支链氨基酸
- 中文名称：
- 支链氨基酸
- 中文别名：
- 尼古丁;
烟碱;
(S)-3-(1-甲基-2-吡咯烷基)吡啶;
(S)-(-)-尼古丁
- 英文名称：
- Nicotine
- 英文别名：
- Nicotine;
(-)-Nicotine;
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine;
3-[(2S)-1-methyl-2-pyrrolidinyl]pyridine;
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine;
nicotine;
L-Nicotine
- CAS No.：
- 54-11-5
- 分 子 式：
- C10H14N2
- 分 子 量：
- 162.23200
- 精确分子量：
- 162.11600
- PSA：
- 16.13000
- MDL：
- MFCD00006369
- EINECS：
- 200-193-3
- BRN：
- 82109
- InChI：
- InChI=1/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/p+1/t10-/m1/s13
- 风险术语：
- 25-27-51/53-36-20/21/22-11-36/37/38
- SDS：
- 查看
支链氨基酸 制备方法及用途
制备方法
-
烟碱在烟草中含量平均达4%,在植物中以柠檬酸盐或苹果酸盐形式存在。工业上可利用制废料,用简单的水蒸气蒸馏提取。
合成制备方法
1.烟碱已工业化的制取方法有三种：蒸馏法、离子交换树脂法和萃取法。基本生产流程如下：
蒸馏法是将碱液加入烟叶中，然后通入过热水蒸气蒸馏，馏出水分含有游离烟碱。离子交换法是直接用清水浸泡烟叶，过滤后得到烟碱的水溶液，然后将此水溶液流经离子交换树脂柱（强酸性），烟碱即被富集在离子交换柱上，然后用碱交换即得游离烟碱的水溶液。萃取法是用石灰乳直接中和清水浸泡烟叶后得到的烟碱有机酸水溶液，过滤后的清液即为游离烟碱水溶液。用以上方法得到的烟碱溶液，先用有机溶剂萃取，再用约30%硫酸水溶液反萃该有机相，所得的硫酸烟碱水溶液经浓缩得40%硫酸烟碱。再用碱中和后，常压下蒸出多余水分，残余物减压蒸馏，可得纯度＞95%烟碱。
2.烟碱是烟草中的一种主要生物碱，已发现存在于茄科烟草属植物中，主要品种有烟草(Nicotiana tabacum)和黄花烟草 （Nicotiana rustica） 。
1 ．烟草-稀酸浸渍- 碱中和-水蒸气蒸馏-草酸处理- 碱化而制得。
2 ．烟叶-磨研 （ 或用卷烟厂副产烟末）-石灰乳碱化- 煤油过滤。
用途简介
-
烟碱是一种吡啶型生物碱,曾用作园艺上的杀虫剂。烟碱经氧化可制得烟酸,用作医药、食品和饲料添加剂。
用途
1.本品为无残留、无内吸性的触杀性杀虫剂，并有一些杀卵活性。用于水稻、果树、蔬菜可以防治稻潜蝇、稻飞虱、蚜虫、卷叶蛾、菜青虫等。也可以用于密闭空间（温室等）熏蒸。以烟碱作为先导化合物还可生产新的高效农药。
支链氨基酸 物化性质
- 外观与性状：
- 黄色液体
- 密度：
- 1.010 g/mL at 20 °C(lit.)
- 熔点：
- -80 °C
- 沸点：
- 243-248 °C
- 闪点：
- 215 °F
- 水溶解性：
- MISCIBLE
- 折射率：
- n20/D 1.5265(lit.)
