- 中文名称：
-
- 中文别名：
-
- 英文名称：
- Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
- 英文别名：
- N-[(7S)-10-amino-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide;
Colchicine amide;
Colchicein-amid;
Colchicamide;
Colchiceinamide;
Colchicamide (VAN);
(S)--7-Acetylamino-10-amino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on;
N-((S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide;
14-Aminocolchicide;
10-demethoxy-10-N-aminocolchicine;
Colchicamid;
SKF 3192;
Colchicenamide;
Colchicide,14-amino;
N-((S)-10-Amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid
- CAS No.：
- 3123-89-5
- 分 子 式：
-
C21H24N2O5
- 分 子 量：
- 384.4257
- 精确分子量：
- 384.16900
- PSA：
- 99.88000
- InChI：
- The Key: JWDFWIZNGSOUGC-INIZCTEOSA-N3
- 分子结构式：
-
- SDS：
- 查看
物化性质
- 密度：
- 1.28g/cm3
- 沸点：
- 722.2ºC at 760 mmHg
- 闪点：
- 390.6ºC
- 折射率：
- 1.61
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0710000
- CHEMICAL NAME :
- Colchicine, 10-amino-10-demethoxy-
- CAS REGISTRY NUMBER :
- 3123-89-5
- BEILSTEIN REFERENCE NO. :
- 2824077
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H24-N2-O5
- MOLECULAR WEIGHT :
- 384.47
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29600 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 98,236,1954
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 43 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 8900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 85,235,1920
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 160 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig,
Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
Volume(issue)/page/year: 85,235,1920
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg/24D-I
- TOXIC EFFECTS :
- Gastrointestinal - alteration in gastric secretion
Gastrointestinal - nausea or vomiting
Blood - changes in bone marrow (not otherwise specified)
- REFERENCE :
- CMJODS Chinese Medical Journal (Beijing, English Edition). (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-
1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year:
93,188,1980
推荐供应商
湖北萃园生物科技有限公司
秋水仙酰胺
- 联系人：马蕊
- 电 话：18162791556
- 手 机：18162791556
- Cas号：3123-89-5
- 包装：5mg,100mg
- 纯度：98%
- 价格：5.0元 - 10.0元
