乙酸丁酯,123-86-4，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

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乙酸丁酯

中文名称：: 乙酸丁酯

中文别名：: 乙酸丁酯;
丁基醋酸;
乙酸正丁酯;
醋酸正丁酯

英文名称：: butyl acetate

英文别名：: butyl acetate;
Butyl Acetate;
Butyl ethanoate;
butanol acetate;
acetic acid n-butyl ester;
Butyl acetate;
Butylacetat;
Acetate de butyle;
n-Butyl ethanoate;
Acetic Acid Butyl Ester;
N-BUTYL ACETATE;
Acetic acid,butyl ester

CAS No.：: 123-86-4

分子式：: C₆H₁₂O₂

分子量：: 116.16

精确分子量：: 116.08400

PSA：: 26.30000

MDL：: MFCD00009445

EINECS：: 204-658-1

BRN：: 1741921

InChI：: InChI=1/C6H12O2/c1-3-4-5-8-6(2)7/h3-5H2,1-2H33

危险品标志：

风险术语：: R10;R66;R67

安全术语：: S25

分子结构式：

SDS：: 查看

乙酸丁酯制备方法及用途

制备方法

1.由乙酸与正丁醇在硫酸存在下酯化而得。将丁醇、乙酸和硫酸按比例投入酯化釜,在120℃进行酯化,经回流脱水,控制酯化时的酸值在0.5以下,所得粗酯经中和后进入蒸馏釜,经蒸馏、冷凝、分离进行回流脱水,回收醇酯,最后在126℃以下蒸馏而得产品。生产工艺有连续法及间歇法,视生产规模不同而定。原料消耗定额:乙酸(98%)540kg/t、正丁醇650kg/t。近年来,开发应用固体酸、杂多酸等代替硫酸催化剂,以减轻设备腐蚀的科研报导日见增多,但尚未见成功用于工业生产的报道。 2.由乙酸与正丁醇在硫酸存在下酯化而得。精制方法:一般含有游离的乙酸和丁醇。若原料是由发酵法制得者尚含有少量的乙酸异丁酯、异丁醇、乙酸戊酯、乙酸己酯等。精制时用碳酸氢钠或碳酸钠饱和溶液洗涤,再用氯化钠饱和溶液洗涤,经无水碳酸钾、硫酸钠或硫酸镁干燥后精馏。残存的水和醇与酯形成共沸混合物变成初馏分除去。其他的精制方法有先蒸馏,再分批加入少量高锰酸钾回流,直到高锰酸钾的紫色不消失为止,无水硫酸钙干燥、过滤、再精馏。 3.将工业乙酸丁酯进行精馏、超净过滤、超净分装即可。 4.制法: 于装有回流冷凝器的反应瓶中,加入98%的甲酸61g(1.33mol),无水乙醇(2)31g(0.67mol),一粒沸石,加热回流反应24h。改为蒸馏装置进行蒸馏,收集62℃以下的馏分,溜出液用氯化钠饱和,再依次用饱和碳酸氢钠、饱和氯化钠溶液洗涤。无水硫酸钠干燥,分馏,收集53～54℃的馏分,得甲酸丁酯(1)36g,收率72%。

合成制备方法

1.由乙酸与正丁醇在硫酸存在下酯化而得。将丁醇、乙酸和硫酸按比例投入酯化釜，在120℃进行酯化，经回流脱水，控制酯化时的酸值在0.5以下，所得粗酯经中和后进入蒸馏釜，经蒸馏、冷凝、分离进行回流脱水，回收醇酯，最后在126℃以下蒸馏而得产品。生产工艺有连续法及间歇法，视生产规模不同而定。原料消耗定额：乙酸（98%）540kg/t、正丁醇650kg/t。近年来，开发应用固体酸、杂多酸等代替硫酸催化剂，以减轻设备腐蚀的科研报导日见增多，但尚未见成功用于工业生产的报道。

2.由乙酸与正丁醇在硫酸存在下酯化而得。精制方法：一般含有游离的乙酸和丁醇。若原料是由发酵法制得者尚含有少量的乙酸异丁酯、异丁醇、乙酸戊酯、乙酸己酯等。精制时用碳酸氢钠或碳酸钠饱和溶液洗涤，再用氯化钠饱和溶液洗涤，经无水碳酸钾、硫酸钠或硫酸镁干燥后精馏。残存的水和醇与酯形成共沸混合物变成初馏分除去。其他的精制方法有先蒸馏，再分批加入少量高锰酸钾回流，直到高锰酸钾的紫色不消失为止，无水硫酸钙干燥、过滤、再精馏。

