产品名称

盐酸拓扑替康

CAS NO

119413-54-6

中文别名

盐酸拓盐酸拓扑替坎;盐酸拓扑特康

英文名称

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-

英文别名

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-(9CI); 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-;Hycamtin; NSC 609669; Nogitecan hydrochloride; SKF 104864A; SKFS 104864A; Topotecan hydrochloride

分子式

C₂₃H₂₃N₃O₅^.ClH

分子量

457.91

EINECS

601-607-9

熔点

213-218oC

沸点

782.9oC at 760mmHg

毒性

盐酸拓扑替康
中文别名：盐酸拓盐酸拓扑替坎; 盐酸拓扑特康; 盐酸拓普替康; 拓扑替康盐酸盐
英文名称：Topotecan Hydrochloride
英文别名：(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride; Nogitecan hydrochloride; Hycamtin; Topotecan HCl; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride (1:1); (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-((Dimethylamino)Methyl)-4-Ethyl-4,9-Dihydroxy-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione Hydrochloride
CAS号： 119413-54-6
分子式：C23H23N3O5
分子量：421.4458
分子结构：
密度：1.49g/cm3
熔点：213-218℃
沸点：782.9°C at 760 mmHg
闪点：427.3°C
蒸汽压：8.13E-26mmHg at 25°C
理化性质：浅黄色针状结晶或结晶粉末
临床应用：可应用于所有实体肿瘤的治疗，是目前好的治疗卵巢癌的药物;对乳腺癌、直肠癌、结肠癌、急慢性白细胞病的治疗
产品用途：用作抗肿瘤药