1-亚硝基哌嗪
- 中文名称：
- 1-亚硝基哌嗪
- 中文别名：
-
- 英文名称：
- Piperazine, 1-nitroso-
- 英文别名：
- N-Nitrosopiperazine;
1-nitrosopiperazine
- CAS No.：
- 5632-47-3
- 分 子 式：
-
C4H9N3O
- 分 子 量：
- 115.16
- 精确分子量：
- 115.07500
- PSA：
- 44.70000
- InChI：
- The Key: CVTIZMOISGMZRJ-UHFFFAOYSA-N3
- 安全术语：
- Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
- 分子结构式：
-
- SDS：
- 查看
1-亚硝基哌嗪 物化性质
- 密度：
- 1.34g/cm3
- 沸点：
- 264.5ºC at 760mmHg
- 闪点：
- 113.8ºC
- 折射率：
- 1.601
1-亚硝基哌嗪 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM2450000
- CHEMICAL NAME :
- Piperazine, 1-nitroso-
- CAS REGISTRY NUMBER :
- 5632-47-3
- BEILSTEIN REFERENCE NO. :
- 0112147
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C4-H9-N3-O
- MOLECULAR WEIGHT :
- 115.16
- WISWESSER LINE NOTATION :
- T6M DNTJ DNO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
Lungs, Thorax, or Respiration - acute pulmonary edema
Liver - fatty liver degeneration
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5400 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Olfaction) - tumors
Reproductive - Tumorigenic effects - uterine tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg/20W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
Blood - tumors
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Bacteria - Escherichia coli
- DOSE/DURATION :
- 150 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 272,161,1992