3.将工业乙酸丁酯进行精馏、超净过滤、超净分装即可。

4.制法：

于装有回流冷凝器的反应瓶中，加入98%的甲酸61g（1.33mol），无水乙醇（2）31g（0.67mol），一粒沸石，加热回流反应24h。改为蒸馏装置进行蒸馏，收集62℃以下的馏分，溜出液用氯化钠饱和，再依次用饱和碳酸氢钠、饱和氯化钠溶液洗涤。无水硫酸钠干燥，分馏，收集53～54℃的馏分，得甲酸丁酯（1）36g，收率72%。^[26]

用途简介

醋酸丁酯又称乙酸丁酯，是一种无色、易燃、具有水果香味的液体。有毒，对眼及上呼吸道均有强烈的刺激作用，有麻醉作用。

用途

1.优良的有机溶剂，对醋酸丁酸纤维素、乙基纤维素、氯化橡胶、聚苯乙烯、甲基丙烯酸树脂以及许多天然树脂如栲胶、马尼拉胶、达玛树脂等均有良好的溶解性能。广泛应用于硝化纤维清漆中，在人造革、织物及塑料加工过程中用作溶剂，在各种石油加工和制药过程中用作萃取剂，也用于香料复配及杏、香蕉、梨、菠萝等各种香味剂的成分。检定金属铊、锡和钨。测定钼和铼。抗生素萃取剂。

2.分析试剂及溶剂，用于铊、锡、钨、钼和铼等的测定。也用作塑料、喷漆、硝化棉、人造皮革等的溶剂。

3.化妆品溶剂。主要用作指甲油等化妆品的中沸点主溶剂,以溶解硝化纤维素、丙烯酸酯树脂、醇酸树脂等皮膜形成剂,经常与醋酸乙酯混合使用,添加量约为20%~25%。另外,也用于配制指甲油脱膜剂,添加量约为30%。

4.用作喷漆、人造革、胶片、硝化棉、树胶等溶剂及用于调制香料和药物。^[25]

乙酸丁酯物化性质

外观与性状：: 无色液体带有一种水果的气味
密度：: 0.88 g/mL at 25 °C(lit.)
熔点：: −78 °C(lit.)
沸点：: 124-126 °C(lit.)
闪点：: 74 °F
水溶解性：: 0.7 g/100 mL (20 ºC)
折射率：: n20/D 1.394(lit.)
蒸汽压：: 11.5mmHg at 25°C
蒸汽密度：: 4 (vs air)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂分开存放
稳定性相关：: 1.化学性质：与低级同系物相比，乙酸丁酯难溶于水，也较难水解。但在酸或碱的作用下，水解生成乙酸和丁醇。乙酸丁酯在石英管中加热至500℃时，分解为乙酸和丁烯。与氮一起通过500℃的玻璃棉时，主要生成1-丁烯，少量的副产物有丙烯、2-丁烯、乙烯等。以氧化铝为催化剂加热至300~330℃，生成氯丁烷、氯代异丁烷、乙酸异丁酯，以及少量的甲烷、乙烷、丙烷、丁烯等。与苯一起在氯化铝存在下加热生成丁基苯及少量4-丁基苯乙酮。将乙酸丁酯用丁醇钠处理生成乙酰乙酸丁酯。与异丙醇铝一起加热生成乙酸异丙酯和丁基铝。乙酸丁酯也能发生醇解、氨解、酯交换等酯类共有的反应。发生光氯化反应时，得到7.0% 1-氯取代物和30% 4-氯取代物。乙酸丁酯与三氯化铝形成加成化合物，该化合物在0℃时为液体，132℃以上分解。
2.稳定性^[21] 稳定
3.禁配物^[22] 强氧化剂、碱类、酸类
4.聚合危害^[23] 不聚合
其它信息：: 1.性状：无色透明液体，有水果香味。^[1]
2.熔点（℃）：-76.8^[2]
3.沸点（℃）：126.1^[3]
4.相对密度（水=1）：0.88^[4]
5.相对蒸气密度（空气=1）：4.1^[5]
6.饱和蒸气压（kPa）：1.2（20℃）^[6]
7.燃烧热（kJ/mol）：-3463.5^[7]
8.临界温度（℃）：305.9^[8]
9.临界压力（MPa）：3.1^[9]
10.辛醇/水分配系数：1.82^[10]
11.闪点（℃）：22（CC）^[11]
12.引燃温度（℃）：421^[12]
13.爆炸上限（%）：7.6^[13]
14.爆炸下限（%）：1.2^[14]
15.溶解性：微溶于水，溶于乙醇、乙醚、烃类等多数有机溶剂。^[15]
16.黏度（mPa·s,20ºC）：0.734
17.蒸发热（KJ/kg,b.p.）：309.3
18.生成热（KJ/mol）：499.9
19.比热容（KJ/(kg·K),19.41ºC,定压）：2.08
20.比热容（KJ/(kg·K),20ºC,定压）：1.91
21.电导率（S/m,25ºC）：13×10^-9
22.体膨胀系数（K^-1）：0.0011
23.临界压力（MPa）：3.14
24.偏心因子：0.410
25.溶度参数(J·cm^-3)^0.5：17.582
26.van der Waals面积（cm²·mol^-1）：1.049×10¹⁰
27.van der Waals体积（cm³·mol^-1）：73.230
28.气相标准燃烧热(焓)(kJ·mol^-1)：-3590.83
29.气相标准声称热(焓)( kJ·mol^-1) ：-485.22
30.液相标准燃烧热(焓)(kJ·mol^-1)：-3547.24
31.液相标准声称热(焓)( kJ·mol^-1)：-528.82
32.液相标准热熔(J·mol^-1·K^-1)：228

