海关代码：

2933210000

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R36/37/38

安全说明：

S24/25

RTECS号：

MT8210000

安全标志：

S24/25:防止皮肤和眼睛接触。

危险标志：

Xi

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MT8210000

CHEMICAL NAME :

Hydantoin

CAS REGISTRY NUMBER :

461-72-3

BEILSTEIN REFERENCE NO. :

0110598

LAST UPDATED :

199701

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C3-H4-N2-O2

MOLECULAR WEIGHT :

100.09

WISWESSER LINE NOTATION :

T5MVM EVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

4140 mg/kg

SEX/DURATION :

female 1-39 week(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,1095,1981

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

14400 mg/kg

SEX/DURATION :

female 7-18 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :

TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 43,279,1991

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

12 gm/kg

SEX/DURATION :

female 11-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

9 gm/kg

SEX/DURATION :

female 8-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

12 gm/kg

SEX/DURATION :

female 8-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - eye/ear

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

6 gm/kg

SEX/DURATION :

female 8-10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 64,271,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5164 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

毒理学数据：

生殖毒性：人类女人DOSE经口TDLo：怀孕1-39天后：4140mg/kgSEX/DURATION，泌尿生殖系统发育异常；

大鼠DOSE经口TDLo：怀孕7-18天后：144000mg/kgSEX/DURATION，影响新生儿成活率指数；

小鼠DOSE经腹腔TDLo：怀孕11-13天后：12gm/kgSEX/DURATION，胎儿死亡,具体的发展异常-颅面（包括鼻子和舌头）,心血管（循环）系统；

小鼠DOSE经腹腔TDLo：怀孕8-10天后：9gm/kgSEX/DURATION，胎儿中枢神经系统生殖,肌肉骨骼系统发育异常；

小鼠DOSE经腹腔TDLo：怀孕8-10天后：12gm/kgSEX/DURATION，胎儿眼睛/耳朵发育异常；

小鼠DOSE经腹腔TDLo：怀孕8-10天后：6gm/kgSEX/DURATION，胎儿发育迟缓；

生态数据：

该物质对环境可能有危害，对水体应给予特别注意。

中国海关编码：2933210000

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

摘要/Summary：

2933210000 imidazolidine-2,4-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:6.5%。General tariff:30.0%

分子结构数据

1、   摩尔折射率：20.79

2、   摩尔体积（m³/mol）：73.7

3、   等张比容（90.2K）：187.3

4、   表面张力（dyne/cm）：41.5

5、   极化率（10^-24cm³）：8.24

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:8

6.拓扑分子极性表面积58.2

7.重原子数量:7

8.表面电荷:0

9.复杂度:120

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  乙内酰脲红外图谱(IR1)
• 
  乙内酰脲红外图谱(IR2)
• 
  乙内酰脲质谱(MS)
• 
  乙内酰脲核磁图(¹³CNMR)
• 
  乙内酰脲核磁图(¹HNMR)