四硝基甲烷,509-14-8，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

上游产品

下游产品

四硝基甲烷

中文名称：: 四硝基甲烷

中文别名：: 四硝基甲烷;
四硝甲烷

英文名称：: TETRANITROMETHANE

英文别名：: TETRANITROMETHANE;
Tetan;
RCRA waste number P112;
Methane,tetranitro;
RCRA waste no. P112;
Tetranitro-methan;
tetranitro-methane;
Tetranitrokohlenstoff

CAS No.：: 509-14-8

分子式：: CN4O8

分子量：: 196.03

精确分子量：: 195.97200

PSA：: 183.28000

MDL：: MFCD00007391

EINECS：: 208-094-7

InChI：: The Key: NYTOUQBROMCLBJ-UHFFFAOYSA-N3

风险术语：: 8-25-26-36/37/38-40

SDS：: 查看

四硝基甲烷制备方法及用途

制备方法

1.注意!产品有毒,反应要在通风橱中进行。 250毫升的锥形瓶配上具二孔的塞子,塞子的一边有一条切口作为通气孔,塞子的一孔中插入温度计,温度计的水银球应伸到近瓶底。瓶内放入31.5克(0.5摩尔)无水硝酸(d>1.53锥形瓶放在冰水中冷却到10℃以下,从插在塞子另一孔上的滴定管缓缓加入51克(0.5摩尔)乙醉,每次大约加0.5毫升。反应混合物的温度决不可超过10℃。在巳加入大约5毫升乙醉后,反应就不十分剧烈了,这时在不断摇动下每次可加入较多量的乙醉,每次加入量由1毫升逐渐增加到5毫升。在全部乙醉加入后,将塞子和温度计移去。用毛巾擦净瓶颈,用倒置的烧杯盖上,锥形瓶在原失的冰浴中自然升到窒温。混合物在室温下放置7天。把混合物倒入盛有300毫升水的500毫升园底烧瓶中,进行水蒸汽蒸馏,分出四硝基甲烷。四硝基甲烷随着最初的20毫升馏出液蒸去。把重的产品与上层水分开,先用稀碱洗,最后用水洗,然后用无水硫酸钠千燥。四硝基甲烷的产量是14-16克(57一65%)。

合成制备方法

1.注意!产品有毒，反应要在通风橱中进行。
250毫升的锥形瓶配上具二孔的塞子，塞子的一边有一条切口作为通气孔，塞子的一孔中插入温度计，温度计的水银球应伸到近瓶底。瓶内放入31.5克(0.5摩尔)无水硝酸(d>1.53锥形瓶放在冰水中冷却到10℃以下，从插在塞子另一孔上的滴定管缓缓加入51克(0.5摩尔)乙醉，每次大约加0.5毫升。反应混合物的温度决不可超过10℃。在巳加入大约5毫升乙醉后，反应就不十分剧烈了，这时在不断摇动下每次可加入较多量的乙醉，每次加入量由1毫升逐渐增加到5毫升。在全部乙醉加入后，将塞子和温度计移去。用毛巾擦净瓶颈，用倒置的烧杯盖上，锥形瓶在原失的冰浴中自然升到窒温。混合物在室温下放置7天。把混合物倒入盛有300毫升水的500毫升园底烧瓶中，进行水蒸汽蒸馏，分出四硝基甲烷。四硝基甲烷随着最初的20毫升馏出液蒸去。把重的产品与上层水分开，先用稀碱洗，最后用水洗，然后用无水硫酸钠千燥。四硝基甲烷的产量是14-16克(57一65%)。

用途简介

用作火箭燃料,分析上用于不饱和化合物的测定。

用途

用作火箭燃料，分析上用于不饱和化合物的测定。^[22]

四硝基甲烷物化性质

外观与性状：
淡黄色液体

密度：
1.637 g/mL at 25 °C(lit.)

熔点：
13-14 °C(lit.)

沸点：
126 °C(lit.)

闪点：
>230 °F

折射率：
n20/D 1.438(lit.)

存储条件/存储方法：
轻装轻放,库房通风、远离明火、高温、阳光,与氧化剂、易燃物分开存放

稳定性相关：

1.稳定性^[16] 稳定
2.禁配物^[17] 强还原剂、强碱、活性金属粉末、铜。胺类、酸、可燃物、有机物、易氧化物质。
3.避免接触的条件^[18] 受热、摩擦、震动、撞击
4.聚合危害^[19] 不聚合
5.分解产物^[20] 氮氧化物

其它信息：

1.性状：无色液体，有刺激性气味。^[1]
2.熔点（℃）：13~14^[2]
3.沸点（℃）：126^[3]
4.相对密度（水=1）：1.62（20℃）^[4]
5.相对蒸气密度（空气=1）：6.8^[5]
6.饱和蒸气压（kPa）：1.117（20℃）^[6]
7.临界温度（℃）：267.1^[7]
8.临界压力（MPa）：3.99^[8]
9.辛醇/水分配系数：-2.05^[9]
10.闪点（℃）：＜110^[10]
11.溶解性：不溶于水，可混溶于乙醇、乙醚。^[11]

