制备方法

为口服抗凝血剂,其作用与华法灵钠相似,用药后18—24小时发挥作用,可维持24—48小时。用于血栓性静脉炎、肺栓塞、冠状动脉血栓、手术后血栓等。

用途简介

用途

为口服抗凝血剂，其作用与华法灵钠相似，用药后18—24小时发挥作用，可维持24—48小时。用于血栓性静脉炎、肺栓塞、冠状动脉血栓、手术后血栓等。

包装等级：

III

风险类别：

6.1(b)

海关代码：

2914399090

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R25

安全说明：

S36/37/39-S45

RTECS号：

NK6125000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：

T: Toxic;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NK6125000

CHEMICAL NAME :

1,3-Indandione, 2-phenyl-

CAS REGISTRY NUMBER :

83-12-5

LAST UPDATED :

199512

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C15-H10-O2

MOLECULAR WEIGHT :

222.25

WISWESSER LINE NOTATION :

L56 BV DV CHJ CR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

42500 ug/kg/17D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - urine volume decreased

REFERENCE :

BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,1655,1963

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

48 mg/kg/27D-I

TOXIC EFFECTS :

Blood - other changes Nutritional and Gross Metabolic - body temperature increase

REFERENCE :

NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O. Box 156, Wellington, New Zealand) V.1- 1900- Volume(issue)/page/year: 57,283,1958

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

22 mg/kg/17D-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - interstitial nephritis Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 52,706,1960

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

90 mg/kg/27D-I

TOXIC EFFECTS :

Liver - hepatitis (hepatocellular necrosis), diffuse Skin and Appendages - dermatitis, allergic (after systemic exposure)

REFERENCE :

CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 77,1028,1957

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

1683 mg/kg/31D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :

LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,920,1963

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

163 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,519,1974

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

190 mg/kg

TOXIC EFFECTS :

Behavioral - rigidity (including catalepsy) Behavioral - muscle contraction or spasticity

REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 16,34,1961

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

175 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 90,213,1960

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

150 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 27,520,1972

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

140 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 8,289,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

130 mg/kg

TOXIC EFFECTS :

Behavioral - rigidity (including catalepsy) Behavioral - muscle contraction or spasticity

REFERENCE :

THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 16,34,1961 *** REVIEWS *** TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965

毒理学数据：

急性毒性：

人口径TDL0：42500 ug/kg/17D-I; 人口径LDL0：48mg/kg/17D-I; 人TDL0：22mg/kg/17D-I

人LDL0：1683mg/kg/31D-I;

大鼠口径LD50：163 mg/kg；大鼠腹腔LD50：190 mg/kg

小鼠口径LD50：175 mg/kg；小鼠皮下LD50：140mg/kg；

小鼠静脉LD50：130mg/kg；

中国海关编码：2914399090

概述：

2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 丙酮报明包装

摘要/Summary：

2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

分子结构数据

        1、   摩尔折射率：63.13

2、   摩尔体积（m³/mol）：175.7

3、   等张比容（90.2K）：474.6

4、   表面张力（dyne/cm）：53.2

5、   极化率（10^-24cm³）：25.02

 

计算化学数据

1、  疏水参数计算参考值（XlogP）：2.9

2、  氢键供体数量：0

3、  氢键受体数量：2

4、  可旋转化学键数量：1

5、  互变异构体数量：2

6、  拓扑分子极性表面积（TPSA）：34.1

7、  重原子数量： 17

8、  表面电荷：0

9、  复杂度：304

10、    同位素原子数量：0

11、    确定原子立构中心数量：0

12、    不确定原子立构中心数量：0

13、    确定化学键立构中心数量：0

14、    不确定化学键立构中心数量：0

15、    共价键单元数量：1

• 
  2-苯基-1
• 
  3-茚满二酮质谱(MS)
• 
  2-苯基-1
• 
  3-茚满二酮核磁图(¹³CNMR)
• 
  2-苯基-1