二溴甘露醇,488-41-5，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

海关数据

结构与计算化学

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二溴甘露醇

中文名称：: 二溴甘露醇

中文别名：: 二溴甘露醇;
1,6-二溴-1,6-二脱氧-D-甘露糖醇

英文名称：: D-Mannitol,1,6-dibromo-1,6-dideoxy-

英文别名：: 1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL;
myelobromol;
1.6-Dibrom-1.6-didesoxy-D-mannit;
dibromannit;
r54;
1.6-dibromo-1.6-dideoxy-D-mannitol;
dibromomannitol;
Mielobromol;
mieobromol;
1,6-dibromo-D-1,6-dideoxy-mannitol;
mitobronitol;
myebrol

CAS No.：: 488-41-5

分子式：: C₆H₁₂Br₂O₄

分子量：: 308.00

精确分子量：: 305.91000

PSA：: 80.92000

EINECS：: 207-676-8

InChI：: The Key: VFKZTMPDYBFSTM-KVTDHHQDSA-N3

危险品标志：

风险术语：: 45-22

安全术语：: Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Br⁻.

分子结构式：

SDS：: 查看

二溴甘露醇物化性质

密度：
2.117g/cm3

沸点：
511.2ºC at 760mmHg

闪点：
263ºC

折射率：
1.622

蒸汽压：
1.37E-12mmHg at 25°C

稳定性相关：
遇碱易分解,其水溶液能分解逸出氢溴酸。在干燥空气中稳定,无臭,味微苦。

其它信息：

1.       性状：白色结晶或结晶性粉末。
2.       熔点（ºC）：187。
3.       溶解性：易溶于浓氢溴酸及DMF。略溶于乙醇,微溶于水和丙酮。

二溴甘露醇安全信息

海关代码：
2905590090

WGK_Germany：
3
德国有关水污染物质的分类清单

危险类别码：
45-22

RTECS号：
OP2800000

安全标志：
S22:不要吸入粉尘。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
:

危险标志：
T: Toxic;

二溴甘露醇毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2800000

CHEMICAL NAME :
Mannitol, 1,6-dibromo-1,6-dideoxy-, D-

CAS REGISTRY NUMBER :
488-41-5

BEILSTEIN REFERENCE NO. :
1721919

LAST UPDATED :
199707

DATA ITEMS CITED :
36

MOLECULAR FORMULA :
C6-H12-Br2-O4

MOLECULAR WEIGHT :
308.00

WISWESSER LINE NOTATION :
E1YQYQYQYQ1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1500 mg/kg

TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
900 mg/kg

TOXIC EFFECTS :
Blood - normocytic anemia Blood - thrombocytopenia

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1240 mg/kg

TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
1370 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
1380 mg/kg

TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
900 mg/kg

TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2200 mg/kg

TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2200 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
1080 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
4950 mg/kg/33D-I

TOXIC EFFECTS :
Behavioral - ataxia Liver - other changes Blood - changes in leukocyte (WBC) count

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
5460 mg/kg/26W-I

TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - normocytic anemia Related to Chronic Data - death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
10920 mg/kg/26W-C

TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
9750 mg/kg/26W-I

TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
7000 mg/kg/26W-I

TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
300 mg/kg

SEX/DURATION :
female 9-14 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
3900 mg/kg

SEX/DURATION :
female 26 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
500 mg/kg

SEX/DURATION :
female 13 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
500 mg/kg

SEX/DURATION :
female 10 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
300 mg/kg

SEX/DURATION :
female 9 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
3900 mg/kg

SEX/DURATION :
male 26 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
150 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
150 mg/kg

SEX/DURATION :
female 11 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
300 mg/kg

SEX/DURATION :
female 12 day(s) after conception

TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear

TYPE OF TEST :
Sex chromosome loss and nondisjunction

TYPE OF TEST :
Heritable translocation test

TYPE OF TEST :
Cytogenetic analysis

TYPE OF TEST :
Sister chromatid exchange
MUTATION DATA

TYPE OF TEST :
DNA inhibition

TEST SYSTEM :
Rodent - rabbit Bone marrow

DOSE/DURATION :
730 umol/L

REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

二溴甘露醇海关数据

中国海关编码：2905590090

概述：

2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 包装

摘要/Summary：

2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

二溴甘露醇分子结构与计算化学数据

分子结构数据

1、摩尔折射率：57.47
2、摩尔体积（cm³/mol）：183.4
3、等张比容（90.2K）：477.7
4、表面张力（dyne/cm）：45.9
5、极化率（10-24cm3）：22.78

二溴甘露醇上游产品

D-甘露醇 1,4:3,6-双脱水甘露醇乙酰溴二脱水甘露醇 1,2-bis(2-bromo-1-hydroxyethyl)-3,3-dimethylcyclopropane-1,2-diol

二溴甘露醇下游产品

1,6-二脱氧-1,6-二碘-D-甘露醇 1,6-二溴-1,6-二脱氧-D-甘露醇2,3,4,5-四乙酸酯

推荐供应商

湖北诺纳科技有限公司

二溴甘露醇
联系人：张经理
电  话：027-59209883
手  机：17386169806
Cas号：488-41-5
包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：1.0元 - 25.0元
淄博航宇生物科技发展有限公司

二溴甘露醇
联系人：张经理
电  话：15666366704
手  机：15666366704
Cas号：488-41-5
包装：100kg
纯度：99%
价格：洽谈

二溴甘露醇

二溴甘露醇制备方法及用途

制备方法

合成制备方法

用途简介

用途

二溴甘露醇物化性质

二溴甘露醇安全信息

二溴甘露醇毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二溴甘露醇海关数据

中国海关编码：2905590090

二溴甘露醇分子结构与计算化学数据

分子结构数据

二溴甘露醇上游产品

二溴甘露醇下游产品

推荐供应商

湖北诺纳科技有限公司

二溴甘露醇

淄博航宇生物科技发展有限公司

二溴甘露醇

二溴甘露醇

二溴甘露醇 制备方法及用途

制备方法

合成制备方法

用途简介

用途

二溴甘露醇 物化性质

二溴甘露醇 安全信息

二溴甘露醇 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

二溴甘露醇 海关数据

中国海关编码：2905590090

二溴甘露醇 分子结构与计算化学数据

分子结构数据

二溴甘露醇 上游产品

二溴甘露醇 下游产品

推荐供应商

湖北诺纳科技有限公司

二溴甘露醇

淄博航宇生物科技发展有限公司

二溴甘露醇

二溴甘露醇制备方法及用途

二溴甘露醇物化性质

二溴甘露醇安全信息

二溴甘露醇毒理性

二溴甘露醇海关数据

二溴甘露醇分子结构与计算化学数据

二溴甘露醇上游产品

二溴甘露醇下游产品