四硝基甲烷安全信息

包装等级：
I

风险类别：
5.1

海关代码：
2904209090

WGK_Germany：
3
德国有关水污染物质的分类清单

危险类别码：
8-25-26-36/37/38-40

安全说明：
S17-S28-S36/37-S45

RTECS号：
PB4025000

安全标志：
S17:远离可燃物质。
S28:接触皮肤之后，立即使用大量皂液洗涤。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：
O,T+

四硝基甲烷毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PB4025000

CHEMICAL NAME :
Methane, tetranitro-

CAS REGISTRY NUMBER :
509-14-8

LAST UPDATED :
199712

DATA ITEMS CITED :
55

MOLECULAR FORMULA :
C-N4-O8

MOLECULAR WEIGHT :
196.05

WISWESSER LINE NOTATION :
WNXNWNWNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
130 mg/kg

TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
18 ppm/4H

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
12600 ug/kg

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
375 mg/kg

TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
54 ppm/4H

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
53 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
63100 ug/kg

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
100 ppm/20M

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Mammal - species unspecified

DOSE/DURATION :
500 mg/kg

TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
6350 ppb/6H/26W-I

TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
25 ppm/6H/14D-I

TOXIC EFFECTS :
Related to Chronic Data - death

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
10 ppm/6H/13W-I

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
25 ppm/6H/14D-I

TOXIC EFFECTS :
Related to Chronic Data - death

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
10 ppm/6H/13W-I

TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes Liver - changes in liver weight

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
2 ppm/6H/2Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
500 ppb/6H/2Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :
TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
2 ppm/6H/2Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :
TC - Toxic concentration (other than lowest)

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
500 ppb/6H/2Y-I

TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma
MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange

TEST SYSTEM :
Rodent - hamster Ovary

REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-386,1990 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.04 mg/m3 (0.005 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,437,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,437,1996 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,437,1996 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1 ppm (8 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,254,1971 OSHA PEL (Gen Indu):8H TWA 1 ppm (8 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 1 ppm (8 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1 ppm (8 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 1 ppm (8 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-FINLAND:TWA 1 ppm (8 mg/m3);STEL 3 ppm (24 mg/m3) JAN 1993 OEL-FRANCE:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (8 mg/m3) JAN 1993 OEL-TURKEY:TWA 1 ppm (8 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TETRANITROMETHANE-air:10H TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7237 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1445 (estimated) No. of Female Employees: 230 (estimated)

毒理学数据：

1.急性毒性^[12]
LD50：130mg/kg（大鼠经口）
LC50：18ppm（大鼠吸入，4h）
2.刺激性 暂无资料
3.亚急性与慢性毒性^[13] 在50.93mg/m³下暴露6个月存活的大鼠，见中等程度的肺炎和支气管炎，而中毒死亡的大鼠，肺炎严重。
4.致突变性^[14] 微生物致突变：鼠单晗沙门菌2μg/皿；大肠杆菌3μg/皿。姐妹染色单体交换：仓鼠卵巢1700μg/L。DNA损伤：大鼠肝70μmol/L。细胞遗传学分析：仓鼠卵巢20mg/L。
5.致癌性^[15] IARC致癌性评论：G2B，可疑人类致癌物。

生态数据：

1.生态毒性 暂无资料
2.生物降解性 暂无资料
3.非生物降解性 暂无资料

四硝基甲烷 MSDS

第一部分：化学品名称

四硝基甲烷海关数据

中国海关编码：2904209090

概述：

2904209090 其他仅含硝基或亚硝基的衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

四硝基甲烷分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值（XlogP）:0.1
2.氢键供体数量:0
3.氢键受体数量:8
4.可旋转化学键数量:0
5.互变异构体数量:无
6.拓扑分子极性表面积183
7.重原子数量:13
8.表面电荷:0
9.复杂度:209
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1

四硝基甲烷上游产品

乙炔乙酐 1,3-二硝基苯 α-硝基萘乙酸

四硝基甲烷下游产品

一甲胺液氨对硝基苯甲醚 2-硝基苯甲醚

推荐供应商

四硝基甲烷

四硝基甲烷 制备方法及用途

制备方法

合成制备方法

用途简介

用途

四硝基甲烷 物化性质

四硝基甲烷 安全信息

四硝基甲烷 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

四硝基甲烷 MSDS

四硝基甲烷 海关数据

中国海关编码：2904209090

四硝基甲烷 分子结构与计算化学数据

计算化学数据

四硝基甲烷 上游产品

四硝基甲烷 下游产品

推荐供应商

四硝基甲烷制备方法及用途

四硝基甲烷物化性质

四硝基甲烷安全信息

四硝基甲烷毒理性

四硝基甲烷海关数据

四硝基甲烷分子结构与计算化学数据

四硝基甲烷上游产品

四硝基甲烷下游产品