mg/m3/2H/30W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Skin and Appendages - tumors
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(2),36,1968
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 mg/kg/66W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Blood - tumors
- REFERENCE :
- VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1752 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
- REFERENCE :
- IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5. Volume(issue)/page/year: 36,55,1967
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 584 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
- REFERENCE :
- FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 4,149,1945
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 840 mg/kg/81W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Blood - tumors
- REFERENCE :
- VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #6801-83 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 gm/kg
- SEX/DURATION :
- female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 27,801,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 76420 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 38212 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0291-1175
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 343 gm/kg
- SEX/DURATION :
- multigeneration
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Newborn - sex ratio
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 343 gm/kg
- SEX/DURATION :
- multigeneration
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - other postnatal measures or effects
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 14,622,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 50 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 100 gm/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-159327 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 23 ppm (100 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 25544 No. of Facilities: 27975 (estimated) No. of Industries: 222 No. of Occupations: 129 No. of Employees: 273598 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 25544 No. of Facilities: 55518 (estimated) No. of Industries: 292 No. of Occupations: 178 No. of Employees: 890145 (estimated) No. of Female Employees: 261558 (estimated)
- 毒理学数据：
1、刺激性：兔子经皮：500mg 轻度刺激。
兔子经眼：50mg 轻度刺激。
2、急性毒性：大鼠经口LD50：12565mg/kg；兔子经皮LD50：11890mg/kg
3、属微毒类。可经皮吸收，对皮肤黏膜刺激小。与乙二醇相似对中枢神经系统有抑制作用。能引起肾脏病理改变及尿路结石。人一次口服致死量估计为1mL/kg。服用二甘醇后约24小时出现恶心、呕吐、腹痛、腹泻等肠胃道症状。致死者随之出现头痛、肾区疼痛、一时性多尿然后少尿、嗜睡、面部轻度浮肿等。无尿发生后2～7日内昏迷而死。故本品应禁作药用，避免长期与皮肤接触。
- 生态数据：
对水体有轻微的危害。
一缩二乙二醇 MSDS
| 第一部分：化学品名称 |
| 化学品中文名称： | 二乙二醇；二甘醇 |
| 化学品英文名称： | Diethylene glycol；Diglycol |
| 中文俗名或商品名： | |
| Synonyms： | |
| CAS No.： | 111-46-6 |
| 分子式： | C4H10O3 |
| 分子量： | 106.12 |
| 第二部分：成分/组成信息 |
| 纯化学品 混合物 | |||
| 化学品名称：二乙二醇；二甘醇 | |||
|
| 第三部分：危险性概述 |
| 危险性类别： | |
| 侵入途径： | 吸入 食入 经皮吸收 |
| 健康危害： | 未见本品引起职业中毒的报道。口服引起恶心、呕吐、腹痛、腹泻及肝、肾损害。可因严重肾损害而致死。 |
| 环境危害： | |
| 燃爆危险： | 本品可燃。 |
| 第四部分：急救措施 |
| 皮肤接触： | 脱去污染的衣着，用大量流动清水彻底冲洗。 |
| 眼睛接触： | 立即翻开上下眼睑，用流动清水或生理盐水冲洗。 |
| 吸入： | 脱离现场至空气新鲜处。就医。 |
| 食入： | 给饮足量温水，催吐，就医。 |
| 第五部分：消防措施 |
| 危险特性： | 遇高热、明火或与氧化剂接触，有引起燃烧的危险。 |
| 有害燃烧产物： | 一氧化碳、二氧化碳。 |
| 灭火方法及灭火剂： | 尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。用水喷射逸出液体，使其稀释成不燃性混合物，并用雾状水保护消防人员。灭火剂：水、雾状水、抗溶性泡沫、干粉、二氧化碳、砂土。 |
| 消防员的个体防护： | |
| 禁止使用的灭火剂： | |
| 闪点(℃)： | 124 |
| 自燃温度(℃)： | 引燃温度(℃)：228 |
| 爆炸下限[%(V/V)]： | 无资料 |
| 爆炸上限[%(V/V)]： | 无资料 |
| 最小点火能(mJ)： | |
| 爆燃点： | |
