海关代码：

34021300

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R36/37/38

安全说明：

S24/25

RTECS号：

WG2933500

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WG2933500

CHEMICAL NAME :

Sorbitan, monostearate

CAS REGISTRY NUMBER :

1338-41-6

LAST UPDATED :

199710

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C24-H46-O6

MOLECULAR WEIGHT :

430.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

31 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 21,348,1956 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2730 gm/kg/2Y-C

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,315,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

635 gm/kg

SEX/DURATION :

multigenerations

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :

JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1270 gm/kg

SEX/DURATION :

female 84 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 60,489,1956 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81999 No. of Facilities: 693 (estimated) No. of Industries: 15 No. of Occupations: 25 No. of Employees: 14579 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81999 No. of Facilities: 6199 (estimated) No. of Industries: 63 No. of Occupations: 72 No. of Employees: 189741 (estimated) No. of Female Employees: 71370 (estimated)

毒理学数据：

急性毒性：小鼠口经LC50：31gm/kg；

生态数据：

通常来说对水是无害的，若无政府许可，勿将材料排入周围环境。

 

分子结构数据

1、   摩尔折射率：119.16

2、   摩尔体积（cm³/mol）：407.4

3、   等张比容（90.2K）：1050.7

4、   表面张力（dyne/cm）：44.2

5、   极化率（10^-24cm³）：47.24

计算化学数据

1、   疏水参数计算参考值（XlogP）：6.9

2、   氢键供体数量：3

3、   氢键受体数量：6

4、   可旋转化学键数量：20

5、   拓扑分子极性表面积（TPSA）：96.2

6、   重原子数量：30

7、   表面电荷：0

8、   复杂度：417

9、   同位素原子数量：0

10、   确定原子立构中心数量：4

11、   不确定原子立构中心数量：0

12、   确定化学键立构中心数量：0

13、   不确定化学键立构中心数量：0

14、   共价键单元数量：1

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  山梨醇单硬脂酸酯红外图谱(IR1)
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  山梨醇单硬脂酸酯红外图谱(IR2)
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  山梨醇单硬脂酸酯红外图谱(IR3)