Section I.Chemical Product and Company Identification
Chemical Name Glycolonitrile
(ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
Portland OR
Acetonitrile, 2-hydroxy- (CA INDEX NAME);
Synonym
Formaldehyde Cyanhydrin; Hydroxyacetonitrile
Chemical Formula C2H3NO
107-16-4
CAS Number
Section II. Composition and Information on Ingredients
Chemical Name CAS Number Percent (%) TLV/PEL Toxicology Data
Glycolonitrile 107-16-4 Not available. Not available. Rat LD50 (oral) 8 mg/kg
(ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
Rabbit LD50 (dermal) 5 mg/kg
Mouse LD50 (intraperitoneal) 3
mg/kg
Section III. Hazards Identification
Acute Health Effects Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health Effects CARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
many human organs.
Section IV. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
Skin Contact
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Inhalation If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.
Section V. Fire and Explosion Data
Not available.
Combustible. Auto-Ignition
Flammability
Flammable Limits Not available.
Flash Points 69°C (156.2°F)
Combustion Products These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NO, NO2).
WARNING: Very toxic cyanide gas may be produced in a fire. Do not inhale.
Fire Hazards Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Glycolonitrile
(ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
Section VI. Accidental Release Measures
Spill Cleanup Highly toxic material. Combustible material. Irritating material. Lachrymatory material.
Keep away from heat. Mechanical exhaust required. Stop leak if without risk. DO NOT get water inside container. DO NOT
Instructions
touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if
needed. Consult federal, state, and/or local authorities for assistance on disposal.
Section VII. Handling and Storage
Handling and Storage HIGHLY TOXIC. COMBUSTIBLE. IRRITANT. LACHRYMATORY. Keep locked up. Keep away from heat. Mechanical
exhaust required. Avoid excessive heat and light. DO NOT ingest. Do not breathe gas/fumes/ vapor/spray. Wear suitable
Information
protective clothing. If ingested, seek medical advice immediately and show the container or the label. Treat symptomatically
and supportively.
Always store away from incompatible compounds such as oxidizing agents.
Section VIII. Exposure Controls/Personal Protection
Engineering Controls Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
Personal Protection Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure Limits Not available.
Section IX. Physical and Chemical Properties
Physical state @ 20°C Liquid. (Clear, colorless.) Solubility Not available.
1.07 (water=1)
Specific Gravity
Molecular Weight 57.05 Partition Coefficient Not available.
Boiling Point 183°C (361.4°F) Vapor Pressure Not available.
Melting Point -67°C (-88.6°F) Vapor Density Not available.
Not available. Not available.
Refractive Index Volatility
Critical Temperature Not available. Odor Not available.
Not available. Not available.
Viscosity Taste
Section X. Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability Avoid excessive heat and light.
Incompatibilities Reactive with oxidizing agents.
Section XI. Toxicological Information
RTECS Number AM0350000
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Rat LD50 (oral) 8 mg/kg
Toxicity Data
Rabbit LD50 (dermal) 5 mg/kg
Mouse LD50 (intraperitoneal) 3 mg/kg
Chronic Toxic Effects CARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or many
human organs.
Acute Toxic Effects Toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or death.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Glycolonitrile
(ca. 52% in Water, ca. 9.7mol/L) (stabilized with H2SO4)
Section XII. Ecological Information
Ecotoxicity Not available.
Glycolonitrile's production and use as solvent and organic intermediate may result in its release to the environment through
Environmental Fate
various waste streams. If released to air, an estimated vapor pressure of 0.8 mm Hg at 25 deg C indicates glycolonitrile will
exist solely as a vapor. Vapor-phase glycolonitrile will be degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 21 days. If released to soil,
glycolonitrile is expected to have very high mobility based upon an estimated Koc of 1. Volatilization from moist soil surfaces
is not expected to be an important fate process based upon an estimated Henry's Law constant of 7.4X10-6 atm-cu m/mole.
Glycolonitrile is not expected to volatilize from dry soil surfaces based upon its vapor pressure. If released into water,
glycolonitrile is not expected to adsorb to suspended solids and sediment in water based upon the estimated Koc.
Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated
Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 61 hrs and 30 days,
respectively. An estimated BCF of 0.5 suggests the potential for bioconcentration in aquatic organisms is low. Occupational
exposure to glycolonitrile may occur through inhalation and dermal contact with this compound at workplaces where
glycolonitrile is produced or used.
Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.
Section XIV. Transport Information
DOT CLASS 6.1: Toxic material
DOT Classification
PIN Number
Proper Shipping Name Nitriles, toxic, liquid, n.o.s.
Packing Group (PG) I
DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.
(EPA)
WHMIS Classification CLASS B-3: Combustible liquid with a flash point between 37.8°C (100°F) and 93.3°C (200°F).
CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
(Canada)
On NDSL.
EINECS Number (EEC) 203-469-1
EEC Risk Statements
R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.
R36/37/38- Irritating to eyes, respiratory system and skin.
SECTION 16 - ADDITIONAL INFORMATION
N/A