| 爆速： | |
| 最大燃爆压力(MPa)： | |
| 建规火险分级： |
| 第六部分：泄漏应急处理 |
| 应急处理： | 迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自吸过滤式防毒面具（全面罩），穿防毒服。尽可能切断泄漏源。防止流入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。也可以用大量水冲洗，洗水稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。 |
| 第七部分：操作处置与储存 |
| 操作注意事项： | 密闭操作，注意通风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴防化学品手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类接触。搬运时轻装轻卸，防止包装破损。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 |
| 储存注意事项： | 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、酸类分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。 |
| 第八部分：接触控制/个体防护 |
| 最高容许浓度： | 中 国 MAC：未制订标准前苏联MAC：10mg／m3 美国TLV—TWA：未制订标准 |
| 监测方法： | |
| 工程控制： | 密闭操作，注意通风。 |
| 呼吸系统防护： | 空气中浓度超标时，应该佩戴防毒面具。 |
| 眼睛防护： | 必要时戴安全防护眼镜。 |
| 身体防护： | 穿工作服。 |
| 手防护： | 戴防化学品手套。 |
| 其他防护： | 工作现场严禁吸烟。避免长期反复接触。定期体检。保持良好的卫生习惯。 |
| 第九部分：理化特性 |
| 外观与性状： | 无色、无臭、开始味甜回味苦的粘稠液体，具有吸湿性。 |
| pH： | |
| 熔点(℃)： | -8．0 |
| 沸点(℃)： | 245．8 |
| 相对密度(水=1)： | 1．12(20℃) |
| 相对蒸气密度(空气=1)： | 3．66 |
| 饱和蒸气压(kPa)： | 0．13(91．8℃) |
| 燃烧热(kJ/mol)： | |
| 临界温度(℃)： | |
| 临界压力(MPa)： | |
| 辛醇/水分配系数的对数值： | |
| 闪点(℃)： | 124 |
| 引燃温度(℃)： | 引燃温度(℃)：228 |
| 爆炸上限%(V/V)： | 无资料 |
| 爆炸下限%(V/V)： | 无资料 |
| 分子式： | C4H10O3 |
| 分子量： | 106.12 |
| 蒸发速率： | |
| 粘性： | |
| 溶解性： | 与水混溶，不溶于苯、甲苯、四氯化碳。 |
| 主要用途： | 用作人造丝的软化剂和烟草的湿润剂，还是某些化工产品的中间体，也用作汽车发动机防冻剂、刹车油等。 |
| 第十部分：稳定性和反应活性 |
| 稳定性： | 在常温常压下 稳定 |
| 禁配物： | 强氧化剂、强酸。 |
| 避免接触的条件： | |
| 聚合危害： | 不能出现 |
| 分解产物： | 一氧化碳、二氧化碳。 |
| 第十一部分：毒理学资料 |
| 急性毒性： | LD50：16600mg／kg(大鼠经口)；26500mg／kg(小鼠经口) LC50： |
| 急性中毒： | |
| 慢性中毒： | |
| 亚急性和慢性毒性： | |
| 刺激性： | |
| 致敏性： | |
| 致突变性： | |
| 致畸性： | |
| 致癌性： |
| 第十二部分：生态学资料 |
| 生态毒理毒性： | |
| 生物降解性： | |
| 非生物降解性： | |
| 生物富集或生物积累性： |
| 第十三部分：废弃处置 |
| 废弃物性质： | |
| 废弃处置方法： | 处置前应参阅国家和地方有关法规。建议用焚烧法处置。 |
| 废弃注意事项： |
| 第十四部分：运输信息 |
|
|
| 危险货物编号： | |
| UN编号： | |
| 包装标志： | |
| 包装类别： | |
| 包装方法： | |
| 运输注意事项： | 运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与氧化剂、酸类等混装混运。船运时，应与机舱、电源、火源等部位隔离。公路运输时要按规定路线行驶。 |
| RETCS号： | |
| IMDG规则页码： |
| 第十五部分：法规信息 |
| 国内化学品安全管理法规： | |
| 国际化学品安全管理法规： |
| 第十六部分：其他信息 |
| 参考文献： | 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 |
| 填表时间： | 年月日 |
| 填表部门： | |
| 数据审核单位： | |
| 修改说明： | |
| 其他信息： | 3 |
| MSDS修改日期： | 年月日 |
一缩二乙二醇 海关数据
中国海关编码：2909410000
- 概述：
- 2909410000 2,2'-氧联二乙醇(二甘醇)。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.5%。普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途
- 摘要/Summary：
- 2909410000 2,2'-oxydiethanol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%
一缩二乙二醇 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：25.39
2、 摩尔体积（cm3/mol）：95.9
3、 等张比容（90.2K）：244.4
4、 表面张力（dyne/cm）：42.1
5、 极化率（10-24cm3）：10.06
计算化学数据
1.疏水参数计算参考值（XlogP）:-1.3
2.氢键供体数量:2
3.氢键受体数量:3
4.可旋转化学键数量:4
5.互变异构体数量:无
6.拓扑分子极性表面积49.7
7.重原子数量:7
8.表面电荷:0
9.复杂度:26.1
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
一缩二乙二醇 上游产品
推荐供应商
湖北诺纳科技有限公司
二乙二醇
- 联系人：张经理
- 电 话：027-59209883
- 手 机：17386169806
- Cas号：111-46-6
- 包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
- 纯度：99%
- 价格：1.0元 - 25.0元
沧州恩科医药科技有限公司
二乙二醇/二甘醇
- 联系人：赵经理
- 电 话：0317-5106598
- 手 机：13323075105
- Cas号：111-46-6
- 包装：100kg,200kg,300kg,400kg,500kg
- 纯度：98%
- 价格：64.0元 - 100.0元
湖北云镁科技有限公司
二乙二醇
- 联系人：方经理
- 电 话：027-59206672
- 手 机：18327059871
- Cas号：111-46-6
- 包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
- 纯度：99%
- 价格：1.0元 - 25.0元
上海吉至生化科技有限公司
二乙二醇
- 联系人：Shirley张
- 电 话：021-57520831
- 手 机：18116052675
- Cas号：111-46-6
- 包装：100gea,25gea,500gea,500mlea
- 纯度：99%
- 价格：24.0元 - 78.0元