- 存储条件/存储方法：
- 库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放
- 稳定性相关：
烟碱是含氮的碱性物质，很容易与盐酸反应生成烟碱盐酸盐而溶于水。在提取液中加入强碱NaOH后可使烟碱游离出来。游离烟碱在100℃左右具有一定的蒸气压（约1333Pa），因此，可用水蒸气蒸馏法分离提取。烟碱具有碱性，可以使红色石蕊试纸变蓝，也可以使酚酞试剂变红。可被KMnO4溶液氧化生成烟酸，与生物碱试剂作用产生沉淀。
- 其它信息：
- 1. 性状：纯品为无色液体，无臭
支链氨基酸 安全信息
- 包装等级：
- II
- 风险类别：
- 6.1
- 海关代码：
- 2933990090
- WGK_Germany：
- 3
德国有关水污染物质的分类清单 - 危险类别码：
- R25;R27;R51/53
- 安全说明：
- S7-S16-S36/37-S45-S61-S36-S26
- RTECS号：
- QS5250000
- 安全标志：
- :
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S61:避免排放到环境中。参考专门的说明/安全数据表。 - 危险标志：
- T+:Verytoxic;N:Dangerous for the environment;
支链氨基酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS5250000
- CHEMICAL NAME :
- Nicotine
- CAS REGISTRY NUMBER :
- 54-11-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 126
- MOLECULAR FORMULA :
- C10-H14-N2
- MOLECULAR WEIGHT :
- 162.26
- WISWESSER LINE NOTATION :
- T6NJ C- BT5NTJ A1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 882 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Rectal
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1430 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 14560 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraduodenal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3340 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 9200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 7700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 1300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 9 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 14 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 6250 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- >14 mg/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - excitement Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 4500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 4580 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 9 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - horse, donkey
- DOSE/DURATION :
- 8800 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - cattle
- DOSE/DURATION :
- 9 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - horse, donkey
- DOSE/DURATION :
- 8800 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 17800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 mg/kg/7D-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 28 mg/kg/28D-C
- TOXIC EFFECTS :
- Endocrine - other changes Immunological Including Allergic - decrease in cellular immune response
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 415 mg/kg/21D-C
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Liver - other changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 ug/kg
- SEX/DURATION :
- female 24 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 59400 ug/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 594 mg/kg
- SEX/DURATION :
- male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 22 mg/kg
- SEX/DURATION :
- lactating female 20 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - delayed effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 319 mg/kg
- SEX/DURATION :
- female 7-20 day(s) after conception lactating female 35 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 5250 ug/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 8800 ug/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - physical
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 33 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 9 mg/kg
- SEX/DURATION :
- female 14-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 32 mg/kg
- SEX/DURATION :
- female 1-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 22500 ug/kg
- SEX/DURATION :
- female 21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - postpartum Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 12 mg/kg
