制备方法

生化研究。医药（血管舒张药）。

用途简介

用途

生化研究。医药（血管舒张药）。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

EE1530000

CHEMICAL NAME :

Bradykinin

CAS REGISTRY NUMBER :

58-82-2

LAST UPDATED :

199206

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C50-H73-N15-O11

MOLECULAR WEIGHT :

1060.38

WISWESSER LINE NOTATION :

T5NTJ AVYZ3MYZUM BV- AT5NTJ BVM1VMY1R&VMY1QV- AT5NTJ BVMY1R&VMYVQ3MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

25 ug/kg

SEX/DURATION :

female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

DOSE :

25 ug/kg

SEX/DURATION :

female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Rodent - mouse Embryo

DOSE/DURATION :

500 ug/L

REFERENCE :

DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933- Volume(issue)/page/year: 282,173,1985

毒理学数据：

1、繁殖毒性：雌性小鼠静脉TDLo：25ug/kg，7-12天后受孕；雌性小鼠静脉TDLo：25ug/kg，7-12天后受孕

2、致突变性：DNA的inhibitionTEST系统：人类细胞-不是另有规定：15nmol/L；