哌唑嗪
- 中文名称:
- 哌唑嗪
- 中文别名:
- 哌唑嗪;
1-(4-氨基-6,7-二甲氧基-2-喹唑啉基-4-(2-呋喃基羰基))哌嗪
- 英文名称:
- Prazosin
- 英文别名:
- prazosin;
[14C]-Prazosin;
Prazosinum [INN-Latin];
Minipress;
(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone;
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone;
[125I]-Prazosin;
Prazosinum;
4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl furan-2-yl ketone;
[Bodipyl-FL]-Prazosin;
Prazosine;
Prazosina;
Furazosin;
Prazosina [INN-Spanish];
2-[4-(2-furoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxy-quinazoline;
Prazosine [INN-French];
Lentopres
- CAS No.:
- 19216-56-9
- 分 子 式:
-
C19H21N5O4
- 分 子 量:
- 383.41
- 精确分子量:
- 383.15900
- PSA:
- 107.68000
- EINECS:
- 242-885-8
- InChI:
- InChI=1/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)3
- 危险品标志:
-
- 风险术语:
-
- 安全术语:
-
- 分子结构式:
-
- SDS:
- 查看
哌唑嗪 物化性质
- 密度:
- 1.352g/cm3
- 熔点:
- 278-280ºC
- 沸点:
- 638.4ºC at 760mmHg
- 闪点:
- 339.9ºC
- 折射率:
- 1.651
- 蒸汽压:
- 3.4E-16mmHg at 25°C
- 存储条件/存储方法:
- 库房通风低温干燥
哌唑嗪 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA1300000
- CHEMICAL NAME :
- Quinazoline,
4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)-
- CAS REGISTRY NUMBER :
- 19216-56-9
- BEILSTEIN REFERENCE NO. :
- 0768345
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C19-H21-N5-O4
- MOLECULAR WEIGHT :
- 383.45
- WISWESSER LINE NOTATION :
- T66 BN DNJ C- AT6N DNTJ DV- BT5OJ&& EZ HO1 IO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 20 ug/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Gastrointestinal - nausea or vomiting
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
97,455,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 1143 ug/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 213,157,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 280 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptions
Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,508,1976
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1260 ug/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,622,1978
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4734418
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica,
Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year:
128,129,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 50,182,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg/60D-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight
Vascular - BP lowering not characterized in autonomic section
Endocrine - changes in adrenal weight
- REFERENCE :
- ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena,
Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
Volume(issue)/page/year: 45,109,1993
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2571 ug/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
- REFERENCE :
- AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430
Stockholm, Sweden) V.52-224, 1919-88. Volume(issue)/page/year: 213,319,1983
哌唑嗪 海关数据
中国海关编码:2934999090
- 概述:
- 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素:
- 品名, 成分含量, 用途
- 摘要/Summary:
- 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
哌唑嗪 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值(XlogP):无
2.氢键供体数量:1
3.氢键受体数量:8
4.可旋转化学键数量:4
5.互变异构体数量:3
6.拓扑分子极性表面积:107
7.重原子数量:28
8.表面电荷:0
9.复杂度:544
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
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