1,2,3-三氯丙烷,96-18-4，生产厂家，价格-洛克化工网移动版

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1,2,3-三氯丙烷

中文名称：: 1,2,3-三氯丙烷

中文别名：: 1,2,3-三氯丙烷;
三氯丙烷

英文名称：: 1,2,3-trichloropropane

英文别名：: 1,2,3-Trichloropropane;
1,2,3-Trichlor-propan;
1,2,3-trichloro propane;
Glycerol trichlorohydrin;
Allyl trichloride;
Glyceryl trichlorohydrin;
Propane,1,2,3-trichloro;
Trichlorohydrin

CAS No.：: 96-18-4

分子式：: C₃H₅Cl₃

分子量：: 147.43

精确分子量：: 145.94600

PSA：: 0.00000

MDL：: MFCD00000946

EINECS：: 202-486-1

BRN：: 1732068

InChI：: InChI=1/C3H5Cl3/c4-1-3(6)2-5/h3H,1-2H23

危险品标志：: T

风险术语：: R20/21/22;R45;R60

安全术语：: S45;S53

分子结构式：

SDS：: 查看

1,2,3-三氯丙烷物化性质

外观与性状：: 无色至稻黄色的液体带有一种刺鼻的,像氯仿一样的气味
密度：: 1.387 g/mL at 25 °C(lit.)
熔点：: -14 °C
沸点：: 156 °C(lit.)
闪点：: 180 °F
水溶解性：: 2 g/L (25 ºC)
折射率：: n20/D 1.484(lit.)
存储条件/存储方法：: 库房通风低温干燥,与食品添加剂分开存放
稳定性相关：: 1.对金属略有腐蚀性，有水存在时，分解出腐蚀性强的氯化氢，光照可加速这一分解。对久贮或回收的1,2,3-三氯丙烷在使用前要检查其酸度。热解或燃烧时产生有毒气体，故应防止与赤热的物体接触。
2.与固体氢氧化钾一起加热时，脱去氯化氢，反应的主要产物为1,3-二氯丙烯和少量的2,3-二氯丙烯。与水或碳酸氢钠水溶液在铜存在下加压加热生成甘油。
3.稳定性^[23] 稳定
4.禁配物^[24] 强氧化剂、强碱
5.避免接触的条件^[25] 潮湿空气、光照、受热
6.聚合危害^[26] 不聚合
7.分解产物^[27] 氯化氢
其它信息：: 1.性状：无色至淡黄色液体，有氯仿味。^[1]
2.熔点（℃）：-14.7^[2]
3.沸点（℃）：156.8^[3]
4.相对密度（水=1）：1.39（20℃）^[4]
5.相对蒸气密度（空气=1）：5.0^[5]
6.饱和蒸气压（kPa）：1.33（46℃）^[6]
7.燃烧热（kJ/mol）：-1733.0^[7]
8.临界压力（MPa）：3.87^[8]
9.辛醇/水分配系数：2.27^[9]
10.闪点（℃）：71.1（CC）；82.2（OC）^[10]
11.引燃温度（℃）：304^[11]
12.爆炸上限（%）：12.6^[12]
13.爆炸下限（%）：3.2^[13]
14.溶解性：微溶于水，溶于乙醇、乙醚、油类、脂类、石蜡。^[14]
15.黏度（mPa·s,20ºC）：0.2505
16.闪点（ºC,闭口）：73.3
17.闪点（ºC,开口）：78.9
18.蒸气压（kPa,9.0ºC）：0.13
19.蒸气压（kPa,46.0ºC）：1.33
20.蒸发热（KJ/mol,b.p.）：40.56
21.燃烧热（KJ/mol,液体）：1735.9
22.比热容（KJ/(kg·K),20ºC）：1.235
23.体膨胀系数（K^-1,20ºC）：0.00096
24.相对密度（25℃，4℃）：1.3832
25.常温折射率（n²⁵）：1.4812
26.溶度参数(J·cm^-3)^0.5：20.148
27.van der Waals面积（cm²·mol^-1）：8.690×10⁹
28.van der Waals体积（cm³·mol^-1）：62.720
29.气相标准声称热(焓)( kJ·mol^-1) ：-182.9
30.液相标准声称热(焓)( kJ·mol^-1)：-230.6
31.液相标准热熔(J·mol^-1·K^-1)：172.4