乙酸丁酯毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AF7350000

CHEMICAL NAME :: Acetic acid, butyl ester

CAS REGISTRY NUMBER :: 123-86-4

BEILSTEIN REFERENCE NO. :: 1741921

LAST UPDATED :: 199806

DATA ITEMS CITED :: 58

MOLECULAR FORMULA :: C6-H12-O2

MOLECULAR WEIGHT :: 116.18

WISWESSER LINE NOTATION :: 4OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,282,1943

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,515,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,196,1992 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ppm

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,282,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10768 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Liver - other changes

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,196,1992

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,7,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(11),57,1981

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 32,1241,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,2,1961

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 68 gm/m3/72M

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - emphysema

REFERENCE :: AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW. Volume(issue)/page/year: 5,1,1933

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,28,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >17600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 1,7,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,28,1982

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 67 gm/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - antipsychotic

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,515,1979

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 35,21,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2648 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,189,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(10),25,1988

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 40 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 32(10),25,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1592 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(5),61,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 ppm/6H/13W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 36(1,pt2),61,1997 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1500 ppm/7H

SEX/DURATION :: female 7-16 day(s) after conception

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB83-258038 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 950 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 713 mg/m3 (150 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 150 ppm (700 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,30,1971 OSHA PEL (Gen Indu):8H TWA 150 ppm (710 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 150 ppm (710 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 150 ppm (710 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 150 ppm (710 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 150 ppm (710 mg/m3);STEL 200 ppm (950 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 200 ppm (950 mg/m3) JAN 1993 OEL-BELGIUM:TWA 150 ppm (713 mg/m3);STEL 200 ppm (950 mg/m3) JAN 1993 OEL-DENMARK:TWA 150 ppm (710 mg/m3) JAN 1993 OEL-FINLAND:TWA 150 ppm (710 mg/m3);STEL 200 ppm (950 mg/m3) JAN 1993 OEL-FRANCE:TWA 150 ppm (710 mg/m3);STEL 200 ppm (940 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (950 mg/m3) JAN 1993 OEL-HUNGARY:TWA 200 mg/m3;STEL 600 mg/m3 JAN 1993 OEL-INDIA:TWA 150 ppm (710 mg/m3);STEL 200 ppm (950 mg/m3) JAN 1993 OEL-JAPAN:TWA 200 ppm (950 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 150 ppm (710 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 150 ppm (710 mg/m3) JAN 1993 OEL-POLAND:TWA 200 mg/m3 JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3 JAN 1993 OEL-SWEDEN:TWA 100 ppm (500 mg/m3);STEL 150 ppm (700 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 150 ppm (700 mg/m3);STEL 300 ppm JAN 1993 OEL-TURKEY:TWA 150 ppm (710 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 150 ppm (710 mg/m3);STEL 200 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO n-BUTYL ACETATE-air:10H TWA 150 ppm;STEL 200 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14380 No. of Facilities: 52224 (estimated) No. of Industries: 280 No. of Occupations: 153 No. of Employees: 527992 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14380 No. of Facilities: 55011 (estimated) No. of Industries: 271 No. of Occupations: 164 No. of Employees: 822099 (estimated) No. of Female Employees: 143606 (estimated)

毒理学数据：

1.急性毒性^[16]

LD50：10768mg/kg（大鼠经口）；＞17600mg/kg（兔经皮）

LC50：390ppm（大鼠吸入，4h）

2.刺激性^[17]

家兔经皮：500mg（24h），中度刺激。

家兔经眼：20mg，重度刺激。

3.亚急性与慢性毒性^[18] 猫吸入4200ppm，每天6h，共6d，衰弱，体重减轻，轻度血液变化。

生态数据：

1.生态毒性^[19]

LC50：100mg/L（96h）（蓝鳃太阳鱼）

EC50：18mg/L（96h）（黑头呆鱼）

TLm：44mg/L（48h）（水蚤）

IC50：280mg/L（72h）（藻类）

2.生物降解性 暂无资料

3.非生物降解性^[20] 空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为4d（理论）。

在20℃，当pH值为7，8，9时，水解半衰期分别为3.1a，114d，11d（理论）。

乙酸丁酯

乙酸丁酯制备方法及用途