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四溴乙烷

中文名称：: 四溴乙烷

中文别名：: 1,1,2,2-四溴乙烷;
均四溴乙烷;
四溴乙烷;
四溴乙烷ZC-4;
对称四溴乙烷

英文名称：: Tetrabromoethane

英文别名：: 1,1,2,2-Tetrabromoethane;
Tetrabromoacetylene;
sym-Tetrabromoethane;
tetrabromo-1,1,2,2 ethane;
s-Tetrabromoethane;
Muthmanns liquid;
Ethane,1,1,2,2-tetrabromo;
1,1,2,2,-tetrabromoethane;
Acetylene tetrabromide

CAS No.：: 79-27-6

分子式：: C₂H₂Br₄

分子量：: 345.65

精确分子量：: 341.68900

PSA：: 0.00000

MDL：: MFCD00000133

EINECS：: 201-191-5

BRN：: 1098321

InChI：: InChI=1/C2H2Br4/c3-1(4)2(5)6/h1-2H3

危险品标志：: T+T

风险术语：: R26;R36;R52/53;

安全术语：: S24;S27;S45;S61;S1/2;

分子结构式：

SDS：: 查看

四溴乙烷制备方法及用途

制备方法

1.由乙炔和溴素加成而得。将溴素加入搪玻璃反应锅内,加入少量水以封闭溴素液面。然后从液下徐徐通入乙炔气体,保持在58-62℃,0.02-0.05MPa的条件下通气反应5-7小时,待反应液渐呈黄色即停止反应。将反应液用稀碳酸钠溶液洗涤,再用清水洗涤至中性,分净洗水,得四溴乙烷成品。原料消耗定额:溴素1110kg/t、电石1940kg/t。 2.将净化了的乙炔直接通入事先放入溴素及水的反应器中,控制压力1.9613～4.9033KPa、反应温度

合成制备方法

1.由乙炔和溴素加成而得。将溴素加入搪玻璃反应锅内，加入少量水以封闭溴素液面。然后从液下徐徐通入乙炔气体，保持在58-62℃，0.02-0.05MPa的条件下通气反应5-7小时，待反应液渐呈黄色即停止反应。将反应液用稀碳酸钠溶液洗涤，再用清水洗涤至中性，分净洗水，得四溴乙烷成品。原料消耗定额：溴素1110kg/t、电石1940kg/t。

2.将净化了的乙炔直接通入事先放入溴素及水的反应器中，控制压力1.9613～4.9033KPa、反应温度<50℃条件下进行反应，然后用稀碱液洗涤，除去上层碱液后，用水洗，制得成品。

用途简介

1.该品用作季胺化合物、医药、染料的中间体,用作添加型阻燃剂,也用作合成季胺化合物、医药、染料的中间体,还用于制取化学纤维助催化剂、涤纶氧化工序的引发剂、制冷剂、灭火剂和熏蒸消毒剂等。用作显微镜检查用试剂、浮选剂和溶剂等。 2.用于选矿及作为溶剂等。

用途

1.该品用作季胺化合物、医药、染料的中间体，用作添加型阻燃剂，也用作合成季胺化合物、医药、染料的中间体，还用于制取化学纤维助催化剂、涤纶氧化工序的引发剂、制冷剂、灭火剂和熏蒸消毒剂等。用作显微镜检查用试剂、浮选剂和溶剂等。

2.用于选矿及作为溶剂等。^[18]

四溴乙烷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI8225000

CHEMICAL NAME :: Ethane, 1,1,2,2-tetrabromo-

CAS REGISTRY NUMBER :: 79-27-6

BEILSTEIN REFERENCE NO. :: 1098321

LAST UPDATED :: 199712

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C2-H2-Br4

MOLECULAR WEIGHT :: 345.68

WISWESSER LINE NOTATION :: EYEYEE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 549 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 269 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Liver - fatty liver degeneration Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/13W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Liver - changes in liver weight Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/4H/17W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Liver - changes in liver weight Blood - hemorrhage

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 ppm/7H/14W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 ppm/7H/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 ppm/7H/15W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 14 ppm/7H/15W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 14 ppm/7H/14W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4 ppm/7H/26W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 gm/kg/74W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 158 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-TWA 14 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (14 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,248,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (14 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (15 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-FINLAND:TWA 1 ppm (14 mg/m3);STEL 3 ppm (42 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (15 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (14 mg/m3);STEL 2 ppm (28 mg/m3) JAN 1993 OEL-TURKEY:TWA 1 ppm (14 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 ppm (7 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 71401 No. of Facilities: 39 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 440 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 71401 No. of Facilities: 172 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 2516 (estimated)