1,2,3-三氯丙烷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TZ9275000

CHEMICAL NAME :: Propane, 1,2,3-trichloro-

CAS REGISTRY NUMBER :: 96-18-4

BEILSTEIN REFERENCE NO. :: 1732068

LAST UPDATED :: 199712

DATA ITEMS CITED :: 56

MOLECULAR FORMULA :: C3-H5-Cl3

MOLECULAR WEIGHT :: 147.43

WISWESSER LINE NOTATION :: G1YG1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 505 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Blood - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 369 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Blood - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Blood - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1770 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 340 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2720 mg/kg/17W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1179 mg/kg/10D-I

TOXIC EFFECTS :: Cardiac - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 297 ppm/6H/4W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Related to Chronic Data - changes in ovarian weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/m3/24H/94D-C

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5355 mg/kg/17W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3120 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 60 mg/m3 (10 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,223,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,223,1995 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,223,1995 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 50 ppm (300 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,266,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (60 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (60 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 50 ppm (300 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (300 mg/m3);STEL 75 ppm (450 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (300 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (300 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (300 mg/m3) JAN 1993 OEL-RUSSIA:STEL 2 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (300 mg/m3);STEL 250 ppm (1500 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (300 mg/m3);STEL 75 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,2,3-TRICHLOROPROPANE-air:10H CA TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 73960 No. of Facilities: 108 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 490 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 73960 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 492 (estimated) No. of Female Employees: 10 (estimated)

毒理学数据：

1.急性毒性^[15]

LD50：108μl（150mg）/kg（大鼠经口）；369mg/kg（小鼠经口）；372μl（517mg）/kg（兔经皮）

LC50：3400mg/m³（小鼠吸入，2h）

2.刺激性^[16]

家兔经皮：500μl（24h），轻度刺激。

家兔经眼：100μl，中度刺激。

3.致突变性^[17] 微生物致突变：鼠伤寒沙门菌500ng/皿。DNA损伤：人淋巴细胞2mmol/L。细胞遗传学分析：大鼠吸入800μg/L。姐妹染色单体交换：仓鼠肺300μmol/L。

4.致癌性^[18] IARC致癌性评论：G2A，可能人类致癌物。

生态数据：

1.生态毒性^[19]

LC50：42mg/L（7d）（虹鳉）；109mg/L（48h）（青鳉）

EC50：45mg/L（24h）（水蚤）

2.生物降解性^[20]

好氧生物降解（h）：4320~8640

厌氧生物降解（h）：17280~34560

3.非生物降解性^[21]

空气中光氧化半衰期（h）：61~613

一级水解半衰期（h）：44

4.其他有害作用^[22] 该物质对环境有危害，在地下水中有蓄积作用。

1,2,3-三氯丙烷 MSDS

国标编号:	61559
ＣＡＳ:	96-18-4
中文名称:	1，2，3-三氯丙烷
英文名称:	1，2，3-trichloropropane
别名:
分子式:	C₃H₅Cl₃；CH₂ClCHClCH₂Cl
分子量:	147.44
熔点:	-14.7℃ 沸点：156.2?
密度:	相对密度(水=1)1.39
蒸汽压:	82℃
溶解性:	微溶于水，溶于油类
稳定性:	稳定
外观与性状:	无色液体
危险标记:	14(有毒品)
用途:	用作溶剂