- SEX/DURATION :
- female 15-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - delayed effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 126 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 126 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 1-5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 125 mg/kg
- SEX/DURATION :
- female 6-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 125 mg/kg
- SEX/DURATION :
- female 6-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 125 mg/kg
- SEX/DURATION :
- female 6-12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - respiratory system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 7 mg/kg
- SEX/DURATION :
- female 8-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Implant
- DOSE :
- 19200 ug/kg
- SEX/DURATION :
- female 14-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - germ cell effects (in offspring)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- DOSE :
- 5750 ug/kg
- SEX/DURATION :
- female 7-21 day(s) after conception lactating female 8 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - biochemical and metabolic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- DOSE :
- 37 mg/kg
- SEX/DURATION :
- female 7-22 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - respiratory system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 642 mg/kg
- SEX/DURATION :
- female 21 day(s) pre-mating female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 16 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 24 mg/kg
- SEX/DURATION :
- female 7-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - skin and skin appendages
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 24 mg/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 10-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 17 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 408 mg/kg
- SEX/DURATION :
- female 1-68 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 408 mg/kg
- SEX/DURATION :
- female 1-68 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 200 ug/kg
- SEX/DURATION :
- female 16 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 13 mg/kg
- SEX/DURATION :
- female 3-19 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Effects on Newborn - stillbirth
- TYPE OF TEST :
- Dominant lethal test
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rabbit Cells - not otherwise specified
- REFERENCE :
- TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 34,309,1985 *** REVIEWS *** ACGIH TLV-TWA 0.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,181,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin JAN 1993 OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.5 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.5 mg/m3;Skin JAN 1993 OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin JAN 1993 OEL-HUNGARY:STEL 0.5 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.07 ppm (0.5 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 0.5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.14 ppm;Skin JAN 1993 OEL-THAILAND:TWA 0.5 mg/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO NICOTINE-air:10H TWA 0.5 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 50570 No. of Facilities: 83 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 161 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 50570 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 4737 (estimated) No. of Female Employees: 861 (estimated)
支链氨基酸 MSDS
| 第一部分：化学品名称 |
| 化学品中文名称： | 尼古丁；烟碱 |
| 化学品英文名称： | Nicotine |
| 中文俗名或商品名： | |
| Synonyms： | |
| CAS No.： | 54-11-5 |
| 分子式： | C10H14N2 |
| 分子量： | 162.23 |
| 第二部分：成分/组成信息 |
| 纯化学品 混合物 | |||
| 化学品名称：尼古丁；烟碱 | |||
|
| 第三部分：危险性概述 |
