羟基乙酰氨基芴
- 中文名称：
- 羟基乙酰氨基芴
- 中文别名：
-
- 英文名称：
- Acetamide,N-9H-fluoren-2-yl-N-hydroxy-
- 英文别名：
- N-hydroxy-2-acetamidofluorene;
N-Hydroxy-2-faa;
Hydroxyacetylaminofluorene;
N-Hydroxy-2-acetamidofluorene;
Fluorenyl-2-acethydroxamic acid;
Acetamide,N-9H-fluoren-2-yl-N-hydroxy;
Nohfaa;
N-Hydroxy-aaf;
N-hydroxy-N-2-fluorenylacetamide;
Acetohydroxamic acid,N-fluoren-2-yl;
N-(9H-fluoren-2-yl)-N-hydroxyacetamide
- CAS No.：
- 53-95-2
- 分 子 式：
-
C15H13NO2
- 分 子 量：
- 239.29
- 精确分子量：
- 239.09500
- PSA：
- 40.54000
- InChI：
- The Key: SOKUIEGXJHVFDV-UHFFFAOYSA-N3
- 安全术语：
- Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. A poison by intraperitoneal route. Experimental teratogenic and other reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
羟基乙酰氨基芴 物化性质
- 外观与性状：
- 奶油色粉末
- 密度：
- 1.322g/cm3
- 熔点：
- 136 - 137ºC
- 沸点：
- 455.1ºC at 760mmHg
- 闪点：
- 229ºC
- 折射率：
- 1.696
羟基乙酰氨基芴 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AK8575000
- CHEMICAL NAME :
- Acetohydroxamic acid, N-fluoren-2-yl-
- CAS REGISTRY NUMBER :
- 53-95-2
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 100
- MOLECULAR FORMULA :
- C15-H13-N-O2
- MOLECULAR WEIGHT :
- 239.29
- WISWESSER LINE NOTATION :
- L B656 HHJ ENQV1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 52 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1000 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 120 mg/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 102 mg/kg/3W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2991 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Endocrine - tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 gm/kg/60W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - facilitates action of known carcinogen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 9800 mg/kg/56W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3880 mg/kg/40W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 13 gm/kg/94W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4700 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - ovarian tumors
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 8640 mg/kg/32W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 1250 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1075 mg/kg/16W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 142 mg/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 237 mg/kg/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 806 mg/kg/12W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 205 mg/kg/7W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2677 mg/kg/32W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 216 mg/kg/8W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Ear) - effect, not otherwise specified
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1344 mg/kg/20W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 485 mg/kg/9W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 61 mg/kg/5W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Morphological transformation
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA adduct
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA inhibition
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Mammal - dog Cells - not otherwise specified
- DOSE/DURATION :
- 100 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
42,3974,1982
*** REVIEWS ***
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971
TOXICOLOGY REVIEW
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution
Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-
1950- Volume(issue)/page/year: 13,271,1970
TOXICOLOGY REVIEW
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York,
NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983
羟基乙酰氨基芴 海关数据
中国海关编码：2924299090
- 概述：
- 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 包装
- 摘要/Summary：
- 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