2、对环境的影响
该物质对环境可能有危害,在地下水中有蓄积作用。

一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：本品具有麻醉作用。急性接触时，有较强的呼吸道及局部刺激作用。经皮吸收亦可引起中毒。

二、毒理学资料及环境行为

急性毒性：LD50320mg/kg(大鼠经口)；1770mg/kg(兔经皮)；LC503400mg/m3,2小时(小鼠吸入)
危险特性：与强氧化剂接触可发生化学反应。受热易分解，燃烧时产生有毒的氯化物气体。遇潮湿空气能水解生成微量的氯化氢，光照亦能促进水解而对金属的腐蚀性增强。
燃烧(分解)产物：一氧化碳、二氧化碳、氯化氢。

3、现场应急监测方法
　

4、实验室监测方法
监测方法来源类别
气相色谱法；
色谱/质谱法《固体废弃物试验与分析评价手册》中国环境监测总站等译固体废弃物
色谱/质谱法《水和废水标准检验法》19版译文，江苏省环境监测中心水和废水
色谱/质谱法美国EPA524.2方法水质
空气中样品的测定：样品用活性炭吸附、二硫化碳洗脱，再用气相色谱法测定(NIOSH法)

5、环境标准
前苏联车间空气中有害物质的最高容许浓度 2mg/m3
前苏联(1978)生活饮用水和娱乐用水水体中有害物质的最大允许浓度 0.07mg/L

6、应急处理处置方法
一、泄漏应急处理

迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土、蛭石或其它惰性材料吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
废弃物处置方法：建议用焚烧法处置。废料同其它燃料混合后焚烧。燃烧要充分，防止生成光气。焚烧炉排气中的卤化氢通过酸洗涤器除去。

二、防护措施

呼吸系统防护：空气中浓度超标时，应选择佩带自吸过滤式防毒面具(半面罩)。紧急事态抢救或撤离时，佩戴氧气呼吸器。
眼睛防护：戴安全防护眼镜。
身体防护：穿透气型防毒服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，沐浴更衣。单独存放被毒物污染的衣服，洗后备用。

三、急救措施

皮肤接触：脱去被子污染的衣着，用肥皂水和清水彻底冲洗皮肤。就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。

灭火方法：消防人员须佩戴防毒面具、穿全身消防服。喷水保持火场容器冷却，直至灭火结束。灭火剂：雾状水、泡沫、二氧化碳、砂土。

1,2,3-三氯丙烷

1,2,3-三氯丙烷制备方法及用途

制备方法

合成制备方法

用途简介

用途

1,2,3-三氯丙烷物化性质

1,2,3-三氯丙烷安全信息

1,2,3-三氯丙烷毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2,3-三氯丙烷 MSDS

1,2,3-三氯丙烷分子结构与计算化学数据

分子结构数据

计算化学数据

1,2,3-三氯丙烷上游产品

1,2,3-三氯丙烷下游产品

1,2,3-三氯丙烷表征图谱

推荐供应商

1,2,3-三氯丙烷

1,2,3-三氯丙烷 制备方法及用途

制备方法

合成制备方法

用途简介

用途

1,2,3-三氯丙烷 物化性质

1,2,3-三氯丙烷 安全信息

1,2,3-三氯丙烷 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

1,2,3-三氯丙烷 MSDS

1,2,3-三氯丙烷 分子结构与计算化学数据

分子结构数据

计算化学数据

1,2,3-三氯丙烷 上游产品

1,2,3-三氯丙烷 下游产品

1,2,3-三氯丙烷 表征图谱

推荐供应商

1,2,3-三氯丙烷制备方法及用途

1,2,3-三氯丙烷物化性质

1,2,3-三氯丙烷安全信息

1,2,3-三氯丙烷毒理性

1,2,3-三氯丙烷分子结构与计算化学数据

1,2,3-三氯丙烷上游产品

1,2,3-三氯丙烷下游产品

1,2,3-三氯丙烷表征图谱