| 危险性类别： | 第6．1类 毒害品 |
| 侵入途径： | 吸入 食入 经皮吸收 |
| 健康危害： | 本品属神经毒，作用于植物神经、中枢神经及运动神经末梢，先兴奋，后抑制。能经消化道、呼吸道和皮肤很快吸收，引起中毒。急性中毒表现有头痛、头晕、无力、恶心、呕吐、腹痛、腹泻、心律紊乱、心前区痛、呼吸困难、大汗、流涎、瞳孔缩小等。口服胃肠道有烧灼感。重者尚有肌束震颤、进行性肌无力、血压降低、神志不清、谵妄、惊厥、高度呼吸困难。死于呼吸和心脏麻痹。对眼睛、皮肤有刺激性。 |
| 环境危害： | |
| 燃爆危险： | 本品可燃，高毒，具刺激性 |
| 第四部分：急救措施 |
| 皮肤接触： | 立即脱去污染的衣着，用肥皂水及流动清水彻底冲洗污染的皮肤、头发、指甲等。就医。 |
| 眼睛接触： | 立即提起眼睑，用流动清水冲洗10分钟或用2％碳酸氢钠溶液冲洗。 |
| 吸入： | 迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。 |
| 食入： | 误服者给饮大量温水，催吐，可用温水或1：5000高锰酸钾液彻底洗胃。就医。 |
| 第五部分：消防措施 |
| 危险特性： | 遇明火、高热可燃。与氧化剂可发生反应。受高热分解放出有毒的气体。 |
| 有害燃烧产物： | 一氧化碳、二氧化碳、氧化氮 |
| 灭火方法及灭火剂： | 雾状水、泡沫、抗溶性泡沫、干粉、二氧化碳、砂土。 |
| 消防员的个体防护： | 消防人员必须佩戴过滤式防毒面具(全面罩)或隔离式呼吸器、穿全身防火防毒服 |
| 禁止使用的灭火剂： | |
| 闪点(℃)： | 101 |
| 自燃温度(℃)： | 243 |
| 爆炸下限[%(V/V)]： | 0.7 |
| 爆炸上限[%(V/V)]： | 4.0 |
| 最小点火能(mJ)： | |
| 爆燃点： | |
| 爆速： | |
| 最大燃爆压力(MPa)： | |
| 建规火险分级： |
| 第六部分：泄漏应急处理 |
| 应急处理： | 疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴自给式呼吸器，穿化学防护服。不要直接接触泄漏物，在确保安全情况下堵漏。喷雾状水，减少蒸发。用沙土或其它不燃性吸附剂混合吸收，然后收集运至废物处理场所处置。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。 |
| 第七部分：操作处置与储存 |
| 操作注意事项： | 密闭操作，提供充分的局部排风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（全面罩），穿胶布防毒衣，戴橡胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂接触。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。 |
| 储存注意事项： | 储存于阴凉、通风的库房。远离火种、热源。应与氧化剂、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。应严格执行极毒物品“五双”管理制度。 |
| 第八部分：接触控制/个体防护 |
| 最高容许浓度： | 中国MAC：未制定标准苏联MAC：未制定标准美国TWA：OSHA 0.5mg/m3[皮]; ACGIH 0.5mg/m3[皮] |
| 监测方法： | |
| 工程控制： | 严加密闭，提供充分的局部排风。 |
| 呼吸系统防护： | 空气中浓度超标时，佩带防毒面具。紧急事态抢救或逃生时，佩带自给式呼吸器。 |
| 眼睛防护： | 一般不需特殊防护。必要时戴安全防护眼镜。 |
| 身体防护： | 穿相应的防护服。 |
| 手防护： | 戴防化学品手套。 |
| 其他防护： | 工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。单独存放被毒物污染的衣服，洗后再用。保持良好的卫生习 |
| 第九部分：理化特性 |
| 外观与性状： | 纯品为无色油状液体，有焦灼味，工业品为棕色。 |
| pH： | |
| 熔点(℃)： | <-80 |
| 沸点(℃)： | 247(分解) |
| 相对密度(水=1)： | 1．01 |
| 相对蒸气密度(空气=1)： | 5．61 |
| 饱和蒸气压(kPa)： | 0．13／61．8℃ |
| 燃烧热(kJ/mol)： | 5967.8 |
| 临界温度(℃)： | |
| 临界压力(MPa)： | |
| 辛醇/水分配系数的对数值： | |
| 闪点(℃)： | 101 |
| 引燃温度(℃)： | 243 |
| 爆炸上限%(V/V)： | 4.0 |
| 爆炸下限%(V/V)： | 0.7 |
| 分子式： | C10H14N2 |
| 分子量： | 162.23 |
| 蒸发速率： | |
| 粘性： | |
| 溶解性： | 溶于水、乙醇、氯仿、乙醚、油类。 |
| 主要用途： | 用于医药及杀虫剂等。 |
| 第十部分：稳定性和反应活性 |
| 稳定性： | 在常温常压下 稳定 |
| 禁配物： | 强氧化剂。 |
| 避免接触的条件： | |
| 聚合危害： | 不能出现 |
| 分解产物： | 一氧化碳、二氧化碳、氧化氮。 |
| 第十一部分：毒理学资料 |
| 急性毒性： | 属高毒类 LD50：50mg／kg(大鼠经口)；50mg／kg(兔经皮) LC50： |
| 急性中毒： | |
| 慢性中毒： | |
| 亚急性和慢性毒性： | |
| 刺激性： | |
| 致敏性： | |
| 致突变性： | |
| 致畸性： | |
| 致癌性： |
| 第十二部分：生态学资料 |
| 生态毒理毒性： | |
| 生物降解性： | |
| 非生物降解性： | |
| 生物富集或生物积累性： |
| 第十三部分：废弃处置 |
| 废弃物性质： | |
| 废弃处置方法： | 用焚烧法处置。焚烧炉排出的氮氧化物通过洗涤器除去。 |
| 废弃注意事项： |
| 第十四部分：运输信息 |
|
|
| 危险货物编号： | 61868 |
| UN编号： | 1654 |
| 包装标志： | |
| 包装类别： | Ⅱ |
| 包装方法： | 螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱；螺纹口玻璃瓶、塑料瓶或镀锡薄钢板桶（罐）外满底板花格箱、纤维板箱或胶合板箱。 |
| 运输注意事项： | 储存于阴凉、通风仓间内。远离火种、热源。防止阳光直射。保持容器密封。应与氧化剂、酸类、食用化工原料分开存放；不可混储混运。搬运时要轻装轻卸，防止包装及容器损坏。分装和搬运作业要注意个人防护。 |
| RETCS号： | |
| IMDG规则页码： |
| 第十五部分：法规信息 |
| 国内化学品安全管理法规： | 化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品；剧毒物品分级、分类与品名编号(GA 57-93)中，该物质属第二类 A级有机剧毒品。 |
| 国际化学品安全管理法规： |
| 第十六部分：其他信息 |
| 参考文献： | 1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989 |
| 填表时间： | 年月日 |
| 填表部门： | |
| 数据审核单位： | |
| 修改说明： | |
| 其他信息： | 1 |
| MSDS修改日期： | 年月日 |
支链氨基酸 海关数据
中国海关编码：2933990090
- 概述：
- 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
支链氨基酸 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：49.25
2、 摩尔体积（cm3/mol）：157.1
3、 等张比容(90.2K)：394.2
4、 表面张力(dyne/cm)：39.6
5、 极化率(10-24cm3)：19.52
计算化学数据
1、 疏水参数计算参考值（XlogP）：1.2
2、 氢键供体数量：0
3、 氢键受体数量：2
4、 可旋转化学键数量：1
5、 互变异构体数量：
6、 拓扑分子极性表面积（TPSA）：16.1
7、 重原子数量：12
8、 表面电荷：0
9、 复杂度：147
10、同位素原子数量：0
11、确定原子立构中心数量：1
12、不确定原子立构中心数量：0
13、确定化学键立构中心数量：0
14、不确定化学键立构中心数量：0
15、共价键单元数量：1
