奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪
- 中文名称：
- 奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪
- 中文别名：
- 6-氨基-2-(氟甲基)-3-(2-甲基苯基)-4-(3H)-1,3-二氮杂萘酮;
4-[3-(2氯吩噻嗪-10-基)丙基]-1-呱嗪乙醇;
奋乃静;
过二苯嗪;
2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪
- 英文名称：
- 10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-
- 英文别名：
- prochlorperazine;
RP-6140;
Temetid;
Prochlorperazine;
proclorperazine;
Eskatrol;
Capazine;
6140 RP;
Emelent;
skf4657;
Nipodal
- CAS No.：
- 58-38-8
- 分 子 式：
-
C20H24ClN3S
- 分 子 量：
- 373.94
- 精确分子量：
- 373.13800
- PSA：
- 35.02000
- EINECS：
- 200-379-4
- InChI：
- The Key: WIKYUJGCLQQFNW-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 制备方法及用途
制备方法
N-(2-羟乙基)哌嗪与1,3-溴氯丙烷缩合得到1-(3-氯丙基)-4-(2-羟乙基)哌嗪。然后,将其与2-氯吩噻嗪缩合,制得奋乃静粗品。用乙酸乙酯重结晶,即得成品。
用途简介
用于治疗急慢性精神分裂症
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 物化性质
- 外观与性状：
- 透明淡黄色粘性液体
- 密度：
- 1.217g/cm3
- 熔点：
- 228 °C
- 沸点：
- 524.8ºC at 760mmHg
- 闪点：
- 271.2ºC
- 其它信息：
1.熔点（℃）：228。.
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 安全信息
- 包装等级：
- II
- 风险类别：
- 8
- 海关代码：
- 29159020
- WGK_Germany：
- 3
德国有关水污染物质的分类清单
- 安全说明：
- S26-S36/37/39-S45-S38-S28A-S36-S16
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO2700000
- CHEMICAL NAME :
- Phenothiazine,
2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-
- CAS REGISTRY NUMBER :
- 58-38-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C20-H24-Cl-N3-S
- MOLECULAR WEIGHT :
- 373.98
- WISWESSER LINE NOTATION :
- T C666 BN ISJ EG B3- AT6N DNTJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 2 mg/kg/24H-I
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
- REFERENCE :
- AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 30,234,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 560 ug/kg/10H-I
- TOXIC EFFECTS :
- Behavioral - headache
Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
312,1125,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 4500 ug/kg/3D-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- REFERENCE :
- BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford
St., London WC2E 9HD, UK) V.10(10)- 1956- Volume(issue)/page/year:
28,201,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,213,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 24,136,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 120,450,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: 6,722,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 152,1371,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For
publisher information, see PSCHDL. Volume(issue)/page/year: 2,209,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 16,255,1967
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 102 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,213,1973
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,213,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 120,450,1959
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 20400 ug/kg
- SEX/DURATION :
- female 51 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For
publisher information, see PSCHDL. Volume(issue)/page/year: 16,5,1969
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 80 mg/kg
- SEX/DURATION :
- female 1-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- 15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and
J.S. Perry, eds., Boston, Little, Brown & Co., 1965 Volume(issue)/page/year:
-,290,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- CAJPBD Proceedings of the Congenital Anomalies Research Association of
Japan. (Kyoto, Japan) No.1- 1961- Volume(issue)/page/year: 3,2,1963
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 12,346,1961
*** REVIEWS ***
TOXICOLOGY REVIEW
JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For
publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960
TOXICOLOGY REVIEW
IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79.
Discontinued. Volume(issue)/page/year: 1,203,1974
TOXICOLOGY REVIEW
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For
publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M1048
No. of Facilities: 58 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 230 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M1048
No. of Facilities: 134 (estimated)
No. of Industries: 1
No. of Occupations: 4
No. of Employees: 7332 (estimated)
No. of Female Employees: 6544 (estimated)
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：108.06
2、 摩尔体积（cm3/mol）：307.2
3、 等张比容（90.2K）：803.9
4、 表面张力（dyne/cm）：46.8
5、 极化率（10-24cm3）：42.84
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:4
4.可旋转化学键数量:4
5.互变异构体数量:无
6.拓扑分子极性表面积35
7.重原子数量:25
8.表面电荷:0
9.复杂度:429
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 上游产品
奋乃静; 丙氯拉嗪; 甲哌氯丙嗪; 2-氯-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪 下游产品
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苏州市晶华化工有限公司
丙氯拉嗪
- 联系人：屠先生
- 电 话：0512-52511818
- 手 机：13906222958
- Cas号：58-38-8
- 包装：2kg
- 纯度：98%-99%
- 价格：洽谈
湖北海易医药化工有限公司
奋乃静
- 联系人：张小敏
- 电 话：15927045175
- 手 机：15971427801
- Cas号：58-38-8
- 包装：洽谈
- 纯度：
- 价格：洽谈
天津士兰科技有限公司
奋乃静
- 联系人：赵平
- 电 话：022-26358246
- 手 机：15722085757
- Cas号：58-38-8
- 包装：洽谈
- 纯度：
- 价格：洽谈