毒理学数据：

1.急性毒性^[12]

LD50：1200mg/kg（大鼠经口）；5250mg/kg（大鼠经皮）

LC50：549mg/m³（大鼠吸入，4h）

2.刺激性^[13]

家兔经皮：500mg（24h），中度刺激。

家兔经眼：100mg，轻度刺激。

3.亚急性与慢性毒性^[14] 慢性毒性试验各种动物肝重都增加，肝、肾有病理改变。

生态数据：

1.生态毒性^[15] LC50：19mg/L（48h）（青鳉）

2.生物降解性^[16] MITI-I测试，初始浓度100ppm，污泥浓度30ppm，2周后降解29%。

3.非生物降解性 暂无资料

四溴乙烷 MSDS

国标编号:	61566
ＣＡＳ:	79-27-6
中文名称:	1,1,2,2-四溴乙烷
英文名称:	1,1,2,2-Tetrabromoethane；Acetylene tetrabromide
别名:	四溴化乙炔
分子式:	C₂H₂Br₄；Br₂HCCHBr₂
分子量:	345.65
熔点:	-1～1℃ 沸点：243.5?
密度:	相对密度(水=1)2.96
蒸汽压:
溶解性:	不溶于水，溶于乙醇、氯仿等多数有机溶剂
稳定性:	稳定
外观与性状:	黄色重液，带有樟脑及氯仿臭味
危险标记:	15(有害品，远离食品)
用途:	用于选矿及作为溶剂

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：对中枢神经系统有抑制作用，对呼吸道有刺激作用，可引起肝、肾损害及单核细胞增多，可引起皮炎。

二、毒理学资料及环境行为

毒性：剧毒。
急性毒性：LD501200mg/kg(大鼠经口)；5250mg/kg(大鼠经皮)；LC50549mg/m3，4小时(大鼠吸入)；大鼠吸入0.5g/m3×3小时，眼、鼻粘膜刺激，2～3小时麻醉，1～5天内死亡；狗吸入9～36g/m3呼吸困难，呕吐，运动失调5天死亡，尸检肺和其他内脏出血。
亚急性和慢性毒性：大/豚鼠吸入0.056g/m3×7小时/日×5日/周×100～106日，肝有轻度病变。
致突变性：Ames试验鼠伤寒沙门氏菌 +S9阴性

危险特性：受高热分解产生有毒的溴化物气体。
燃烧(分解)产物：一氧化碳、二氧化碳、溴化氢。

3.现场应急监测方法:
　

4.实验室监测方法:
色谱-质谱法《环境监测资料，1986(1-2)》中国环境监测总站
空气中样品的测定：样品用硅胶吸附后，经THF处理，再用气相色谱法分析。

5.环境标准:
前苏联车间空气中有害物质的最高容许浓度 1mg/m3

6.应急处理处置方法:
一、泄漏应急处理

疏散处理污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴自给式呼吸器，穿化学防护服。不要直接接触泄漏物，在确保安全情况下堵漏。用砂土或其它不燃性吸附剂混合吸收，然后收集运至废物处理场所处置。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。
废弃物处置方法：用焚烧法。废料同易燃的燃料混合后焚烧，焚烧炉排气中的卤化氢通过酸洗涤器除去。

二、防护措施

呼吸系统防护：空气中浓度超标时，应该佩带防毒面具。紧急事态抢救或逃生时，佩带自给式呼吸器。
眼睛防护：一般不顼特殊防护，高浓度接触时可戴安全防护眼镜。
防护服：穿相应的防护服。
手防护：必要时戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。单独存放被毒物污染的衣服，洗后再用。注意个人清洁卫生。

三、急救措施

皮肤接触：立即脱去污染的衣着，用肥皂水及清水彻底冲洗。
眼睛接触：立即提起眼睑，用大量流动清水彻底冲洗。
吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：误服者饮大量温水，催波士顿，洗胃。就医。

灭火方法：不燃。火场周围可用的灭火介质。

武汉吉鑫益邦生物科技有限公司

1,1,2,2-四溴乙烷

联系人：周美玲
电话：027-59768650
手机：15629090339

Cas号：79-27-6
包装：1kg,25kg,200kg,400kg,500kg
纯度：0-99%
价格：洽谈

四溴乙烷

四溴乙烷制备方法及用途